NO985821L - Substituerte syklopentanforbindelser som er nyttige som neuraminidaseinhibitorer - Google Patents
Substituerte syklopentanforbindelser som er nyttige som neuraminidaseinhibitorerInfo
- Publication number
- NO985821L NO985821L NO985821A NO985821A NO985821L NO 985821 L NO985821 L NO 985821L NO 985821 A NO985821 A NO 985821A NO 985821 A NO985821 A NO 985821A NO 985821 L NO985821 L NO 985821L
- Authority
- NO
- Norway
- Prior art keywords
- neuraminidase inhibitors
- compounds useful
- substituted cyclopentane
- cyclopentane compounds
- influenza virus
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/02—Saturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1993096P | 1996-06-14 | 1996-06-14 | |
US4401097P | 1997-05-02 | 1997-05-02 | |
PCT/US1997/009309 WO1997047194A1 (en) | 1996-06-14 | 1997-06-13 | Substituted cyclopentane compounds useful as neuraminidase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
NO985821D0 NO985821D0 (no) | 1998-12-11 |
NO985821L true NO985821L (no) | 1999-02-10 |
NO311885B1 NO311885B1 (no) | 2002-02-11 |
Family
ID=26692776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19985821A NO311885B1 (no) | 1996-06-14 | 1998-12-11 | Substituerte syklopentanforbindelser som er nyttige som neuraminidaseinhibitorer, anvendelse av forbindelsene samtpreparat inneholdende en slik forbindelse |
Country Status (20)
Country | Link |
---|---|
US (1) | US6410594B1 (no) |
EP (1) | EP0933993B1 (no) |
JP (1) | JP3481255B2 (no) |
KR (1) | KR20000016669A (no) |
CN (1) | CN1227466A (no) |
AT (1) | ATE322163T1 (no) |
AU (1) | AU723360B2 (no) |
BR (1) | BR9711095A (no) |
CA (1) | CA2258217C (no) |
CZ (1) | CZ412898A3 (no) |
DE (1) | DE69735634T2 (no) |
DK (1) | DK0933993T3 (no) |
ES (1) | ES2263179T3 (no) |
NO (1) | NO311885B1 (no) |
NZ (1) | NZ333437A (no) |
PL (1) | PL330407A1 (no) |
PT (1) | PT933993E (no) |
RO (1) | RO121027B1 (no) |
SK (1) | SK171698A3 (no) |
WO (1) | WO1997047194A1 (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562861B1 (en) * | 1997-12-17 | 2003-05-13 | Biocryst Pharmaceuticals, Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
EP1087938A1 (en) * | 1998-04-23 | 2001-04-04 | Abbott Laboratories | Inhibitors of neuraminidases |
US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
CA2329422A1 (en) * | 1998-04-23 | 1999-10-28 | Abbott Laboratories | Pyrrolidines as inhibitors of neuraminidases |
US6455571B1 (en) * | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
AU1520300A (en) * | 1998-11-05 | 2000-05-29 | Biocryst Pharmaceuticals, Inc. | New cyclopentane and cyclopentene compounds and use for detecting influenza virus |
HUP0201873A3 (en) | 1999-06-28 | 2003-03-28 | Biocryst Pharmaceuticals Inc B | Process for preparing (-)-(1s,4r) n-protected 4-amino-2-cyclopentene-1-carboxylate esters and the intermediate |
US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
US6627396B1 (en) | 1999-10-28 | 2003-09-30 | The Regents Of The University Of California | Influenza sensor |
AU2001243253A1 (en) * | 2000-02-24 | 2001-09-03 | Biocryst Pharmaceuticals, Inc. | Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
AU2001252578A1 (en) * | 2000-04-25 | 2001-11-07 | Sankyo Company Limited | Preventives for influenza |
AUPR001000A0 (en) | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
JP4851185B2 (ja) | 2003-05-16 | 2012-01-11 | ジェレックスインターナショナル株式会社 | アレルギー症状抑制剤及び空気濾過フィルター |
US20070203241A1 (en) * | 2006-02-13 | 2007-08-30 | Babu Yarlagadda S | Antiviral treatments |
KR20230003248A (ko) * | 2006-02-13 | 2023-01-05 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | 정맥내 항바이러스 치료 |
US20070244193A1 (en) * | 2006-04-12 | 2007-10-18 | Babu Yarlagadda S | Intramuscular antiviral treatments |
US20080063722A1 (en) * | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
US20080194801A1 (en) * | 2007-02-14 | 2008-08-14 | Swanson Basil I | Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses |
IN2012CN10271A (no) * | 2010-05-27 | 2015-04-10 | Reddy’S Lab Ltd Dr | |
AT510585B1 (de) | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
CN102584637B (zh) * | 2011-01-17 | 2014-07-09 | 天津药物研究院 | 帕拉米韦水合物晶体、制备方法、药用组合物及其用途 |
CN102603577A (zh) * | 2011-01-19 | 2012-07-25 | 董慧珍 | 一种抗流感和禽流感药物的衍生物及其用途 |
CN102863359B (zh) * | 2012-05-16 | 2014-05-07 | 常州制药厂有限公司 | 一种抗流感药物的合成方法 |
CN104402754B (zh) * | 2014-11-25 | 2016-03-02 | 广东东阳光药业有限公司 | 作为神经氨酸酶抑制剂的化合物及其在药物中的应用 |
CN104387288B (zh) * | 2014-11-25 | 2016-04-20 | 广东东阳光药业有限公司 | 作为神经氨酸酶抑制剂的化合物及其在药物中的应用 |
CN104447390B (zh) * | 2014-12-03 | 2016-03-02 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496839B (zh) * | 2014-12-03 | 2016-04-20 | 广东东阳光药业有限公司 | 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途 |
CN104496857B (zh) * | 2014-12-10 | 2016-10-12 | 广东东阳光药业有限公司 | 作为神经氨酸酶抑制剂的化合物及其在药物中的应用 |
CN110128288B (zh) * | 2018-02-02 | 2023-07-28 | 浙江九洲药业股份有限公司 | 一种氨基取代的环戊烷甲酸烷基酯衍生物的制备方法 |
WO2023192165A1 (en) * | 2022-03-27 | 2023-10-05 | Tranexamic Technologies, Llc | Tranexamic class arginine and histidine mimics as therapeutic agents |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT979736B (it) | 1972-03-07 | 1974-09-30 | Ethyl Corp | Detersivo contenente un sequestran te e relativo metodo di impiego |
US4426391A (en) | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
JPS59163365A (ja) | 1983-03-08 | 1984-09-14 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物 |
EP0130119B1 (en) | 1983-06-23 | 1988-11-09 | Merck & Co. Inc. | (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives |
US4873019A (en) | 1986-12-20 | 1989-10-10 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Cyclopentane derivatives |
ATE126511T1 (de) | 1990-02-02 | 1995-09-15 | Schering Corp | 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung. |
AU1566192A (en) | 1991-03-12 | 1992-10-21 | Mect Corporation | Synthesis of sialic acid and synthetic intermediate therefor |
JP2951765B2 (ja) | 1991-09-10 | 1999-09-20 | 三共株式会社 | エナミノエステル類およびその製法 |
AU673824B2 (en) | 1992-05-29 | 1996-11-28 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-beta-amino acids |
US5453533A (en) * | 1994-04-14 | 1995-09-26 | The University Of Alabama At Birmingham | Inhibitors of influenza virus neuraminidase and methods of making and using the same |
