ATE126511T1 - 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung. - Google Patents

4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.

Info

Publication number
ATE126511T1
ATE126511T1 AT91904114T AT91904114T ATE126511T1 AT E126511 T1 ATE126511 T1 AT E126511T1 AT 91904114 T AT91904114 T AT 91904114T AT 91904114 T AT91904114 T AT 91904114T AT E126511 T1 ATE126511 T1 AT E126511T1
Authority
AT
Austria
Prior art keywords
alkoxy
alkyl
pct
phenyl
substituted phenyl
Prior art date
Application number
AT91904114T
Other languages
English (en)
Inventor
Theodros Asberom
Edward O'connor
Joel Gilbert Berger
John Welch Clader
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE126511T1 publication Critical patent/ATE126511T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91904114T 1990-02-02 1991-01-31 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung. ATE126511T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47442890A 1990-02-02 1990-02-02

Publications (1)

Publication Number Publication Date
ATE126511T1 true ATE126511T1 (de) 1995-09-15

Family

ID=23883493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91904114T ATE126511T1 (de) 1990-02-02 1991-01-31 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.

Country Status (12)

Country Link
US (1) US5362728A (de)
EP (1) EP0513174B1 (de)
JP (1) JPH0613474B2 (de)
KR (1) KR927003537A (de)
AT (1) ATE126511T1 (de)
AU (1) AU646432B2 (de)
CA (1) CA2075181C (de)
DE (1) DE69112201T2 (de)
ES (1) ES2075429T3 (de)
FI (1) FI923458A (de)
OA (1) OA09662A (de)
WO (1) WO1991011437A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1008622A3 (fr) * 1993-12-09 1996-06-04 Egyt Gyogyszervegyeszeti Gyar Derives de l'epi-epibatidine.
PL330407A1 (en) 1996-06-14 1999-05-10 Biocryst Pharmaceuticals Substituted cyclopentane compounds useful as neuraminidaze inhibitors
AU728332B2 (en) * 1997-06-23 2001-01-04 Kioka Gaishi Kogyo Kabushiki Kaisha Lock nut and attaching/removing tool for the same
SK8712000A3 (en) * 1997-12-17 2000-11-07 Biocryst Pharm Inc Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
AU1520300A (en) 1998-11-05 2000-05-29 Biocryst Pharmaceuticals, Inc. New cyclopentane and cyclopentene compounds and use for detecting influenza virus
US7411093B2 (en) 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
US7834012B2 (en) * 2005-08-30 2010-11-16 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
EP3296289A3 (de) 2007-05-31 2018-06-20 Sunovion Pharmaceuticals Inc. Phenyl-substituierte cycloalkylamine als monoamin-wiederaufnahmehemmer
KR101913442B1 (ko) 2010-09-01 2018-10-30 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
WO2012030939A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US3752892A (en) * 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives
US4284555A (en) * 1979-04-27 1981-08-18 Schering Corporation 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4477378A (en) * 1980-02-05 1984-10-16 Schering Corp. Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
WO1987004430A2 (en) * 1986-01-16 1987-07-30 Schering Corporation Fused benzazepines
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
ZA875183B (en) * 1987-07-15 1988-04-08 Schering Corporation Fused benzazepines

Also Published As

Publication number Publication date
OA09662A (en) 1993-05-15
KR927003537A (ko) 1992-12-18
DE69112201D1 (de) 1995-09-21
US5362728A (en) 1994-11-08
CA2075181C (en) 1997-12-09
FI923458A0 (fi) 1992-07-31
DE69112201T2 (de) 1996-02-15
ES2075429T3 (es) 1995-10-01
AU646432B2 (en) 1994-02-24
CA2075181A1 (en) 1991-08-03
EP0513174B1 (de) 1995-08-16
AU7243291A (en) 1991-08-21
WO1991011437A1 (en) 1991-08-08
JPH05504769A (ja) 1993-07-22
EP0513174A1 (de) 1992-11-19
JPH0613474B2 (ja) 1994-02-23
FI923458A (fi) 1992-07-31

Similar Documents

Publication Publication Date Title
ZA928682B (en) Acyclic ethylenediamine derivatives
DE69512925D1 (de) Ortho-substituierte aromatische ether und ihre verwendung in schmerzstillenden pharmazeutischen zusammensetzungen
DE69316067T2 (de) Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus
DE69112201D1 (de) 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.
DK0572635T3 (da) Hidtil ukendte forbindelser med guanidinstruktur og farmaceutisk komposition indeholdende forbindelserne
DK0728138T3 (da) Anthracyclinderivater
DE69104475D1 (de) Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel.
FI970434A (fi) Uudet 3-substituoidut 3H-2,3-bentsodiatsepiinijohdannaiset, niiden valmistus ja käyttö lääkkeenä
HRP950437A2 (en) N-substituted azabicycloheptane derivatives, their production and use
ES8300776A1 (es) Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
DE59209494D1 (de) Aminoalkylsubstituierte 5-mercaptothiazole, ihre herstellung und verwendung
PL297368A1 (en) Novel derivatives of 2h-benzo (b) pyrane substituted with aryl or n-heteroaryl at position 4, method of obtaining them and their applications as well as preparation containing these compounds
NO305519B1 (no) Benzo[f]kinoksalindionderivater og legemidler inneholdende disse
PH31212A (en) 4-Amino-2-(hetero)aryl-butanamides useful as 5-HT1a-antagonists.
ES8704477A1 (es) Procedimiento para preparar piridin-1-oxidos varias veces substituidos
FR2695643B1 (fr) Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant.
IT1261958B (it) 2-(sostituite immino)-tiazolidine e procedimento per la loro preparazione e loro impiego quali antianginose e/o analgesiche
NO923042L (no) 4,5-cykloalkano-3-benzazepin-7-ol-derivater og deres anvendelse
TH17166A (th) ฟีนิลอมิโนซัลโฟนิลยูเรียที่ถูกแทนที่สำหรับฆ่าวัชพืช

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties