NO328147B1 - Semi-syntetiske ecteinascidiner - Google Patents

Semi-syntetiske ecteinascidiner Download PDF

Info

Publication number
NO328147B1
NO328147B1 NO20004978A NO20004978A NO328147B1 NO 328147 B1 NO328147 B1 NO 328147B1 NO 20004978 A NO20004978 A NO 20004978A NO 20004978 A NO20004978 A NO 20004978A NO 328147 B1 NO328147 B1 NO 328147B1
Authority
NO
Norway
Prior art keywords
semi
compound
mmol
iso
equiv
Prior art date
Application number
NO20004978A
Other languages
English (en)
Norwegian (no)
Other versions
NO20004978D0 (no
NO20004978L (no
Inventor
Kenneth Lloyd Rinehart
Jose J Morales
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of NO20004978D0 publication Critical patent/NO20004978D0/no
Publication of NO20004978L publication Critical patent/NO20004978L/no
Publication of NO328147B1 publication Critical patent/NO328147B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
NO20004978A 1998-04-06 2000-10-03 Semi-syntetiske ecteinascidiner NO328147B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (3)

Publication Number Publication Date
NO20004978D0 NO20004978D0 (no) 2000-10-03
NO20004978L NO20004978L (no) 2000-12-05
NO328147B1 true NO328147B1 (no) 2009-12-21

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004978A NO328147B1 (no) 1998-04-06 2000-10-03 Semi-syntetiske ecteinascidiner

Country Status (27)

Country Link
US (1) US6124293A (cs)
EP (2) EP1067933B1 (cs)
JP (1) JP4443043B2 (cs)
KR (1) KR100603219B1 (cs)
CN (1) CN1157189C (cs)
AT (1) ATE370148T1 (cs)
AU (1) AU758100B2 (cs)
BG (1) BG65088B1 (cs)
BR (1) BR9909488B1 (cs)
CA (1) CA2327468C (cs)
CY (1) CY1106988T1 (cs)
CZ (1) CZ301083B6 (cs)
DE (1) DE69936845T2 (cs)
DK (1) DK1067933T3 (cs)
ES (1) ES2292237T3 (cs)
HU (1) HUP0104273A3 (cs)
IL (2) IL138856A0 (cs)
MX (1) MXPA00009840A (cs)
NO (1) NO328147B1 (cs)
NZ (1) NZ507350A (cs)
PL (1) PL196809B1 (cs)
PT (1) PT1067933E (cs)
RU (1) RU2217432C2 (cs)
SK (1) SK285669B6 (cs)
TR (1) TR200002921T2 (cs)
UA (1) UA59439C2 (cs)
WO (1) WO1999051238A1 (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CN100339375C (zh) * 1998-05-11 2007-09-26 法马马有限公司 海鞘素743的代谢物
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
WO2001053299A1 (en) * 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
AU3956502A (en) 2000-11-03 2002-05-27 Harvard College Saframycins, analogues and uses thereof
IL155781A0 (en) * 2000-11-06 2003-12-23 Pharma Mar Sa Effective antitumor treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DK1689404T3 (da) 2003-11-13 2009-01-26 Pharma Mar Sau Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
WO2005049030A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CA2583464A1 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
MX2007004744A (es) * 2004-10-26 2007-10-23 Pharma Mar Sa Doxorubicina lipos??mica pegilada en combinacion con ecteinascidina 743.
EP1658848B1 (en) 2004-10-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
ES2719091T3 (es) 2010-11-12 2019-07-08 Pharma Mar Sa Terapia de combinación con un inhibidor mitótico
EP3412293A4 (en) * 2016-02-04 2019-10-16 Jiangsu Hengrui Medicine Co., Ltd. INJECTABLE PHARMACEUTICAL COMPOSITION WITH TRABECTEDIN FOR EXTERNAL GASTROINTESTINAL USE AND METHOD FOR THE PRODUCTION THEREOF
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
KR20220119618A (ko) 2019-11-21 2022-08-30 파르마 마르, 에스.에이. 루비넥테딘 제형으로 소세포폐암을 치료하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
TW221441B (cs) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
RU2217432C2 (ru) 2003-11-27
EP1067933B1 (en) 2007-08-15
PL343439A1 (en) 2001-08-13
EP1876180A3 (en) 2009-12-16
CZ301083B6 (cs) 2009-11-04
NZ507350A (en) 2003-03-28
DK1067933T3 (da) 2007-12-27
TR200002921T2 (tr) 2001-02-21
WO1999051238A9 (en) 2000-01-27
BG65088B1 (bg) 2007-02-28
KR20010074474A (ko) 2001-08-04
UA59439C2 (uk) 2003-09-15
CA2327468A1 (en) 1999-10-14
AU758100B2 (en) 2003-03-13
IL138856A0 (en) 2001-10-31
EP1067933A1 (en) 2001-01-17
HK1033651A1 (en) 2001-09-14
BR9909488A (pt) 2000-12-26
EP1876180A2 (en) 2008-01-09
CA2327468C (en) 2008-05-06
DE69936845D1 (de) 2007-09-27
RU2000128058A (ru) 2004-02-20
CN1304309A (zh) 2001-07-18
BR9909488B1 (pt) 2011-02-08
JP4443043B2 (ja) 2010-03-31
IL138856A (en) 2007-07-24
ATE370148T1 (de) 2007-09-15
HUP0104273A3 (en) 2003-12-29
CN1157189C (zh) 2004-07-14
DE69936845T2 (de) 2008-05-08
PL196809B1 (pl) 2008-02-29
AU3471399A (en) 1999-10-25
CY1106988T1 (el) 2012-09-26
SK15012000A3 (sk) 2001-08-06
BG104902A (en) 2001-07-31
SK285669B6 (sk) 2007-06-07
WO1999051238A1 (en) 1999-10-14
NO20004978D0 (no) 2000-10-03
PT1067933E (pt) 2007-11-15
MXPA00009840A (es) 2002-04-24
CZ20003650A3 (en) 2001-06-13
JP2002510633A (ja) 2002-04-09
NO20004978L (no) 2000-12-05
KR100603219B1 (ko) 2006-07-20
HUP0104273A2 (hu) 2002-03-28
ES2292237T3 (es) 2008-03-01
EP1067933A4 (en) 2002-12-18
US6124293A (en) 2000-09-26

