NO329143B1 - Bruseformuleringer og fremgangsmate for fremstilling derav. - Google Patents
Bruseformuleringer og fremgangsmate for fremstilling derav. Download PDFInfo
- Publication number
- NO329143B1 NO329143B1 NO20004721A NO20004721A NO329143B1 NO 329143 B1 NO329143 B1 NO 329143B1 NO 20004721 A NO20004721 A NO 20004721A NO 20004721 A NO20004721 A NO 20004721A NO 329143 B1 NO329143 B1 NO 329143B1
- Authority
- NO
- Norway
- Prior art keywords
- effervescent
- formulations according
- selegiline
- soft drink
- soda
- Prior art date
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- 229960003946 selegiline Drugs 0.000 claims abstract description 24
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims abstract description 24
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- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19814257A DE19814257A1 (de) | 1998-03-31 | 1998-03-31 | Brauseformulierungen |
| PCT/DE1999/000798 WO1999049842A1 (fr) | 1998-03-31 | 1999-03-20 | Formulations de spray |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004721D0 NO20004721D0 (no) | 2000-09-21 |
| NO20004721L NO20004721L (no) | 2000-09-21 |
| NO329143B1 true NO329143B1 (no) | 2010-08-30 |
Family
ID=7863015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004721A NO329143B1 (no) | 1998-03-31 | 2000-09-21 | Bruseformuleringer og fremgangsmate for fremstilling derav. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6242002B1 (fr) |
| EP (1) | EP1067905B1 (fr) |
| JP (1) | JP4469494B2 (fr) |
| KR (1) | KR100607395B1 (fr) |
| CN (1) | CN1138529C (fr) |
| AR (1) | AR018829A1 (fr) |
| AT (1) | ATE224703T1 (fr) |
| AU (1) | AU753194B2 (fr) |
| BG (1) | BG65043B1 (fr) |
| BR (1) | BR9909266A (fr) |
| CA (1) | CA2326502C (fr) |
| CZ (1) | CZ300705B6 (fr) |
| DE (2) | DE19814257A1 (fr) |
| DK (1) | DK1067905T3 (fr) |
| ES (1) | ES2183555T3 (fr) |
| HK (1) | HK1036010A1 (fr) |
| HU (1) | HU229793B1 (fr) |
| IL (1) | IL138605A (fr) |
| NO (1) | NO329143B1 (fr) |
| NZ (1) | NZ506989A (fr) |
| PL (1) | PL192049B1 (fr) |
| PT (1) | PT1067905E (fr) |
| RU (1) | RU2221554C2 (fr) |
| SK (1) | SK284477B6 (fr) |
| TR (1) | TR200002812T2 (fr) |
| TW (1) | TW580398B (fr) |
| UA (1) | UA66847C2 (fr) |
| WO (1) | WO1999049842A1 (fr) |
| ZA (1) | ZA200005133B (fr) |
Families Citing this family (38)
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| US6350470B1 (en) | 1998-04-29 | 2002-02-26 | Cima Labs Inc. | Effervescent drug delivery system for oral administration |
| US6200604B1 (en) * | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US20030091629A1 (en) | 1998-03-27 | 2003-05-15 | Cima Labs Inc. | Sublingual buccal effervescent |
| US20030118645A1 (en) * | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
| US6974590B2 (en) | 1998-03-27 | 2005-12-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| AU2004242477B2 (en) * | 1999-03-26 | 2007-04-19 | Cima Labs Inc. | Sublingual buccal effervescent |
| AU2007203233B2 (en) * | 1999-03-26 | 2010-02-25 | Cima Labs Inc. | Sublingual buccal effervescent |
| KR20030011797A (ko) * | 2000-03-28 | 2003-02-11 | 바이오케미 게젤샤프트 엠베하 | 맛이 차폐된 과립형 입자 |
| JP4706096B2 (ja) * | 2000-10-23 | 2011-06-22 | 大正製薬株式会社 | 不快な味を呈する塩基性薬物配合製剤 |
| US20030068356A1 (en) * | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| GB0217056D0 (en) * | 2002-07-23 | 2002-08-28 | Ass Octel | Use |
| US20040175456A1 (en) * | 2003-03-06 | 2004-09-09 | Lauren Keilbach | Tablets for feeding fish and methods of making tablets for feeding fish |
| US20040191298A1 (en) * | 2003-03-26 | 2004-09-30 | Fredrik Nicklasson | New formulations and use thereof |
| TR200300510A2 (tr) * | 2003-04-18 | 2004-11-22 | Sanovel �La� Sanay� Ve T�Caret A.�. | Dağılan alendronat mikropartikül formülasyonu |
| WO2005065319A2 (fr) | 2003-12-31 | 2005-07-21 | Cima Labs Inc. | Forme galenique de fentanyl generalement lineaire effervescente et orale et ses procedes d'administration |
| AU2004311879B2 (en) * | 2003-12-31 | 2010-08-05 | Cima Labs Inc. | Effervescent oral opiate dosage form |
