NO328390B1 - Farmasoytisk sammensetning, anvendelse av antioksidant for a stabilisere nevnte sammensetning, samt transdermal innretning omfattende nevnte sammensetning - Google Patents
Farmasoytisk sammensetning, anvendelse av antioksidant for a stabilisere nevnte sammensetning, samt transdermal innretning omfattende nevnte sammensetning Download PDFInfo
- Publication number
- NO328390B1 NO328390B1 NO20003472A NO20003472A NO328390B1 NO 328390 B1 NO328390 B1 NO 328390B1 NO 20003472 A NO20003472 A NO 20003472A NO 20003472 A NO20003472 A NO 20003472A NO 328390 B1 NO328390 B1 NO 328390B1
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- Norway
- Prior art keywords
- pharmaceutical composition
- weight
- antioxidant
- layer
- compound
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 63
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 16
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 16
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- 235000006708 antioxidants Nutrition 0.000 claims abstract description 15
- 239000002253 acid Substances 0.000 claims abstract description 9
- 239000012458 free base Substances 0.000 claims abstract description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 8
- 150000003839 salts Chemical group 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims description 41
- 229940126062 Compound A Drugs 0.000 claims description 40
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- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
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- 208000024827 Alzheimer disease Diseases 0.000 description 1
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 1
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- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
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- 125000004432 carbon atom Chemical group C* 0.000 description 1
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- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- YMBNBZFZTXCWDV-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2,3-triol Chemical compound OCCO.OCC(O)CO YMBNBZFZTXCWDV-UHFFFAOYSA-N 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940074047 glyceryl cocoate Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940100242 glycol stearate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 239000012528 membrane Substances 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800526.7A GB9800526D0 (en) | 1998-01-12 | 1998-01-12 | Organic compounds |
| PCT/EP1999/000078 WO1999034782A1 (en) | 1998-01-12 | 1999-01-08 | Tts containing an antioxidant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003472D0 NO20003472D0 (no) | 2000-07-05 |
| NO20003472L NO20003472L (no) | 2000-08-07 |
| NO328390B1 true NO328390B1 (no) | 2010-02-08 |
Family
ID=10825116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003472A NO328390B1 (no) | 1998-01-12 | 2000-07-05 | Farmasoytisk sammensetning, anvendelse av antioksidant for a stabilisere nevnte sammensetning, samt transdermal innretning omfattende nevnte sammensetning |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6335031B1 (cs) |
| EP (1) | EP1047409B1 (cs) |
| KR (1) | KR100569051B1 (cs) |
| CN (1) | CN1129427C (cs) |
| AT (1) | ATE223711T1 (cs) |
| AU (1) | AU745661B2 (cs) |
| BR (1) | BR9906920A (cs) |
| CA (1) | CA2315784C (cs) |
| CZ (1) | CZ300598B6 (cs) |
| DE (1) | DE69902875T2 (cs) |
| DK (1) | DK1047409T3 (cs) |
| ES (1) | ES2184408T3 (cs) |
| GB (1) | GB9800526D0 (cs) |
| HU (1) | HU227159B1 (cs) |
| ID (1) | ID27503A (cs) |
| IL (1) | IL137100A (cs) |
| MX (1) | MXPA00006438A (cs) |
| NO (1) | NO328390B1 (cs) |
| NZ (1) | NZ505650A (cs) |
| PL (1) | PL201328B1 (cs) |
| PT (1) | PT1047409E (cs) |
| RU (1) | RU2219926C2 (cs) |
| SK (1) | SK284622B6 (cs) |
| TR (2) | TR200001688T2 (cs) |
| WO (1) | WO1999034782A1 (cs) |
Families Citing this family (34)
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| ATE286725T1 (de) * | 1998-10-01 | 2005-01-15 | Novartis Pharma Gmbh | Neue oral anzuwendende arzneizubereitungen für rivastigmine mit kontrollierter wirkstoffabgabe |
| FR2793689B1 (fr) * | 1999-05-19 | 2001-08-24 | Pf Medicament | Dispositif transdermique pour l'administration de testosterone ou d'un de ses derives |
| AU779523B2 (en) * | 1999-11-29 | 2005-01-27 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic systems with improved stability and a method for the production thereof |
| DE10107663B4 (de) * | 2001-02-19 | 2004-09-09 | Lts Lohmann Therapie-Systeme Ag | Testosteronhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
| ITMI20020798A1 (it) * | 2002-04-15 | 2003-10-15 | F T Holding S A | Cerotti transdermici a matrice adesiva siliconica stabilizzati con copolimeri metacrilici |
| FR2881653A1 (fr) * | 2005-02-04 | 2006-08-11 | Frederic Khodja | Dispositif permettant l'administration en continu d'une dose physiologique controlee d'au moins un mineral ou une vitamine |
| TWI389709B (zh) * | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| WO2009022345A1 (en) * | 2007-08-14 | 2009-02-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Phenyl carbamates for the treatment of multiple sclerosis |