Similar Documents

Publication Publication Date Title
NO328147B1 (no) Semi-syntetiske ecteinascidiner
US20080234279A1 (en) Ecteinascidins
CN113698401B (zh) β-榄香烯大环衍生物及其制备方法和应用
US6087369A (en) Indole derivatives, process for producing the same and medicinal uses of the same
ZA200407611B (en) Hemiasterlin derivatives and uses thereof in the treatment of cancer
EA014689B1 (ru) Новые соединения - аналоги камптотецина, способ их получения и фармацевтические композиции, которые их содержат
CA2225807C (en) Use of lamellarin-class alkaloids in methods of treatment
CA2205872A1 (en) Acrylamide derivatives and process for production thereof
KR20080075911A (ko) 항종양 화합물
EP0520435A2 (en) DC-89 derivatives
KR20030069993A (ko) 트리아졸로-에포틸론
CN111377854B (zh) Cxcr4抑制剂及其应用
KR20050107756A (ko) 종양 억제 활성을 갖는 캄토테신의 7-이미노 유도체
DE60209029T2 (de) Polycyclische verbindungen mit antitumor-wirkung
HK1033651B (en) Semi-synthetic ecteinascidins
WO2024245384A1 (en) Cyclophilin inhibitors and uses thereof
JP4282323B2 (ja) ストレプトグラミン誘導体、その製造およびそれを含有する組成物
CN116120327A (zh) β-榄香烯13,14-位对称的双取代衍生物及其制备方法和应用
JPH08208653A (ja) アクリルアミド誘導体及びその製造方法
WO2015158306A1 (zh) 一类乙二醛酶i不可逆抑制剂及其制备方法和用途

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees