DE60103078D1 - Chemokin mutanten zur behandlung multipler sklerose - Google Patents

Chemokin mutanten zur behandlung multipler sklerose

Info

Publication number
DE60103078D1
DE60103078D1 DE60103078T DE60103078T DE60103078D1 DE 60103078 D1 DE60103078 D1 DE 60103078D1 DE 60103078 T DE60103078 T DE 60103078T DE 60103078 T DE60103078 T DE 60103078T DE 60103078 D1 DE60103078 D1 DE 60103078D1
Authority
DE
Germany
Prior art keywords
chemokin
mutants
multiple sclerosis
treating multiple
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103078T
Other languages
English (en)
Other versions
DE60103078T2 (de
Inventor
Amanda Proudfoot
N C Wells
Marie Kosco-Vilbois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of DE60103078D1 publication Critical patent/DE60103078D1/de
Application granted granted Critical
Publication of DE60103078T2 publication Critical patent/DE60103078T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60103078T 2000-10-04 2001-10-03 Chemokin mutanten zur behandlung multipler sklerose Expired - Lifetime DE60103078T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00121665 2000-10-04
EP00121665 2000-10-04
PCT/EP2001/011428 WO2002028419A2 (en) 2000-10-04 2001-10-03 Chemokine mutants in the treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
DE60103078D1 true DE60103078D1 (de) 2004-06-03
DE60103078T2 DE60103078T2 (de) 2005-04-07

Family

ID=8170011

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103078T Expired - Lifetime DE60103078T2 (de) 2000-10-04 2001-10-03 Chemokin mutanten zur behandlung multipler sklerose

Country Status (31)

Country Link
US (1) US7402303B2 (de)
EP (1) EP1326628B1 (de)
JP (1) JP3908165B2 (de)
KR (1) KR100837898B1 (de)
CN (1) CN1285381C (de)
AR (1) AR030854A1 (de)
AT (1) ATE265222T1 (de)
AU (2) AU1591902A (de)
BG (1) BG66137B1 (de)
BR (1) BR0114407A (de)
CA (1) CA2423616C (de)
CZ (1) CZ303409B6 (de)
DE (1) DE60103078T2 (de)
DK (1) DK1326628T3 (de)
EA (1) EA006137B1 (de)
EE (1) EE05174B1 (de)
ES (1) ES2217199T3 (de)
HK (1) HK1062811A1 (de)
HR (1) HRP20030215B1 (de)
HU (1) HUP0302194A3 (de)
IL (2) IL155178A0 (de)
MX (1) MXPA03003008A (de)
NO (1) NO330278B1 (de)
PL (1) PL204231B1 (de)
PT (1) PT1326628E (de)
RS (1) RS50738B (de)
SI (1) SI1326628T1 (de)
SK (1) SK287523B6 (de)
UA (1) UA77950C2 (de)
WO (1) WO2002028419A2 (de)
ZA (1) ZA200302315B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE421974T1 (de) 2001-12-17 2009-02-15 Serono Lab Chemokine mutanten, die als chemokine antagonisten wirken
JP2005529099A (ja) 2002-04-04 2005-09-29 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 改善された経口生物学的利用能を有するケモカイン変異体
EP1575608B1 (de) * 2002-12-23 2008-05-07 Laboratoires Serono SA Verwendung von cc-chemokine ccl5/rantes mutanten zur behandlung von lebererkrankungen
CA2534828A1 (en) * 2003-10-22 2005-05-06 Applied Research Systems Ars Holding N.V. Novel cxcl8 antagonists
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
DE60304435T2 (de) * 2004-01-19 2006-08-24 Ares Trading S.A. Verfahren zur Reinigung von in Bakterien exprimierten Proteinen
GB0412400D0 (en) * 2004-06-03 2004-07-07 Univ Newcastle Treatment of inflammatory conditions
EP1760110B1 (de) * 2005-09-03 2011-11-02 Samsung SDI Co., Ltd. Polybenzoxazin Verbindung, Elektrolyt-Membran enthaltend dieser Verbindung und Elektrolyt-Membran benutzende Brenndstofzell
GB0614755D0 (en) 2006-07-25 2006-09-06 Univ Geneve Cytokine derivatives
AU2008317495B2 (en) 2007-08-02 2013-08-01 Novimmune S.A. Anti-RANTES antibodies and methods of use thereof
CN102781952B (zh) * 2010-02-08 2015-09-02 宾夕法尼亚大学托管会 编码rantes的核酸分子、包含其的组合物以及其使用方法
WO2019229615A1 (en) 2018-05-28 2019-12-05 Université De Genève Methods of inhibiting cerebral inflammation
WO2022093857A1 (en) * 2020-10-26 2022-05-05 City Of Hope Oncolytic virus compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739103A (en) 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
WO1998006751A1 (en) 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists
EP0906954A1 (de) * 1997-09-29 1999-04-07 Applied Research Systems ARS Holding N.V. Aminoterminalen verkürzten C-C Chemokine als Chemokine Antagonist
DK1040191T3 (da) * 1997-12-23 2005-12-19 San Raffaele Centro Fond RANTES-mutanter og terapeutiske anvendelser heraf
JP2002535376A (ja) * 1999-01-29 2002-10-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ｃｃｒ１アンタゴニストを用いた脱髄性炎症性疾患の治療方法

Also Published As

Publication number Publication date
CA2423616C (en) 2010-03-16
KR100837898B1 (ko) 2008-06-13
KR20030034238A (ko) 2003-05-01
CN1477969A (zh) 2004-02-25
HRP20030215B1 (en) 2011-09-30
MXPA03003008A (es) 2003-07-14
EP1326628B1 (de) 2004-04-28
JP3908165B2 (ja) 2007-04-25
AU1591902A (en) 2002-04-15
CZ303409B6 (cs) 2012-09-05
ATE265222T1 (de) 2004-05-15
HK1062811A1 (en) 2004-11-26
CN1285381C (zh) 2006-11-22
DE60103078T2 (de) 2005-04-07
UA77950C2 (en) 2007-02-15
ES2217199T3 (es) 2004-11-01
JP2004510426A (ja) 2004-04-08
DK1326628T3 (da) 2004-08-09
EP1326628A2 (de) 2003-07-16
YU25703A (sh) 2006-05-25
PL204231B1 (pl) 2009-12-31
SI1326628T1 (en) 2004-10-31
NO20031525L (no) 2003-04-03
AR030854A1 (es) 2003-09-03
HRP20030215A2 (en) 2005-02-28
PT1326628E (pt) 2004-09-30
EA200300439A1 (ru) 2003-08-28
RS50738B (sr) 2010-08-31
NO330278B1 (no) 2011-03-21
BG66137B1 (bg) 2011-07-29
SK287523B6 (sk) 2011-01-04
EE200300139A (et) 2003-06-16
EA006137B1 (ru) 2005-10-27
EE05174B1 (et) 2009-06-15
CA2423616A1 (en) 2002-04-11
SK4062003A3 (en) 2003-08-05
BR0114407A (pt) 2003-07-29
CZ2003947A3 (cs) 2003-11-12
BG107685A (bg) 2003-11-28
PL362350A1 (en) 2004-10-18
US7402303B2 (en) 2008-07-22
ZA200302315B (en) 2004-03-25
IL155178A0 (en) 2003-11-23
HUP0302194A3 (en) 2005-12-28
US20040101509A1 (en) 2004-05-27
IL155178A (en) 2009-07-20
WO2002028419A2 (en) 2002-04-11
WO2002028419A3 (en) 2002-06-13
HUP0302194A2 (hu) 2003-10-28
AU2002215919B2 (en) 2005-11-24
NO20031525D0 (no) 2003-04-03

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH