ZA200302315B - Chemokine mutants in the treatment of multiple sclerosis. - Google Patents

Chemokine mutants in the treatment of multiple sclerosis. Download PDF

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Publication number
ZA200302315B
ZA200302315B ZA200302315A ZA200302315A ZA200302315B ZA 200302315 B ZA200302315 B ZA 200302315B ZA 200302315 A ZA200302315 A ZA 200302315A ZA 200302315 A ZA200302315 A ZA 200302315A ZA 200302315 B ZA200302315 B ZA 200302315B
Authority
ZA
South Africa
Prior art keywords
rantes
mutant
mip
chemokine
triple
Prior art date
Application number
ZA200302315A
Other languages
English (en)
Inventor
Amanda Proudfoot
Timothy Nc Wells
Marie Kosco-Vilbois
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of ZA200302315B publication Critical patent/ZA200302315B/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • C07K14/523Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200302315A 2000-10-04 2001-10-03 Chemokine mutants in the treatment of multiple sclerosis. ZA200302315B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00121665 2000-10-04

Publications (1)

Publication Number Publication Date
ZA200302315B true ZA200302315B (en) 2004-03-25

Family

ID=8170011

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200302315A ZA200302315B (en) 2000-10-04 2001-10-03 Chemokine mutants in the treatment of multiple sclerosis.

Country Status (31)

Country Link
US (1) US7402303B2 (ru)
EP (1) EP1326628B1 (ru)
JP (1) JP3908165B2 (ru)
KR (1) KR100837898B1 (ru)
CN (1) CN1285381C (ru)
AR (1) AR030854A1 (ru)
AT (1) ATE265222T1 (ru)
AU (2) AU2002215919B2 (ru)
BG (1) BG66137B1 (ru)
BR (1) BR0114407A (ru)
CA (1) CA2423616C (ru)
CZ (1) CZ303409B6 (ru)
DE (1) DE60103078T2 (ru)
DK (1) DK1326628T3 (ru)
EA (1) EA006137B1 (ru)
EE (1) EE05174B1 (ru)
ES (1) ES2217199T3 (ru)
HK (1) HK1062811A1 (ru)
HR (1) HRP20030215B1 (ru)
HU (1) HUP0302194A3 (ru)
IL (2) IL155178A0 (ru)
MX (1) MXPA03003008A (ru)
NO (1) NO330278B1 (ru)
PL (1) PL204231B1 (ru)
PT (1) PT1326628E (ru)
RS (1) RS50738B (ru)
SI (1) SI1326628T1 (ru)
SK (1) SK287523B6 (ru)
UA (1) UA77950C2 (ru)
WO (1) WO2002028419A2 (ru)
ZA (1) ZA200302315B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162600A0 (en) 2001-12-17 2005-11-20 Applied Research Systems Cc-chemokine mutants as cc-chemokine antagonists
PT1494703E (pt) * 2002-04-04 2006-05-31 Applied Research Systems Quimiocinas mutantes que apresentam uma disponibilidade biologica oral melhorada
JP2006514699A (ja) * 2002-12-23 2006-05-11 アプライド リサーチ システムズ アルス ホールディング ナムローゼ フエンノートシャップ 肝疾患に対するccケモカイン変異体の使用
AU2004283910A1 (en) * 2003-10-22 2005-05-06 Laboratoires Serono Sa Novel CXCL8 antagonists
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
EP1439191B1 (en) * 2004-01-19 2006-04-05 Ares Trading S.A. Process for the purification of bacterially expressed proteins
GB0412400D0 (en) * 2004-06-03 2004-07-07 Univ Newcastle Treatment of inflammatory conditions
EP2218748B1 (en) * 2005-09-03 2012-10-10 Samsung SDI Co., Ltd. Polybenzoxazine-based compound, electrolyte membrane including the same, and fuel cell employing the electrolyte membrane
GB0614755D0 (en) 2006-07-25 2006-09-06 Univ Geneve Cytokine derivatives
MX2010001307A (es) 2007-08-02 2010-07-30 Novimmune Sa Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos.
US9034313B2 (en) * 2010-02-08 2015-05-19 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
CA3101052A1 (en) 2018-05-28 2019-12-05 ORION Biotechnology Switzerland Sarl Methods of inhibiting cerebral inflammation
WO2022093857A1 (en) * 2020-10-26 2022-05-05 City Of Hope Oncolytic virus compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739103A (en) * 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists
EP0906954A1 (en) * 1997-09-29 1999-04-07 Applied Research Systems ARS Holding N.V. Amino-terminal truncated c-c chemokines as chemokine antagonist
JP4323094B2 (ja) 1997-12-23 2009-09-02 フォンダジオーネ セントロ サン ラファエロ デル モンテ タボール Rantes変異体およびその治療用途
JP2002535376A (ja) 1999-01-29 2002-10-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ccr1アンタゴニストを用いた脱髄性炎症性疾患の治療方法

Also Published As

Publication number Publication date
HRP20030215A2 (en) 2005-02-28
BG66137B1 (bg) 2011-07-29
ES2217199T3 (es) 2004-11-01
JP2004510426A (ja) 2004-04-08
HUP0302194A3 (en) 2005-12-28
SI1326628T1 (en) 2004-10-31
DK1326628T3 (da) 2004-08-09
IL155178A (en) 2009-07-20
KR100837898B1 (ko) 2008-06-13
KR20030034238A (ko) 2003-05-01
NO20031525L (no) 2003-04-03
CA2423616C (en) 2010-03-16
EA200300439A1 (ru) 2003-08-28
PT1326628E (pt) 2004-09-30
DE60103078T2 (de) 2005-04-07
US7402303B2 (en) 2008-07-22
WO2002028419A2 (en) 2002-04-11
BG107685A (bg) 2003-11-28
NO330278B1 (no) 2011-03-21
EP1326628B1 (en) 2004-04-28
EP1326628A2 (en) 2003-07-16
EE05174B1 (et) 2009-06-15
US20040101509A1 (en) 2004-05-27
AR030854A1 (es) 2003-09-03
JP3908165B2 (ja) 2007-04-25
DE60103078D1 (de) 2004-06-03
WO2002028419A3 (en) 2002-06-13
RS50738B (sr) 2010-08-31
EA006137B1 (ru) 2005-10-27
PL204231B1 (pl) 2009-12-31
NO20031525D0 (no) 2003-04-03
YU25703A (sh) 2006-05-25
HUP0302194A2 (hu) 2003-10-28
SK4062003A3 (en) 2003-08-05
CZ303409B6 (cs) 2012-09-05
CN1285381C (zh) 2006-11-22
IL155178A0 (en) 2003-11-23
MXPA03003008A (es) 2003-07-14
BR0114407A (pt) 2003-07-29
ATE265222T1 (de) 2004-05-15
SK287523B6 (sk) 2011-01-04
UA77950C2 (en) 2007-02-15
CN1477969A (zh) 2004-02-25
AU1591902A (en) 2002-04-15
CA2423616A1 (en) 2002-04-11
CZ2003947A3 (cs) 2003-11-12
HK1062811A1 (en) 2004-11-26
EE200300139A (et) 2003-06-16
HRP20030215B1 (en) 2011-09-30
PL362350A1 (en) 2004-10-18
AU2002215919B2 (en) 2005-11-24

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