US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
US5602277A (en) * | 1995-03-30 | 1997-02-11 | Biocryst Pharmaceuticals, Inc. | Substituted benzene derivatives useful as neuraminidase inhibitors |
CA2176414A1 (en) | 1995-05-18 | 1996-11-19 | S. David Kimball | Acyl guanidine and amidine prodrugs |
AU747293B2 (en) | 1997-02-06 | 2002-05-16 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
US6562861B1 (en) | 1997-12-17 | 2003-05-13 | Biocryst Pharmaceuticals, Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
EP1087938A1 (en) | 1998-04-23 | 2001-04-04 | Abbott Laboratories | Inhibitors of neuraminidases |
CA2329422A1 (en) | 1998-04-23 | 1999-10-28 | Abbott Laboratories | Pyrrolidines as inhibitors of neuraminidases |
-
1997
- 1997-06-13 CA CA002258217A patent/CA2258217C/en not_active Expired - Fee Related
- 1997-06-13 PT PT97931014T patent/PT933993E/pt unknown
- 1997-06-13 CZ CZ984128A patent/CZ412898A3/cs unknown
- 1997-06-13 RO RO98-01684A patent/RO121027B1/ro unknown
- 1997-06-13 ES ES97931014T patent/ES2263179T3/es not_active Expired - Lifetime
- 1997-06-13 DK DK97931014T patent/DK0933993T3/da active
- 1997-06-13 DE DE69735634T patent/DE69735634T2/de not_active Expired - Lifetime
- 1997-06-13 SK SK1716-98A patent/SK171698A3/sk unknown
- 1997-06-13 CN CN97197248A patent/CN1227466A/zh active Pending
- 1997-06-13 PL PL97330407A patent/PL330407A1/xx unknown
- 1997-06-13 AT AT97931014T patent/ATE322163T1/de active
- 1997-06-13 EP EP97931014A patent/EP0933993B1/en not_active Expired - Lifetime
- 1997-06-13 BR BR9711095-7A patent/BR9711095A/pt not_active IP Right Cessation
- 1997-06-13 JP JP50164998A patent/JP3481255B2/ja not_active Expired - Fee Related
- 1997-06-13 AU AU34750/97A patent/AU723360B2/en not_active Ceased
- 1997-06-13 KR KR1019980710269A patent/KR20000016669A/ko active IP Right Grant
- 1997-06-13 US US09/202,351 patent/US6410594B1/en not_active Expired - Lifetime
- 1997-06-13 NZ NZ333437A patent/NZ333437A/xx unknown
- 1997-06-13 WO PCT/US1997/009309 patent/WO1997047194A1/en active IP Right Grant
-
1998
- 1998-12-11 NO NO19985821A patent/NO311885B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU3475097A (en) | 1998-01-07 |
BR9711095A (pt) | 2001-07-17 |
US6410594B1 (en) | 2002-06-25 |
SK171698A3 (en) | 1999-10-08 |
ATE322163T1 (de) | 2006-04-15 |
PT933993E (pt) | 2006-10-31 |
AU723360B2 (en) | 2000-08-24 |
NZ333437A (en) | 2000-05-26 |
EP0933993A1 (en) | 1999-08-11 |
NO985821D0 (no) | 1998-12-11 |
CA2258217C (en) | 2005-08-09 |
RO121027B1 (ro) | 2006-11-30 |
JP2000505088A (ja) | 2000-04-25 |
NO311885B1 (no) | 2002-02-11 |
DE69735634D1 (de) | 2006-05-18 |
PL330407A1 (en) | 1999-05-10 |
JP3481255B2 (ja) | 2003-12-22 |
DK0933993T3 (da) | 2006-08-14 |
DE69735634T2 (de) | 2007-05-03 |
CA2258217A1 (en) | 1997-12-18 |
WO1997047194A1 (en) | 1997-12-18 |
EP0933993B1 (en) | 2006-04-05 |
ES2263179T3 (es) | 2006-12-01 |
EP0933993A4 (en) | 2004-09-08 |
CN1227466A (zh) | 1999-09-01 |
CZ412898A3 (cs) | 1999-08-11 |
KR20000016669A (ko) | 2000-03-25 |
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