| GEP20146122B (en) * | 2008-07-28 | 2014-07-25 | Takeda Pharmaceuticals Co | Pharmaceutical composition |
| US20100087768A1 (en) * | 2008-10-02 | 2010-04-08 | Forlano Paula | Transdermal drug delivery system for liquid active ingredient |
| AU2010335309B2 (en) | 2009-12-22 | 2015-08-20 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
| US10076502B2 (en) | 2009-12-22 | 2018-09-18 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
| ES2363395B1 (es) * | 2010-01-20 | 2012-02-23 | Farmalider, S.A. | Composición farmacéutica l�?quida de rivastigmina o de una de sus sales de adición de �?cido para la administración por v�?a oral. |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| DE102010026903A1 (de) | 2010-07-12 | 2012-01-12 | Amw Gmbh | Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff |
| KR101892764B1 (ko) * | 2010-07-21 | 2018-08-28 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 경피 접착제 조성물, 디바이스, 및 방법 |
| DK2468274T3 (en) * | 2010-12-14 | 2015-08-31 | Acino Ag | Transdermal therapeutic system for administration of an active substance |
| KR101788802B1 (ko) * | 2010-12-24 | 2017-10-20 | 주식회사 삼양바이오팜 | 리바스티그민을 함유하는 경피흡수제제 |
| KR20120126898A (ko) * | 2011-05-13 | 2012-11-21 | 에스케이케미칼주식회사 | 리바스티그민 또는 이의 염을 함유하는 경피 투여 조성물 |
| BR112013029945A2 (pt) | 2011-05-20 | 2017-01-31 | Sk Chemicals Co Ltd | emplastro contendo rivastigmina |
| KR20120130073A (ko) * | 2011-05-20 | 2012-11-28 | 에스케이케미칼주식회사 | 리바스티그민 함유 패취 |
| EP2594261A1 (en) | 2011-11-18 | 2013-05-22 | Labtec GmbH | Composition for transdermal administration of rivastigmine |
| DE102012000369A1 (de) | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| WO2013142339A1 (en) | 2012-03-23 | 2013-09-26 | Novartis Ag | Transdermal therapeutic system and method |
| WO2013187451A1 (ja) | 2012-06-12 | 2013-12-19 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| WO2014034939A1 (ja) * | 2012-09-03 | 2014-03-06 | ニプロパッチ株式会社 | 貼付剤 |
| KR20140038237A (ko) * | 2012-09-20 | 2014-03-28 | 에스케이케미칼주식회사 | 리바스티그민의 안정성이 개선된 의약품 |
| WO2014051128A1 (ja) | 2012-09-28 | 2014-04-03 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| WO2014111790A2 (en) | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| EP3129012A4 (en) * | 2014-04-08 | 2017-10-11 | Teikoku Pharma USA, Inc. | Rivastigmine transdermal compositions and methods of using the same |
| WO2015174502A1 (ja) | 2014-05-15 | 2015-11-19 | ニチバン株式会社 | リバスチグミンを含有する貼付剤のための包装体 |
| KR102823139B1 (ko) | 2018-08-31 | 2025-06-19 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| KR102710072B1 (ko) | 2018-08-31 | 2024-09-24 | 에스케이케미칼 주식회사 | 장기 투여용 리바스티그민 패취 |
| CN115087445A (zh) * | 2020-02-19 | 2022-09-20 | 住友制药株式会社 | 经皮吸收制剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL195004C (nl) * | 1987-03-04 | 2003-11-04 | Novartis Ag | Fenylcarbamaat bevattend farmaceutisch preparaat. |
| GB9213322D0 (en) * | 1992-06-23 | 1992-08-05 | Efamol Holdings | Antioxidant compositions |
| WO1998030243A1 (en) * | 1997-01-08 | 1998-07-16 | Warner-Lambert Company | Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease |
| WO1998031356A1 (en) * | 1997-01-17 | 1998-07-23 | Takeda Chemical Industries, Ltd. | Idebenone containing combination agent for treating alzheimer's disease |
-
1998
- 1998-01-12 GB GBGB9800526.7A patent/GB9800526D0/en not_active Ceased
-
1999
- 1999-01-08 ES ES99902525T patent/ES2184408T3/es not_active Expired - Lifetime
- 1999-01-08 WO PCT/EP1999/000078 patent/WO1999034782A1/en not_active Ceased
- 1999-01-08 CN CN99802092A patent/CN1129427C/zh not_active Expired - Lifetime
- 1999-01-08 BR BR9906920-2A patent/BR9906920A/pt not_active Application Discontinuation
- 1999-01-08 AU AU22785/99A patent/AU745661B2/en not_active Expired
- 1999-01-08 PT PT99902525T patent/PT1047409E/pt unknown
- 1999-01-08 MX MXPA00006438A patent/MXPA00006438A/es active IP Right Grant
- 1999-01-08 IL IL13710099A patent/IL137100A/en not_active IP Right Cessation
- 1999-01-08 PL PL341347A patent/PL201328B1/pl unknown
- 1999-01-08 CZ CZ20002557A patent/CZ300598B6/cs not_active IP Right Cessation
- 1999-01-08 SK SK1053-2000A patent/SK284622B6/sk not_active IP Right Cessation
- 1999-01-08 NZ NZ505650A patent/NZ505650A/xx not_active IP Right Cessation
- 1999-01-08 ID IDW20001301A patent/ID27503A/id unknown
- 1999-01-08 KR KR1020007006433A patent/KR100569051B1/ko not_active Ceased
- 1999-01-08 DE DE69902875T patent/DE69902875T2/de not_active Expired - Lifetime
- 1999-01-08 EP EP99902525A patent/EP1047409B1/en not_active Expired - Lifetime
- 1999-01-08 DK DK99902525T patent/DK1047409T3/da active
- 1999-01-08 CA CA002315784A patent/CA2315784C/en not_active Expired - Lifetime
- 1999-01-08 RU RU2000120951/15A patent/RU2219926C2/ru active
- 1999-01-08 TR TR2000/01688T patent/TR200001688T2/xx unknown
- 1999-01-08 TR TR2001/01021T patent/TR200101021T2/xx unknown
- 1999-01-08 AT AT99902525T patent/ATE223711T1/de active
- 1999-01-08 HU HU0004300A patent/HU227159B1/hu unknown
- 1999-04-14 US US09/291,498 patent/US6335031B1/en not_active Expired - Lifetime
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2000
- 2000-07-05 NO NO20003472A patent/NO328390B1/no not_active IP Right Cessation
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