| US7858121B2 (en) | 2003-12-31 | 2010-12-28 | Cima Labs, Inc. | Effervescent oral fentanyl dosage form and methods of administering fentanyl |
| US7033511B2 (en) | 2004-01-20 | 2006-04-25 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| JP2008500288A (ja) * | 2004-05-28 | 2008-01-10 | イメイジノット ピーティーワイ エルティーディー | 経口治療用化合物の供給系 |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| CN102716490A (zh) * | 2005-09-01 | 2012-10-10 | 卫材R&D管理有限公司 | 药物组合物的崩解性的改善方法 |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| AU2006317530B2 (en) * | 2005-11-28 | 2011-09-01 | Imaginot Pty Ltd | Oral therapeutic compound delivery system |
| PT2361081T (pt) * | 2008-10-14 | 2016-09-05 | Mcneil Ab | Forma de dosagem intra-oral multiporção e seu uso |
| KR101233352B1 (ko) * | 2009-04-22 | 2013-02-25 | (주)비씨월드제약 | 유전자 재조합 과립구-대식세포 집락 촉진인자를 함유하는 정제 |
| CA2765033C (fr) | 2009-06-12 | 2020-07-14 | Meritage Pharma, Inc. | Procedes de traitement de troubles gastro-intestinaux |
| AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| EP2714937B1 (fr) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de la thyroïde et du rein vis-à-vis de composés lenvatinib |
| WO2013116112A1 (fr) | 2012-02-01 | 2013-08-08 | Kraft Foods Global Brands Llc | Comprimé pour boisson hypocalorique |
| KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
| JP6411379B2 (ja) | 2013-05-14 | 2018-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する子宮内膜がん対象の応答性を予測及び評価するためのバイオマーカー |
| ES2926687T3 (es) | 2014-08-28 | 2022-10-27 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y método para su producción |
| US20180028662A1 (en) | 2015-02-25 | 2018-02-01 | Eisai R&D Management Co., Ltd. | Method for Suppressing Bitterness of Quinoline Derivative |
| CA2978226A1 (fr) | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer |
| CA2988707C (fr) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combinaison de proteine se liant au cre/inhibiteur de catenine et d'un inhibiteur de point de controle immunitaire servant au traitement du cancer |
| CN109303334B (zh) * | 2018-10-17 | 2021-04-13 | 汤臣倍健股份有限公司 | 一种口腔微泡腾片及其制备方法 |
| ES2945809T3 (es) * | 2019-10-02 | 2023-07-07 | Intas Pharmaceuticals Ltd | Composiciones farmacéuticas sólidas efervescentes prácticamente sin sodio |
| US20230242846A1 (en) * | 2020-05-28 | 2023-08-03 | Conopco, Inc., D/B/A Unilever | Tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| US4861800A (en) | 1987-08-18 | 1989-08-29 | Buyske Donald A | Method for administering the drug deprenyl so as to minimize the danger of side effects |
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| GB8807504D0 (en) | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
| GB8909793D0 (en) * | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
| US5128145A (en) | 1990-06-13 | 1992-07-07 | Alza Corporation | Dosage form for Parkinson's disease, spasticity and muscle spasms |
| HU209605B (en) | 1991-04-15 | 1994-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of wather-free transdermal preparation |
| DE59202126D1 (de) | 1991-07-01 | 1995-06-14 | Gergely Gerhard | Verfahren zur Herstellung einer pharmazeutischen Zubereitung mit wenigstens zwei verschiedenen Wirkstoffen und Verwendung einer solchen Zubereitung. |
| US5415870A (en) * | 1991-07-01 | 1995-05-16 | Gerhard Gergely | Effervescent systems using reaction doping agents |
| EP0593807A1 (fr) | 1992-10-22 | 1994-04-27 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Pansement transdermique pour l'administration de principes actifs pharmaceutiques volatiles alcalins et procédé pour sa préparation |
| MX9300110A (es) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
| AU672617B2 (en) * | 1992-06-22 | 1996-10-10 | Regents Of The University Of California, The | Glycine receptor antagonists and the use thereof |
| DE4225730C2 (de) | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
| FR2698788B1 (fr) * | 1992-12-09 | 1995-03-03 | Union Pharma Scient Appl | Composition pharmaceutique effervescente contenant de l'ibuprofène et son procédé de préparation. |
| WO1994017792A2 (fr) | 1993-01-27 | 1994-08-18 | Affymax Technologies N.V. | Compositions et procedes d'administration transdermique de medicaments |
| US5287394A (en) | 1993-03-22 | 1994-02-15 | Advanced Micro Devices, Inc. | Fast counter with uniform delay structures |
| SE9301112D0 (sv) | 1993-04-02 | 1993-04-02 | Orion-Yhtymae Oy | A new composition |
| ATE140621T1 (de) * | 1993-04-15 | 1996-08-15 | Gergely Gerhard | Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen wirkstoff, und verfahren zur herstellung |
| AU678237B2 (en) | 1993-04-20 | 1997-05-22 | Hexal Pharma Gmbh | Active substance-containing plaster |
| US5503844A (en) | 1993-05-18 | 1996-04-02 | Mli Acquisition Corp. Ii | Foam laminate transdermal patch |
| DE59407351D1 (de) | 1993-09-09 | 1999-01-07 | Gerhard Gergely | Brausegranulat und verfahren zu seiner herstellung |
| CA2176212C (fr) | 1993-11-12 | 2004-09-21 | Gerhard Gergely | Procede de production de granules |
| US5484608A (en) | 1994-03-28 | 1996-01-16 | Pharmavene, Inc. | Sustained-release drug delivery system |
| GB2290965A (en) | 1994-07-11 | 1996-01-17 | Therapicon Srl | Multiple layer capsules for drugs |
| US5603955A (en) | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
| HU223475B1 (hu) | 1994-10-24 | 2004-07-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Selegilint tartalmazó liposzoma-készítmény és eljárás ennek előállítására |
| DE29500718U1 (de) * | 1995-01-18 | 1995-04-06 | Rau, Reinhard, 37242 Bad Sooden-Allendorf | Element einer Zeltplane zum Aufbau von kohten- und jurtenähnlichen Zeltaufbauten |
| WO1997017067A1 (fr) | 1995-11-06 | 1997-05-15 | Somerset Pharmaceuticals, Inc. | Administration sublinguale et buccale de selegiline |
-
1998
- 1998-03-31 DE DE19814257A patent/DE19814257A1/de not_active Withdrawn
-
1999
- 1999-03-20 PL PL343260A patent/PL192049B1/pl unknown
- 1999-03-20 CA CA002326502A patent/CA2326502C/fr not_active Expired - Fee Related
- 1999-03-20 CN CNB998046728A patent/CN1138529C/zh not_active Expired - Fee Related
- 1999-03-20 NZ NZ506989A patent/NZ506989A/xx unknown
- 1999-03-20 DK DK99923373T patent/DK1067905T3/da active
- 1999-03-20 HU HU0101427A patent/HU229793B1/hu not_active IP Right Cessation
- 1999-03-20 DE DE59902843T patent/DE59902843D1/de not_active Expired - Lifetime
- 1999-03-20 ES ES99923373T patent/ES2183555T3/es not_active Expired - Lifetime
- 1999-03-20 RU RU2000127710/15A patent/RU2221554C2/ru not_active IP Right Cessation
- 1999-03-20 KR KR1020007010866A patent/KR100607395B1/ko not_active IP Right Cessation
- 1999-03-20 SK SK1432-2000A patent/SK284477B6/sk not_active IP Right Cessation
- 1999-03-20 AU AU40294/99A patent/AU753194B2/en not_active Ceased
- 1999-03-20 JP JP2000540808A patent/JP4469494B2/ja not_active Expired - Fee Related
- 1999-03-20 WO PCT/DE1999/000798 patent/WO1999049842A1/fr active IP Right Grant
- 1999-03-20 PT PT99923373T patent/PT1067905E/pt unknown
- 1999-03-20 AT AT99923373T patent/ATE224703T1/de active
- 1999-03-20 CZ CZ20003482A patent/CZ300705B6/cs not_active IP Right Cessation
- 1999-03-20 EP EP99923373A patent/EP1067905B1/fr not_active Expired - Lifetime
- 1999-03-20 BR BR9909266-2A patent/BR9909266A/pt not_active Application Discontinuation
- 1999-03-20 UA UA2000106081A patent/UA66847C2/uk unknown
- 1999-03-20 IL IL13860599A patent/IL138605A/xx not_active IP Right Cessation
- 1999-03-25 TW TW088104726A patent/TW580398B/zh not_active IP Right Cessation
- 1999-03-26 US US09/277,393 patent/US6242002B1/en not_active Expired - Lifetime
- 1999-03-31 TR TR2000/02812T patent/TR200002812T2/xx unknown
- 1999-03-31 AR ARP990101500A patent/AR018829A1/es not_active Application Discontinuation
-
2000
- 2000-09-21 NO NO20004721A patent/NO329143B1/no not_active IP Right Cessation
- 2000-09-26 ZA ZA200005133A patent/ZA200005133B/en unknown
- 2000-10-11 BG BG104841A patent/BG65043B1/bg unknown
-
2001
- 2001-09-20 HK HK01106643A patent/HK1036010A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |