IL138043A0 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines

Info

Publication number
IL138043A0
IL138043A0 IL13804399A IL13804399A IL138043A0 IL 138043 A0 IL138043 A0 IL 138043A0 IL 13804399 A IL13804399 A IL 13804399A IL 13804399 A IL13804399 A IL 13804399A IL 138043 A0 IL138043 A0 IL 138043A0
Authority
IL
Israel
Prior art keywords
aminocyclohexyl
purines
disubstituted
trans
amino
Prior art date
Application number
IL13804399A
Other languages
English (en)
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of IL138043A0 publication Critical patent/IL138043A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13804399A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines IL138043A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
US13510998P 1998-02-26 1998-02-26
US09/247,053 US6479487B1 (en) 1998-02-26 1999-02-09 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
PCT/US1999/003450 WO1999043675A1 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
IL138043A0 true IL138043A0 (en) 2001-10-31

Family

ID=27363758

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13804399A IL138043A0 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines

Country Status (17)

Country Link
US (1) US6479487B1 (pl)
EP (1) EP1056744B1 (pl)
JP (1) JP2002504552A (pl)
CN (1) CN1143858C (pl)
AP (1) AP1054A (pl)
AU (1) AU747151B2 (pl)
BR (1) BR9909256A (pl)
CA (1) CA2320474C (pl)
EE (1) EE04815B1 (pl)
HU (1) HUP0100889A3 (pl)
IL (1) IL138043A0 (pl)
NO (1) NO328509B1 (pl)
PL (1) PL194174B1 (pl)
SK (1) SK12902000A3 (pl)
TR (1) TR200002463T2 (pl)
WO (1) WO1999043675A1 (pl)
ZA (1) ZA991551B (pl)

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US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
ATE322494T1 (de) * 2000-01-07 2006-04-15 Universitaire Instelling Antwe Purin derivate, ihre herstellung und verwendung
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
MXPA02010222A (es) 2000-04-18 2003-05-23 Agouron Pharma Pirazoles para inhibir proteina cinasa.
EP1307462A2 (en) 2000-08-09 2003-05-07 Agouron Pharmaceuticals, Inc. Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases
WO2002016326A1 (en) 2000-08-18 2002-02-28 Agouron Pharmaceuticals, Inc. Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
DK1377579T3 (da) * 2000-10-31 2009-08-31 Aventis Pharma Inc Acyl- og sulfonylderivater af 6,9-disubstitueret-2(trans-1,4-diaminocyklohexyl)puriner og deres anvendelse som antiproliferative midler
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
ES2311755T3 (es) * 2002-12-13 2009-02-16 Smithkline Beecham Corporation Compuestos de ciclohexilo como antagonistas de ccrs.
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
KR100677396B1 (ko) * 2004-11-20 2007-02-02 엘지전자 주식회사 음성인식장치의 음성구간 검출방법
BRPI1015135B1 (pt) 2009-06-29 2021-08-03 Incyte Holdings Corporation Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos
WO2011075643A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012087881A1 (en) 2010-12-20 2012-06-28 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CN102898356B (zh) * 2011-07-29 2015-08-26 上海医药工业研究院 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法
ES2722524T3 (es) 2011-09-02 2019-08-13 Incyte Holdings Corp Heterociclaminas como inhibidores de pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
CN103193699B (zh) * 2013-04-18 2015-04-15 安徽赛诺医药化工有限公司 一种制备普卡必利中间体的新方法
CN103508939A (zh) * 2013-06-30 2014-01-15 北京万全德众医药生物技术有限公司 一种制备普卡必利中间体1-（3-甲氧基丙基）-4-哌啶胺的方法
CN103848777B (zh) * 2014-03-18 2016-04-13 悦康药业集团有限公司 一种n-(3-甲氧基丙基)-4-氨基哌啶的合成方法
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
MD3831833T2 (ro) 2015-02-27 2023-04-30 Incyte Holdings Corp Procedee pentru prepararea unui inhibitor PI3K
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
TWI703150B (zh) 2015-06-04 2020-09-01 美商庫拉腫瘤技術股份有限公司 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
HUE061989T2 (hu) 2016-03-16 2023-09-28 Kura Oncology Inc Szubsztituált tieno[2,3-D]pirimidin származékok mint menin-MLL inhibitorai és alkalmazási eljárások
MX2018011092A (es) 2016-03-16 2018-11-22 Kura Oncology Inc Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso.
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
MX2023013173A (es) 2021-05-07 2023-11-30 Kymera Therapeutics Inc Degradadores de cinasa 2 dependiente de ciclina (cdk2) y sus usos.
CN115677567A (zh) * 2022-11-15 2023-02-03 大唐环境产业集团股份有限公司 一种4-氨基-1-哌啶丙醇的合成方法

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US4232155A (en) 1979-09-13 1980-11-04 Bristol-Myers Company Purine compounds
ATE219519T1 (de) * 1989-01-23 2002-07-15 Chiron Corp Rekombinanttherapien für infektionen und hyperproliferative störungen
AU658698B2 (en) 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5516631A (en) * 1992-10-13 1996-05-14 La Jolla Cancer Research Foundation Method of inhibiting replication of hyperproliferative cells
GB9301000D0 (en) 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
US5688665A (en) * 1994-01-07 1997-11-18 Fred Hutchinson Cancer Research Center Isolated nucleic acid molecules encoding the p27 KIP-1 protein
GB9414208D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
CA2234609C (en) 1995-11-01 2006-11-28 Novartis Ag 2-amino-6-anilino-purine derivatives and processes for their preparation
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
CA2297967A1 (en) 1997-08-07 1999-02-18 The Regents Of The University Of California Purine inhibitor of protein kinases, g proteins and polymerases
MXPA01007851A (es) 1999-02-01 2003-06-04 Cv Therapeutics Inc Inhibidores purina de cinasa 2 e 1kb-alfa dependientes del ciclin.
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Also Published As

Publication number Publication date
EE04815B1 (et) 2007-04-16
NO20004280D0 (no) 2000-08-25
SK12902000A3 (sk) 2001-04-09
EP1056744A1 (en) 2000-12-06
CA2320474C (en) 2005-05-10
EP1056744B1 (en) 2003-10-22
ZA991551B (en) 1999-08-26
US6479487B1 (en) 2002-11-12
AU747151B2 (en) 2002-05-09
NO20004280L (no) 2000-10-25
PL194174B1 (pl) 2007-05-31
WO1999043675A1 (en) 1999-09-02
CN1292789A (zh) 2001-04-25
AU2770999A (en) 1999-09-15
EE200000489A (et) 2002-04-15
TR200002463T2 (tr) 2000-12-21
AP1054A (en) 2002-04-01
NO328509B1 (no) 2010-03-08
CN1143858C (zh) 2004-03-31
JP2002504552A (ja) 2002-02-12
BR9909256A (pt) 2000-11-28
HUP0100889A2 (hu) 2002-01-28
CA2320474A1 (en) 1999-09-02
PL342604A1 (en) 2001-06-18
HUP0100889A3 (en) 2003-07-28
AP2000001922A0 (en) 2000-09-30

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MM9K Patent not in force due to non-payment of renewal fees