NO330278B1 - Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren - Google Patents

Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren Download PDF

Info

Publication number
NO330278B1
NO330278B1 NO20031525A NO20031525A NO330278B1 NO 330278 B1 NO330278 B1 NO 330278B1 NO 20031525 A NO20031525 A NO 20031525A NO 20031525 A NO20031525 A NO 20031525A NO 330278 B1 NO330278 B1 NO 330278B1
Authority
NO
Norway
Prior art keywords
rantes
mutant
pharmaceutical composition
expression vector
dna molecule
Prior art date
Application number
NO20031525A
Other languages
English (en)
Norwegian (no)
Other versions
NO20031525L (no
NO20031525D0 (no
Inventor
Amanda Proudfoot
Timothy N C Wells
Marie Kosco-Vilbois
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of NO20031525L publication Critical patent/NO20031525L/no
Publication of NO20031525D0 publication Critical patent/NO20031525D0/no
Publication of NO330278B1 publication Critical patent/NO330278B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • C07K14/523Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20031525A 2000-10-04 2003-04-03 Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren NO330278B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00121665 2000-10-04
PCT/EP2001/011428 WO2002028419A2 (en) 2000-10-04 2001-10-03 Chemokine mutants in the treatment of multiple sclerosis

Publications (3)

Publication Number Publication Date
NO20031525L NO20031525L (no) 2003-04-03
NO20031525D0 NO20031525D0 (no) 2003-04-03
NO330278B1 true NO330278B1 (no) 2011-03-21

Family

ID=8170011

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031525A NO330278B1 (no) 2000-10-04 2003-04-03 Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren

Country Status (31)

Country Link
US (1) US7402303B2 (ko)
EP (1) EP1326628B1 (ko)
JP (1) JP3908165B2 (ko)
KR (1) KR100837898B1 (ko)
CN (1) CN1285381C (ko)
AR (1) AR030854A1 (ko)
AT (1) ATE265222T1 (ko)
AU (2) AU2002215919B2 (ko)
BG (1) BG66137B1 (ko)
BR (1) BR0114407A (ko)
CA (1) CA2423616C (ko)
CZ (1) CZ303409B6 (ko)
DE (1) DE60103078T2 (ko)
DK (1) DK1326628T3 (ko)
EA (1) EA006137B1 (ko)
EE (1) EE05174B1 (ko)
ES (1) ES2217199T3 (ko)
HK (1) HK1062811A1 (ko)
HR (1) HRP20030215B1 (ko)
HU (1) HUP0302194A3 (ko)
IL (2) IL155178A0 (ko)
MX (1) MXPA03003008A (ko)
NO (1) NO330278B1 (ko)
PL (1) PL204231B1 (ko)
PT (1) PT1326628E (ko)
RS (1) RS50738B (ko)
SI (1) SI1326628T1 (ko)
SK (1) SK287523B6 (ko)
UA (1) UA77950C2 (ko)
WO (1) WO2002028419A2 (ko)
ZA (1) ZA200302315B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005525089A (ja) 2001-12-17 2005-08-25 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ ケモカイン・アンタゴニストとして作用するケモカイン突然変異体
DE60303929T2 (de) * 2002-04-04 2006-08-10 Applied Research Systems Ars Holding N.V. Chemokin-muntanten mit verbesserter oraler bioverfügbarkeit
WO2004062688A2 (en) * 2002-12-23 2004-07-29 Applied Research Systems Ars Holding N.V. Use of cc-chemokine mutants against liver diseases
DE602004018014D1 (de) * 2003-10-22 2009-01-08 Serono Lab Cxcl8-antagonisten
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
DE60304435T2 (de) * 2004-01-19 2006-08-24 Ares Trading S.A. Verfahren zur Reinigung von in Bakterien exprimierten Proteinen
GB0412400D0 (en) * 2004-06-03 2004-07-07 Univ Newcastle Treatment of inflammatory conditions
EP1760110B1 (en) * 2005-09-03 2011-11-02 Samsung SDI Co., Ltd. Polybenzoxazine-based compound, electrolyte membrane including the same, and fuel cell employing the electrolyte membrane
GB0614755D0 (en) 2006-07-25 2006-09-06 Univ Geneve Cytokine derivatives
MX2010001307A (es) 2007-08-02 2010-07-30 Novimmune Sa Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos.
AU2011213559B2 (en) * 2010-02-08 2015-05-07 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding RANTES, and compositions comprising and methods of using the same
CA3101052A1 (en) 2018-05-28 2019-12-05 ORION Biotechnology Switzerland Sarl Methods of inhibiting cerebral inflammation
WO2022093857A1 (en) * 2020-10-26 2022-05-05 City Of Hope Oncolytic virus compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739103A (en) * 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists
EP0906954A1 (en) * 1997-09-29 1999-04-07 Applied Research Systems ARS Holding N.V. Amino-terminal truncated c-c chemokines as chemokine antagonist
DE69832216T2 (de) * 1997-12-23 2006-05-24 Fondazione Centro San Raffaele Del Monte Tabor RANTES-Mutanten und therapeutische Anwendungen davon
AU2740900A (en) * 1999-01-29 2000-08-18 Millennium Pharmaceuticals, Inc. Method of treating demyelinating inflammatory disease using ccr1 antagonists

Also Published As

Publication number Publication date
SK4062003A3 (en) 2003-08-05
HRP20030215B1 (en) 2011-09-30
HK1062811A1 (en) 2004-11-26
HUP0302194A3 (en) 2005-12-28
CN1477969A (zh) 2004-02-25
PT1326628E (pt) 2004-09-30
AU1591902A (en) 2002-04-15
MXPA03003008A (es) 2003-07-14
ES2217199T3 (es) 2004-11-01
EP1326628B1 (en) 2004-04-28
WO2002028419A2 (en) 2002-04-11
SI1326628T1 (en) 2004-10-31
PL204231B1 (pl) 2009-12-31
RS50738B (sr) 2010-08-31
CA2423616C (en) 2010-03-16
WO2002028419A3 (en) 2002-06-13
NO20031525L (no) 2003-04-03
SK287523B6 (sk) 2011-01-04
DE60103078D1 (de) 2004-06-03
EA006137B1 (ru) 2005-10-27
NO20031525D0 (no) 2003-04-03
ATE265222T1 (de) 2004-05-15
DK1326628T3 (da) 2004-08-09
PL362350A1 (en) 2004-10-18
EA200300439A1 (ru) 2003-08-28
BR0114407A (pt) 2003-07-29
UA77950C2 (en) 2007-02-15
US7402303B2 (en) 2008-07-22
HUP0302194A2 (hu) 2003-10-28
CZ2003947A3 (cs) 2003-11-12
US20040101509A1 (en) 2004-05-27
AU2002215919B2 (en) 2005-11-24
JP2004510426A (ja) 2004-04-08
IL155178A (en) 2009-07-20
JP3908165B2 (ja) 2007-04-25
AR030854A1 (es) 2003-09-03
BG107685A (bg) 2003-11-28
CA2423616A1 (en) 2002-04-11
HRP20030215A2 (en) 2005-02-28
CZ303409B6 (cs) 2012-09-05
IL155178A0 (en) 2003-11-23
DE60103078T2 (de) 2005-04-07
EE05174B1 (et) 2009-06-15
YU25703A (sh) 2006-05-25
EE200300139A (et) 2003-06-16
ZA200302315B (en) 2004-03-25
BG66137B1 (bg) 2011-07-29
EP1326628A2 (en) 2003-07-16
KR100837898B1 (ko) 2008-06-13
KR20030034238A (ko) 2003-05-01
CN1285381C (zh) 2006-11-22

Similar Documents

Publication Publication Date Title
JP4233214B2 (ja) ケモカインアンタゴニストとしてのアミノ末端切除型rantes
NO330278B1 (no) Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren
NO332309B1 (no) Antagonister av CXCRX3-bindene CXC-kjemokiner, samt fremgangsmate for fremstilling derav, DNA molekyler kodende for nevnte antagonister, ekspresjonsvektor, vertcelle, farmasoytisk preparat og anvendelse av nevnte antagonister.
AU2002215919A1 (en) Chemokine mutants in the treatment of multiple sclerosis
JP2006505243A (ja) Mcpタンパク質の新規のアンタゴニスト
AU2002358144B2 (en) Chemokine mutants acting as chemokine antagonists
AU711573B2 (en) Short forms of chemokine beta-8
EP2578603A1 (en) B cell activating factor antagonist and preparation method and use thereof
US20030138400A1 (en) Short forms of chemokine beta-8
JP2006516255A (ja) 治療薬としてのf11受容体(f11r)拮抗薬
JP3621883B2 (ja) ウイルスがコードするセマフォリンタンパク質受容体dnaおよびポリペプチド
CA2233367A1 (en) Short forms of chemokine .beta.-8
MXPA00002881A (en) Amino-terminally truncated rantes as chemokine antagonists
MXPA98002380A (en) Short shapes of bet chemiscino

Legal Events

Date Code Title Description
CREP Change of representative

Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS

MM1K Lapsed by not paying the annual fees