NO328509B1 - 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament - Google Patents

Info

Publication number

NO328509B1

NO328509B1 NO20004280A NO20004280A NO328509B1 NO 328509 B1 NO328509 B1 NO 328509B1 NO 20004280 A NO20004280 A NO 20004280A NO 20004280 A NO20004280 A NO 20004280A NO 328509 B1 NO328509 B1 NO 328509B1

Authority

NO

Norway

Prior art keywords

amino

cyclopentylpurine

trans

aminocyclohexyl

piperidinylamino

Prior art date

1998-02-26

Links

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• -1 6,9-disubstituted 2- [trans- (4-aminocyclohexyl) amino] purines Chemical class 0.000 title claims description 265
• 238000002360 preparation method Methods 0.000 title claims description 114
• 239000003814 drug Substances 0.000 title claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 title 1
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 789
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 528
• PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 91
• 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 54
• 229910052739 hydrogen Inorganic materials 0.000 claims description 51
• 239000001257 hydrogen Substances 0.000 claims description 51
• 150000001875 compounds Chemical class 0.000 claims description 48
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 45
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 39
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 35
• 150000002431 hydrogen Chemical class 0.000 claims description 35
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 34
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 33
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 32
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
• 201000010099 disease Diseases 0.000 claims description 26
• 125000000217 alkyl group Chemical group 0.000 claims description 22
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
• 125000003386 piperidinyl group Chemical group 0.000 claims description 21
• 238000011282 treatment Methods 0.000 claims description 17
• 125000001041 indolyl group Chemical group 0.000 claims description 16
• 125000001624 naphthyl group Chemical group 0.000 claims description 16
• 210000002569 neuron Anatomy 0.000 claims description 15
• 230000006907 apoptotic process Effects 0.000 claims description 13
• 125000001424 substituent group Chemical group 0.000 claims description 12
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
• 239000000203 mixture Substances 0.000 claims description 11
• 239000002246 antineoplastic agent Substances 0.000 claims description 10
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 10
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
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• 150000003839 salts Chemical class 0.000 claims description 9
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• 125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 8
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
• 125000006308 propyl amino group Chemical group 0.000 claims description 8
• 125000002769 thiazolinyl group Chemical group 0.000 claims description 8
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
• 230000003287 optical effect Effects 0.000 claims description 7
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 7
• 229940034982 antineoplastic agent Drugs 0.000 claims description 6
• 229940079593 drug Drugs 0.000 claims description 6
• 150000004677 hydrates Chemical class 0.000 claims description 6
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• HOXNEOGOBNKIKM-VAJGKAQFSA-N Cl.Cl.COCCOCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 Chemical compound Cl.Cl.COCCOCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 HOXNEOGOBNKIKM-VAJGKAQFSA-N 0.000 claims description 5
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