NO327364B1 - Nitrooksyderivater av steroidforbindelser, anvendelse derav, og farmasoytisk formulering omfattende slike - Google Patents
Nitrooksyderivater av steroidforbindelser, anvendelse derav, og farmasoytisk formulering omfattende slike Download PDFInfo
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- NO327364B1 NO327364B1 NO20043595A NO20043595A NO327364B1 NO 327364 B1 NO327364 B1 NO 327364B1 NO 20043595 A NO20043595 A NO 20043595A NO 20043595 A NO20043595 A NO 20043595A NO 327364 B1 NO327364 B1 NO 327364B1
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- Prior art keywords
- budesonide
- compounds according
- following
- group
- steroid
- Prior art date
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- -1 steroid compounds Chemical class 0.000 title claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 27
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 claims description 17
- 239000002243 precursor Substances 0.000 claims description 17
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
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- 125000005647 linker group Chemical group 0.000 claims description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000148A ITMI20020148A1 (it) | 2002-01-29 | 2002-01-29 | Nuovi corticosteroidi |
| PCT/EP2003/000394 WO2003064443A2 (en) | 2002-01-29 | 2003-01-16 | New corticosteroids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20043595L NO20043595L (no) | 2004-10-20 |
| NO327364B1 true NO327364B1 (no) | 2009-06-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043595A NO327364B1 (no) | 2002-01-29 | 2004-08-27 | Nitrooksyderivater av steroidforbindelser, anvendelse derav, og farmasoytisk formulering omfattende slike |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060052594A1 (https=) |
| EP (1) | EP1470150A2 (https=) |
| JP (1) | JP2005516070A (https=) |
| AU (2) | AU2003210161B2 (https=) |
| BR (1) | BR0307027A (https=) |
| CA (1) | CA2473249A1 (https=) |
| IT (1) | ITMI20020148A1 (https=) |
| MX (1) | MXPA04007337A (https=) |
| NO (1) | NO327364B1 (https=) |
| NZ (1) | NZ534147A (https=) |
| PL (1) | PL370457A1 (https=) |
| WO (1) | WO2003064443A2 (https=) |
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| HRP20070283T3 (en) * | 2003-12-02 | 2007-11-30 | Nicox S.A. | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs |
| CN102134269A (zh) * | 2005-09-02 | 2011-07-27 | 尼科克斯公司 | 糖皮质激素硝酰氧基衍生物 |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| EP2109617A1 (en) * | 2007-02-05 | 2009-10-21 | Nicox S.A. | Nitric oxide releasing steroids |
| EP1964550A1 (en) * | 2007-03-01 | 2008-09-03 | NicOx S.A. | Glucocorticoid-nitrooxyderivative compositions |
| US20090087425A1 (en) * | 2007-08-10 | 2009-04-02 | Topigen Pharmaceuticals Inc. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
| US20090088411A1 (en) * | 2007-08-31 | 2009-04-02 | Topigen Pharmaceuticals Inc. | No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| ES2324007A1 (es) * | 2007-10-25 | 2009-07-28 | Ferrer Internacional, S.A. | Una forma amorfa de un compuesto antiinflamatorio. |
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| CN101624414B (zh) * | 2008-07-07 | 2013-02-13 | 天津金耀集团有限公司 | 一种抑制血管新生的硝酸酯药物 |
| MX2011001119A (es) | 2008-07-31 | 2011-03-02 | Nicox Sa | Glucocorticoides unidos a esteres de nitrato por medio de un enlazador aromatico en la posicion 21 y su uso en oftalmololgia. |
| JP2011529933A (ja) | 2008-08-05 | 2011-12-15 | ニコックス エス エイ | 網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド |
| CN102040643B (zh) * | 2009-10-16 | 2013-01-09 | 天津金耀集团有限公司 | 环索奈德硝酸酯衍生物 |
| US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
| ES3046537T3 (en) | 2016-11-08 | 2025-12-02 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| SG11202006510XA (en) | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| CN108484714A (zh) * | 2018-03-13 | 2018-09-04 | 岳阳环宇药业有限公司 | 地夫可特的制备工艺 |
| CN118955710A (zh) | 2018-05-09 | 2024-11-15 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1037451B (de) * | 1957-04-04 | 1958-08-28 | Schering Ag | Verfahren zur Herstellung der Aminoacetate von gesaettigten und ungesaettigten 21-Hydroxypregnan-verbindungen bzw. deren wasserloeslichen Saeureadditionsprodukten |
| US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (https=) | 1971-05-07 | 1973-12-28 | ||
| CY1359A (en) * | 1981-02-02 | 1987-08-07 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| US6248723B1 (en) * | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| US6254853B1 (en) * | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
-
2002
- 2002-01-29 IT IT2002MI000148A patent/ITMI20020148A1/it unknown
-
2003
- 2003-01-16 WO PCT/EP2003/000394 patent/WO2003064443A2/en not_active Ceased
- 2003-01-16 US US10/501,335 patent/US20060052594A1/en not_active Abandoned
- 2003-01-16 BR BR0307027-1A patent/BR0307027A/pt not_active IP Right Cessation
- 2003-01-16 NZ NZ534147A patent/NZ534147A/en not_active IP Right Cessation
- 2003-01-16 CA CA002473249A patent/CA2473249A1/en not_active Abandoned
- 2003-01-16 AU AU2003210161A patent/AU2003210161B2/en not_active Ceased
- 2003-01-16 EP EP03734674A patent/EP1470150A2/en not_active Ceased
- 2003-01-16 MX MXPA04007337A patent/MXPA04007337A/es unknown
- 2003-01-16 PL PL03370457A patent/PL370457A1/xx unknown
- 2003-01-16 JP JP2003564063A patent/JP2005516070A/ja active Pending
-
2004
- 2004-08-27 NO NO20043595A patent/NO327364B1/no not_active IP Right Cessation
-
2008
- 2008-12-15 AU AU2008258133A patent/AU2008258133A1/en not_active Abandoned
-
2009
- 2009-05-12 US US12/464,562 patent/US20090221543A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1470150A2 (en) | 2004-10-27 |
| AU2008258133A1 (en) | 2009-01-08 |
| BR0307027A (pt) | 2004-11-03 |
| WO2003064443A2 (en) | 2003-08-07 |
| CA2473249A1 (en) | 2003-08-07 |
| NO20043595L (no) | 2004-10-20 |
| MXPA04007337A (es) | 2004-11-26 |
| US20090221543A1 (en) | 2009-09-03 |
| AU2003210161B2 (en) | 2008-12-04 |
| ITMI20020148A0 (it) | 2002-01-29 |
| WO2003064443A3 (en) | 2004-02-26 |
| JP2005516070A (ja) | 2005-06-02 |
| US20060052594A1 (en) | 2006-03-09 |
| NZ534147A (en) | 2006-09-29 |
| ITMI20020148A1 (it) | 2003-07-29 |
| PL370457A1 (en) | 2005-05-30 |
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