BR0307027A - Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticas - Google Patents
Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticasInfo
- Publication number
- BR0307027A BR0307027A BR0307027-1A BR0307027A BR0307027A BR 0307027 A BR0307027 A BR 0307027A BR 0307027 A BR0307027 A BR 0307027A BR 0307027 A BR0307027 A BR 0307027A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- steroid
- nitroxy
- pharmaceutical formulations
- derived
- Prior art date
Links
- -1 Nitroxy Chemical group 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000148A ITMI20020148A1 (it) | 2002-01-29 | 2002-01-29 | Nuovi corticosteroidi |
| PCT/EP2003/000394 WO2003064443A2 (en) | 2002-01-29 | 2003-01-16 | New corticosteroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0307027A true BR0307027A (pt) | 2004-11-03 |
Family
ID=11449016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0307027-1A BR0307027A (pt) | 2002-01-29 | 2003-01-16 | Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticas |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060052594A1 (https=) |
| EP (1) | EP1470150A2 (https=) |
| JP (1) | JP2005516070A (https=) |
| AU (2) | AU2003210161B2 (https=) |
| BR (1) | BR0307027A (https=) |
| CA (1) | CA2473249A1 (https=) |
| IT (1) | ITMI20020148A1 (https=) |
| MX (1) | MXPA04007337A (https=) |
| NO (1) | NO327364B1 (https=) |
| NZ (1) | NZ534147A (https=) |
| PL (1) | PL370457A1 (https=) |
| WO (1) | WO2003064443A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20070283T3 (en) * | 2003-12-02 | 2007-11-30 | Nicox S.A. | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs |
| CN102134269A (zh) * | 2005-09-02 | 2011-07-27 | 尼科克斯公司 | 糖皮质激素硝酰氧基衍生物 |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| EP2109617A1 (en) * | 2007-02-05 | 2009-10-21 | Nicox S.A. | Nitric oxide releasing steroids |
| EP1964550A1 (en) * | 2007-03-01 | 2008-09-03 | NicOx S.A. | Glucocorticoid-nitrooxyderivative compositions |
| US20090087425A1 (en) * | 2007-08-10 | 2009-04-02 | Topigen Pharmaceuticals Inc. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
| US20090088411A1 (en) * | 2007-08-31 | 2009-04-02 | Topigen Pharmaceuticals Inc. | No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| ES2324007A1 (es) * | 2007-10-25 | 2009-07-28 | Ferrer Internacional, S.A. | Una forma amorfa de un compuesto antiinflamatorio. |
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| CN101624414B (zh) * | 2008-07-07 | 2013-02-13 | 天津金耀集团有限公司 | 一种抑制血管新生的硝酸酯药物 |
| MX2011001119A (es) | 2008-07-31 | 2011-03-02 | Nicox Sa | Glucocorticoides unidos a esteres de nitrato por medio de un enlazador aromatico en la posicion 21 y su uso en oftalmololgia. |
| JP2011529933A (ja) | 2008-08-05 | 2011-12-15 | ニコックス エス エイ | 網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド |
| CN102040643B (zh) * | 2009-10-16 | 2013-01-09 | 天津金耀集团有限公司 | 环索奈德硝酸酯衍生物 |
| US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
| ES3046537T3 (en) | 2016-11-08 | 2025-12-02 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| SG11202006510XA (en) | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| CN108484714A (zh) * | 2018-03-13 | 2018-09-04 | 岳阳环宇药业有限公司 | 地夫可特的制备工艺 |
| CN118955710A (zh) | 2018-05-09 | 2024-11-15 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1037451B (de) * | 1957-04-04 | 1958-08-28 | Schering Ag | Verfahren zur Herstellung der Aminoacetate von gesaettigten und ungesaettigten 21-Hydroxypregnan-verbindungen bzw. deren wasserloeslichen Saeureadditionsprodukten |
| US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (https=) | 1971-05-07 | 1973-12-28 | ||
| CY1359A (en) * | 1981-02-02 | 1987-08-07 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| US6248723B1 (en) * | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| US6254853B1 (en) * | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
-
2002
- 2002-01-29 IT IT2002MI000148A patent/ITMI20020148A1/it unknown
-
2003
- 2003-01-16 WO PCT/EP2003/000394 patent/WO2003064443A2/en not_active Ceased
- 2003-01-16 US US10/501,335 patent/US20060052594A1/en not_active Abandoned
- 2003-01-16 BR BR0307027-1A patent/BR0307027A/pt not_active IP Right Cessation
- 2003-01-16 NZ NZ534147A patent/NZ534147A/en not_active IP Right Cessation
- 2003-01-16 CA CA002473249A patent/CA2473249A1/en not_active Abandoned
- 2003-01-16 AU AU2003210161A patent/AU2003210161B2/en not_active Ceased
- 2003-01-16 EP EP03734674A patent/EP1470150A2/en not_active Ceased
- 2003-01-16 MX MXPA04007337A patent/MXPA04007337A/es unknown
- 2003-01-16 PL PL03370457A patent/PL370457A1/xx unknown
- 2003-01-16 JP JP2003564063A patent/JP2005516070A/ja active Pending
-
2004
- 2004-08-27 NO NO20043595A patent/NO327364B1/no not_active IP Right Cessation
-
2008
- 2008-12-15 AU AU2008258133A patent/AU2008258133A1/en not_active Abandoned
-
2009
- 2009-05-12 US US12/464,562 patent/US20090221543A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO327364B1 (no) | 2009-06-15 |
| EP1470150A2 (en) | 2004-10-27 |
| AU2008258133A1 (en) | 2009-01-08 |
| WO2003064443A2 (en) | 2003-08-07 |
| CA2473249A1 (en) | 2003-08-07 |
| NO20043595L (no) | 2004-10-20 |
| MXPA04007337A (es) | 2004-11-26 |
| US20090221543A1 (en) | 2009-09-03 |
| AU2003210161B2 (en) | 2008-12-04 |
| ITMI20020148A0 (it) | 2002-01-29 |
| WO2003064443A3 (en) | 2004-02-26 |
| JP2005516070A (ja) | 2005-06-02 |
| US20060052594A1 (en) | 2006-03-09 |
| NZ534147A (en) | 2006-09-29 |
| ITMI20020148A1 (it) | 2003-07-29 |
| PL370457A1 (en) | 2005-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: NICOX S.A. (FR) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070016104/RJ DE 07/02/2007. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |