CN103193699B - 一种制备普卡必利中间体的新方法 - Google Patents
一种制备普卡必利中间体的新方法 Download PDFInfo
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- CN103193699B CN103193699B CN201310135118.0A CN201310135118A CN103193699B CN 103193699 B CN103193699 B CN 103193699B CN 201310135118 A CN201310135118 A CN 201310135118A CN 103193699 B CN103193699 B CN 103193699B
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- 0 C*CCCN1CCC(*)CC1 Chemical compound C*CCCN1CCC(*)CC1 0.000 description 1
- TYTCCHDSBUCLPV-UHFFFAOYSA-N CC1(CC=CCC1)O Chemical compound CC1(CC=CCC1)O TYTCCHDSBUCLPV-UHFFFAOYSA-N 0.000 description 1
- VRJHQPZVIGNGMX-UHFFFAOYSA-N O=C1CCNCC1 Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 description 1
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CN201310135118.0A CN103193699B (zh) | 2013-04-18 | 2013-04-18 | 一种制备普卡必利中间体的新方法 |
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CN201310135118.0A CN103193699B (zh) | 2013-04-18 | 2013-04-18 | 一种制备普卡必利中间体的新方法 |
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CN103193699A CN103193699A (zh) | 2013-07-10 |
CN103193699B true CN103193699B (zh) | 2015-04-15 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103848777B (zh) * | 2014-03-18 | 2016-04-13 | 悦康药业集团有限公司 | 一种n-(3-甲氧基丙基)-4-氨基哌啶的合成方法 |
CN106146386A (zh) * | 2015-04-21 | 2016-11-23 | 江苏威凯尔医药科技有限公司 | 一种制备普卡必利中间体的新工艺 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999043675A1 (en) * | 1998-02-26 | 1999-09-02 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
CN102898356A (zh) * | 2011-07-29 | 2013-01-30 | 上海医药工业研究院 | 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999043675A1 (en) * | 1998-02-26 | 1999-09-02 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
CN102898356A (zh) * | 2011-07-29 | 2013-01-30 | 上海医药工业研究院 | 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法 |
Non-Patent Citations (3)
Title |
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Preparation of aliphatic amines by the Leuckart Reaction;Lin Yang等;《AIChE Annual Meeting, Conference Proceedings, Philadelphia, PA, United States, Nov. 16-21, 2008》;20081231;第2页第3-13、15-21行,第3页第27行,第4页表 * |
Studies on the mechanism of the Leuckart reaction;Elliot R. Alexander等;《Journal of the American Chemical Society》;19480331;第70卷(第3期);1187-1189 * |
琥珀酸普卡必利的合成;原志友等;《中国医药工业杂志》;20120110;第43卷(第1期);第5-8页 * |
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Address after: 238251 Anhui Ma'anshan county and Wujiang fine chemical base Patentee after: FARMASINO PHARMACEUTICAL (ANHUI) CO.,LTD. Patentee after: FARMASINO PHARMACEUTICALS (JIANGSU) CO.,LTD. Address before: 238251 Anhui Ma'anshan county and Wujiang fine chemical base Patentee before: FarmaSino Pharmaceuticals (Anhui) Co.,Ltd. Patentee before: FARMASINO PHARMACEUTICALS (JIANGSU) CO.,LTD. |
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Address after: 238251 Wujiang fine chemical base, he County, Ma'anshan City, Anhui Province Patentee after: FARMASINO PHARMACEUTICAL (ANHUI) Co.,Ltd. Patentee after: Jiangsu Kaiyuan Pharmaceutical Co.,Ltd. Address before: 238251 Wujiang fine chemical base, he County, Ma'anshan City, Anhui Province Patentee before: FARMASINO PHARMACEUTICAL (ANHUI) Co.,Ltd. Patentee before: FARMASINO PHARMACEUTICALS (JIANGSU) Co.,Ltd. |
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Effective date of registration: 20210926 Address after: 210033 9th floor, F6 building, No.9, Weidi Road, Qixia District, Nanjing City, Jiangsu Province Patentee after: SKYRUN PHARMA Co.,Ltd. Address before: 238251 Wujiang fine chemical base, he County, Ma'anshan City, Anhui Province Patentee before: FARMASINO PHARMACEUTICAL (ANHUI) Co.,Ltd. Patentee before: Jiangsu Kaiyuan Pharmaceutical Co.,Ltd. |