NO328791B1 - 4-amino-6-fenylpyrrolo[2,3-D]pyrimidinderivater, fremgangsmate for fremstilling derav, anvenelse derav samt farmasoytisk preparat omfattende en slik forbindelse - Google Patents
4-amino-6-fenylpyrrolo[2,3-D]pyrimidinderivater, fremgangsmate for fremstilling derav, anvenelse derav samt farmasoytisk preparat omfattende en slik forbindelse Download PDFInfo
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- NO328791B1 NO328791B1 NO20040540A NO20040540A NO328791B1 NO 328791 B1 NO328791 B1 NO 328791B1 NO 20040540 A NO20040540 A NO 20040540A NO 20040540 A NO20040540 A NO 20040540A NO 328791 B1 NO328791 B1 NO 328791B1
- Authority
- NO
- Norway
- Prior art keywords
- pyrrolo
- amine
- pyrimidin
- phenyl
- ylmethyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 244
- 238000000034 method Methods 0.000 title claims description 51
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 title description 13
- 230000008569 process Effects 0.000 title description 3
- JSLCFLYSDVRTNX-UHFFFAOYSA-N 6-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine Chemical class C=1C2=C(N)N=CNC2=NC=1C1=CC=CC=C1 JSLCFLYSDVRTNX-UHFFFAOYSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 113
- 239000000203 mixture Substances 0.000 claims description 73
- 150000003839 salts Chemical class 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- -1 tetrahydropyran-4-ylamino Chemical group 0.000 claims description 34
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 27
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims description 26
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims description 26
- 230000005764 inhibitory process Effects 0.000 claims description 25
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 16
- 125000002757 morpholinyl group Chemical group 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
- 125000005936 piperidyl group Chemical group 0.000 claims description 16
- 125000004076 pyridyl group Chemical group 0.000 claims description 16
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- 150000001412 amines Chemical class 0.000 claims description 15
- 239000007858 starting material Substances 0.000 claims description 15
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical group 0.000 claims description 13
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 125000006239 protecting group Chemical group 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000003282 alkyl amino group Chemical group 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 8
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- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
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- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0119249.1A GB0119249D0 (en) | 2001-08-07 | 2001-08-07 | Organic compounds |
PCT/EP2002/008780 WO2003013541A1 (en) | 2001-08-07 | 2002-08-06 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20040540L NO20040540L (no) | 2004-02-05 |
NO328791B1 true NO328791B1 (no) | 2010-05-18 |
Family
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NO20040540A NO328791B1 (no) | 2001-08-07 | 2004-02-05 | 4-amino-6-fenylpyrrolo[2,3-D]pyrimidinderivater, fremgangsmate for fremstilling derav, anvenelse derav samt farmasoytisk preparat omfattende en slik forbindelse |
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US (2) | US7244729B2 (es) |
EP (1) | EP1416935B8 (es) |
JP (1) | JP4147184B2 (es) |
KR (1) | KR100597505B1 (es) |
CN (2) | CN101560214B (es) |
AR (1) | AR036213A1 (es) |
AT (1) | ATE388713T1 (es) |
AU (1) | AU2002324029B2 (es) |
BR (1) | BR0211801A (es) |
CA (1) | CA2453881C (es) |
CY (1) | CY1108129T1 (es) |
DE (1) | DE60225563T2 (es) |
DK (1) | DK1416935T3 (es) |
EC (1) | ECSP034444A (es) |
ES (1) | ES2302830T3 (es) |
GB (1) | GB0119249D0 (es) |
HK (1) | HK1065483A1 (es) |
HU (1) | HUP0401083A3 (es) |
IL (2) | IL159832A0 (es) |
MX (1) | MXPA04001191A (es) |
MY (1) | MY140398A (es) |
NO (1) | NO328791B1 (es) |
NZ (1) | NZ530824A (es) |
PE (1) | PE20030349A1 (es) |
PL (1) | PL365783A1 (es) |
PT (1) | PT1416935E (es) |
RU (1) | RU2318826C2 (es) |
SG (1) | SG156521A1 (es) |
SI (1) | SI1416935T1 (es) |
TW (1) | TWI324159B (es) |
WO (1) | WO2003013541A1 (es) |
ZA (1) | ZA200400271B (es) |
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JP2003510327A (ja) | 1999-09-30 | 2003-03-18 | ニューロジェン・コーポレーション | 特定のアルキレンジアミンで置換された複素環 |
ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
AU3540101A (en) | 2000-01-07 | 2001-07-16 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
EA200300834A1 (ru) | 2000-01-18 | 2004-02-26 | Пфайзер Продактс Инк. | Антагонисты фактора, высвобождающего кортикотропин |
DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
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