EA200300439A1 - Мутанты хемокинов при лечении рассеянного склероза - Google Patents
Мутанты хемокинов при лечении рассеянного склерозаInfo
- Publication number
- EA200300439A1 EA200300439A1 EA200300439A EA200300439A EA200300439A1 EA 200300439 A1 EA200300439 A1 EA 200300439A1 EA 200300439 A EA200300439 A EA 200300439A EA 200300439 A EA200300439 A EA 200300439A EA 200300439 A1 EA200300439 A1 EA 200300439A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mutants
- treatment
- multiple sclerosis
- hemokin
- chemokines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Мутанты СС-хемокинов, которые содержат, по меньшей мере, две мутации в катионном сайте петли 40-х положений аминокислот и которые по сравнению с молекулой дикого типа обладают пониженной GAG-связывающей активностью. В частности, было установлено, что такие мутантные хемокины являются эффективными при лечении рассеянного склероза и/или других демиелинизирующих заболеваний. Тройной мутант RANTES представляет соединение, показывающее наилучшие результаты.Отчет о международном поиске был опубликован 2002.06.13.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00121665 | 2000-10-04 | ||
PCT/EP2001/011428 WO2002028419A2 (en) | 2000-10-04 | 2001-10-03 | Chemokine mutants in the treatment of multiple sclerosis |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300439A1 true EA200300439A1 (ru) | 2003-08-28 |
EA006137B1 EA006137B1 (ru) | 2005-10-27 |
Family
ID=8170011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300439A EA006137B1 (ru) | 2000-10-04 | 2001-10-03 | Мутантный хемокин rantes человека и применение мутантных хемокинов для лечения рассеянного склероза |
Country Status (31)
Country | Link |
---|---|
US (1) | US7402303B2 (ru) |
EP (1) | EP1326628B1 (ru) |
JP (1) | JP3908165B2 (ru) |
KR (1) | KR100837898B1 (ru) |
CN (1) | CN1285381C (ru) |
AR (1) | AR030854A1 (ru) |
AT (1) | ATE265222T1 (ru) |
AU (2) | AU1591902A (ru) |
BG (1) | BG66137B1 (ru) |
BR (1) | BR0114407A (ru) |
CA (1) | CA2423616C (ru) |
CZ (1) | CZ303409B6 (ru) |
DE (1) | DE60103078T2 (ru) |
DK (1) | DK1326628T3 (ru) |
EA (1) | EA006137B1 (ru) |
EE (1) | EE05174B1 (ru) |
ES (1) | ES2217199T3 (ru) |
HK (1) | HK1062811A1 (ru) |
HR (1) | HRP20030215B1 (ru) |
HU (1) | HUP0302194A3 (ru) |
IL (2) | IL155178A0 (ru) |
MX (1) | MXPA03003008A (ru) |
NO (1) | NO330278B1 (ru) |
PL (1) | PL204231B1 (ru) |
PT (1) | PT1326628E (ru) |
RS (1) | RS50738B (ru) |
SI (1) | SI1326628T1 (ru) |
SK (1) | SK287523B6 (ru) |
UA (1) | UA77950C2 (ru) |
WO (1) | WO2002028419A2 (ru) |
ZA (1) | ZA200302315B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60231057D1 (de) | 2001-12-17 | 2009-03-19 | Serono Lab | Chemokine mutanten, die als chemokine antagonisten wirken |
DK1494703T3 (da) | 2002-04-04 | 2006-06-26 | Applied Research Systems | Chemokin-mutanter med forbedret oral biotilgængelighed |
WO2004062688A2 (en) * | 2002-12-23 | 2004-07-29 | Applied Research Systems Ars Holding N.V. | Use of cc-chemokine mutants against liver diseases |
CA2534828A1 (en) * | 2003-10-22 | 2005-05-06 | Applied Research Systems Ars Holding N.V. | Novel cxcl8 antagonists |
AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
SI1439191T1 (sl) * | 2004-01-19 | 2006-06-30 | Ares Trading Sa | Postopek ciscenja proteinov izrazenih v bakteriji |
GB0412400D0 (en) * | 2004-06-03 | 2004-07-07 | Univ Newcastle | Treatment of inflammatory conditions |
EP1760110B1 (en) * | 2005-09-03 | 2011-11-02 | Samsung SDI Co., Ltd. | Polybenzoxazine-based compound, electrolyte membrane including the same, and fuel cell employing the electrolyte membrane |
GB0614755D0 (en) | 2006-07-25 | 2006-09-06 | Univ Geneve | Cytokine derivatives |
DK2185719T3 (en) | 2007-08-02 | 2014-02-17 | Novimmune Sa | ANTI-RANTES ANTIBODIES AND PROCEDURES FOR USE THEREOF |
AU2011213559B2 (en) * | 2010-02-08 | 2015-05-07 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding RANTES, and compositions comprising and methods of using the same |
CN112469430A (zh) | 2018-05-28 | 2021-03-09 | 日内瓦大学 | 抑制大脑炎症的方法 |
WO2022093857A1 (en) * | 2020-10-26 | 2022-05-05 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739103A (en) | 1993-11-12 | 1998-04-14 | Dana-Farber Cancer Institute | Chemokine N-terminal deletion mutations |
WO1998006751A1 (en) * | 1996-08-16 | 1998-02-19 | Research Corporation Technologies, Inc. | Mcp-3, rantes and mip-1alpha receptor antagonists |
EP0906954A1 (en) * | 1997-09-29 | 1999-04-07 | Applied Research Systems ARS Holding N.V. | Amino-terminal truncated c-c chemokines as chemokine antagonist |
AU2415599A (en) * | 1997-12-23 | 1999-07-19 | Fondazione Centro San Raffaele Del Monte Tabor | Rantes mutants and therapeutic applications thereof |
WO2000044408A2 (en) * | 1999-01-29 | 2000-08-03 | Millennium Pharmaceuticals, Inc. | Method of treating demyelinating inflammatory disease using ccr1 antagonists |
-
2001
- 2001-03-10 UA UA2003044038A patent/UA77950C2/uk unknown
- 2001-10-03 US US10/398,457 patent/US7402303B2/en not_active Expired - Fee Related
- 2001-10-03 PT PT01986265T patent/PT1326628E/pt unknown
- 2001-10-03 IL IL15517801A patent/IL155178A0/xx unknown
- 2001-10-03 CA CA2423616A patent/CA2423616C/en not_active Expired - Fee Related
- 2001-10-03 BR BR0114407-3A patent/BR0114407A/pt not_active IP Right Cessation
- 2001-10-03 AU AU1591902A patent/AU1591902A/xx active Pending
- 2001-10-03 AU AU2002215919A patent/AU2002215919B2/en not_active Ceased
- 2001-10-03 EE EEP200300139A patent/EE05174B1/xx not_active IP Right Cessation
- 2001-10-03 RS YUP-257/03A patent/RS50738B/sr unknown
- 2001-10-03 CZ CZ20030947A patent/CZ303409B6/cs not_active IP Right Cessation
- 2001-10-03 KR KR1020037004599A patent/KR100837898B1/ko not_active IP Right Cessation
- 2001-10-03 WO PCT/EP2001/011428 patent/WO2002028419A2/en active IP Right Grant
- 2001-10-03 PL PL362350A patent/PL204231B1/pl not_active IP Right Cessation
- 2001-10-03 SI SI200130130T patent/SI1326628T1/xx unknown
- 2001-10-03 HU HU0302194A patent/HUP0302194A3/hu unknown
- 2001-10-03 CN CNB018199178A patent/CN1285381C/zh not_active Expired - Fee Related
- 2001-10-03 SK SK406-2003A patent/SK287523B6/sk not_active IP Right Cessation
- 2001-10-03 ZA ZA200302315A patent/ZA200302315B/en unknown
- 2001-10-03 DK DK01986265T patent/DK1326628T3/da active
- 2001-10-03 EA EA200300439A patent/EA006137B1/ru not_active IP Right Cessation
- 2001-10-03 ES ES01986265T patent/ES2217199T3/es not_active Expired - Lifetime
- 2001-10-03 DE DE60103078T patent/DE60103078T2/de not_active Expired - Lifetime
- 2001-10-03 AT AT01986265T patent/ATE265222T1/de active
- 2001-10-03 EP EP01986265A patent/EP1326628B1/en not_active Expired - Lifetime
- 2001-10-03 JP JP2002532243A patent/JP3908165B2/ja not_active Expired - Fee Related
- 2001-10-03 MX MXPA03003008A patent/MXPA03003008A/es active IP Right Grant
- 2001-10-04 AR ARP010104684A patent/AR030854A1/es unknown
-
2003
- 2003-03-20 HR HR20030215A patent/HRP20030215B1/xx not_active IP Right Cessation
- 2003-03-28 BG BG107685A patent/BG66137B1/bg unknown
- 2003-04-01 IL IL155178A patent/IL155178A/en not_active IP Right Cessation
- 2003-04-03 NO NO20031525A patent/NO330278B1/no not_active IP Right Cessation
-
2004
- 2004-08-02 HK HK04105657A patent/HK1062811A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |