ZA991551B - 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines. - Google Patents

6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines.

Info

Publication number
ZA991551B
ZA991551B ZA9901551A ZA991551A ZA991551B ZA 991551 B ZA991551 B ZA 991551B ZA 9901551 A ZA9901551 A ZA 9901551A ZA 991551 A ZA991551 A ZA 991551A ZA 991551 B ZA991551 B ZA 991551B
Authority
ZA
South Africa
Prior art keywords
aminocyclohexyl
purines
disubstituted
trans
amino
Prior art date
Application number
ZA9901551A
Other languages
English (en)
Inventor
Jennifer A Dumont
David R Borcherding
H Randall Munson
Alan J Bitonti
Norton P Peet
Patrick W K Shum
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA991551B publication Critical patent/ZA991551B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9901551A 1998-02-26 1999-02-25 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines. ZA991551B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
US13510998P 1998-02-26 1998-02-26
US09/247,053 US6479487B1 (en) 1998-02-26 1999-02-09 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines

Publications (1)

Publication Number Publication Date
ZA991551B true ZA991551B (en) 1999-08-26

Family

ID=27363758

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9901551A ZA991551B (en) 1998-02-26 1999-02-25 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines.

Country Status (17)

Country Link
US (1) US6479487B1 (xx)
EP (1) EP1056744B1 (xx)
JP (1) JP2002504552A (xx)
CN (1) CN1143858C (xx)
AP (1) AP1054A (xx)
AU (1) AU747151B2 (xx)
BR (1) BR9909256A (xx)
CA (1) CA2320474C (xx)
EE (1) EE04815B1 (xx)
HU (1) HUP0100889A3 (xx)
IL (1) IL138043A0 (xx)
NO (1) NO328509B1 (xx)
PL (1) PL194174B1 (xx)
SK (1) SK12902000A3 (xx)
TR (1) TR200002463T2 (xx)
WO (1) WO1999043675A1 (xx)
ZA (1) ZA991551B (xx)

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FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
MXPA02010222A (es) 2000-04-18 2003-05-23 Agouron Pharma Pirazoles para inhibir proteina cinasa.
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US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
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FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
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US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
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BRPI1015135B1 (pt) 2009-06-29 2021-08-03 Incyte Holdings Corporation Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos
WO2011075643A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012087881A1 (en) 2010-12-20 2012-06-28 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CN102898356B (zh) * 2011-07-29 2015-08-26 上海医药工业研究院 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法
ES2722524T3 (es) 2011-09-02 2019-08-13 Incyte Holdings Corp Heterociclaminas como inhibidores de pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
CN103193699B (zh) * 2013-04-18 2015-04-15 安徽赛诺医药化工有限公司 一种制备普卡必利中间体的新方法
CN103508939A (zh) * 2013-06-30 2014-01-15 北京万全德众医药生物技术有限公司 一种制备普卡必利中间体1-（3-甲氧基丙基）-4-哌啶胺的方法
CN103848777B (zh) * 2014-03-18 2016-04-13 悦康药业集团有限公司 一种n-(3-甲氧基丙基)-4-氨基哌啶的合成方法
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
MD3831833T2 (ro) 2015-02-27 2023-04-30 Incyte Holdings Corp Procedee pentru prepararea unui inhibitor PI3K
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
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TWI703150B (zh) 2015-06-04 2020-09-01 美商庫拉腫瘤技術股份有限公司 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
HUE061989T2 (hu) 2016-03-16 2023-09-28 Kura Oncology Inc Szubsztituált tieno[2,3-D]pirimidin származékok mint menin-MLL inhibitorai és alkalmazási eljárások
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CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
MX2023013173A (es) 2021-05-07 2023-11-30 Kymera Therapeutics Inc Degradadores de cinasa 2 dependiente de ciclina (cdk2) y sus usos.
CN115677567A (zh) * 2022-11-15 2023-02-03 大唐环境产业集团股份有限公司 一种4-氨基-1-哌啶丙醇的合成方法

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US4232155A (en) 1979-09-13 1980-11-04 Bristol-Myers Company Purine compounds
ATE219519T1 (de) * 1989-01-23 2002-07-15 Chiron Corp Rekombinanttherapien für infektionen und hyperproliferative störungen
AU658698B2 (en) 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5516631A (en) * 1992-10-13 1996-05-14 La Jolla Cancer Research Foundation Method of inhibiting replication of hyperproliferative cells
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US5688665A (en) * 1994-01-07 1997-11-18 Fred Hutchinson Cancer Research Center Isolated nucleic acid molecules encoding the p27 KIP-1 protein
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CA2234609C (en) 1995-11-01 2006-11-28 Novartis Ag 2-amino-6-anilino-purine derivatives and processes for their preparation
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CA2297967A1 (en) 1997-08-07 1999-02-18 The Regents Of The University Of California Purine inhibitor of protein kinases, g proteins and polymerases
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FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Also Published As

Publication number Publication date
EE04815B1 (et) 2007-04-16
IL138043A0 (en) 2001-10-31
NO20004280D0 (no) 2000-08-25
SK12902000A3 (sk) 2001-04-09
EP1056744A1 (en) 2000-12-06
CA2320474C (en) 2005-05-10
EP1056744B1 (en) 2003-10-22
US6479487B1 (en) 2002-11-12
AU747151B2 (en) 2002-05-09
NO20004280L (no) 2000-10-25
PL194174B1 (pl) 2007-05-31
WO1999043675A1 (en) 1999-09-02
CN1292789A (zh) 2001-04-25
AU2770999A (en) 1999-09-15
EE200000489A (et) 2002-04-15
TR200002463T2 (tr) 2000-12-21
AP1054A (en) 2002-04-01
NO328509B1 (no) 2010-03-08
CN1143858C (zh) 2004-03-31
JP2002504552A (ja) 2002-02-12
BR9909256A (pt) 2000-11-28
HUP0100889A2 (hu) 2002-01-28
CA2320474A1 (en) 1999-09-02
PL342604A1 (en) 2001-06-18
HUP0100889A3 (en) 2003-07-28
AP2000001922A0 (en) 2000-09-30

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