DE69316067T2 - Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus - Google Patents
Arzneimittel zur Verwendung bei der Behandlung von ParkinsonismusInfo
- Publication number
- DE69316067T2 DE69316067T2 DE69316067T DE69316067T DE69316067T2 DE 69316067 T2 DE69316067 T2 DE 69316067T2 DE 69316067 T DE69316067 T DE 69316067T DE 69316067 T DE69316067 T DE 69316067T DE 69316067 T2 DE69316067 T2 DE 69316067T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- carbon atoms
- treatment
- aryl
- heterocyclic group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8711592 | 1992-04-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69316067D1 DE69316067D1 (de) | 1998-02-12 |
DE69316067T2 true DE69316067T2 (de) | 1998-07-02 |
Family
ID=13905960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69316067T Expired - Lifetime DE69316067T2 (de) | 1992-04-08 | 1993-04-08 | Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0565377B1 (de) |
JP (1) | JP2613352B2 (de) |
AT (1) | ATE161723T1 (de) |
BR (1) | BR1100636A (de) |
CA (1) | CA2093403C (de) |
DE (1) | DE69316067T2 (de) |
DK (1) | DK0565377T3 (de) |
ES (1) | ES2112386T3 (de) |
GR (1) | GR3026233T3 (de) |
HK (1) | HK1001835A1 (de) |
NO (1) | NO303265B1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2106771C (en) * | 1992-02-19 | 2004-11-02 | Yukio Ishida | Highly water absorbed rice, method for producing same and application of same |
JP2928386B2 (ja) * | 1992-07-08 | 1999-08-03 | 協和醗酵工業株式会社 | うつ病治療剤 |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
AU6781194A (en) * | 1993-05-03 | 1994-11-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
ZA945609B (en) * | 1993-07-28 | 1995-05-12 | Rhone Poulenc Rorer Ltd | [Di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds |
US5703085A (en) * | 1994-02-23 | 1997-12-30 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
WO1998005334A1 (en) * | 1996-08-07 | 1998-02-12 | Kyowa Hakko Kogyo Co., Ltd. | Fat emulsion containing xanthine derivative |
ATE325610T1 (de) | 1997-09-05 | 2006-06-15 | Kyowa Hakko Kogyo Kk | Xanthinderivative zur behandlung von hirnischämie |
EP2336133A1 (de) | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purinanaloga mit HSP90-inhibierender Wirkung |
WO2004096228A1 (en) | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
BRPI0414533A (pt) | 2003-09-18 | 2006-11-07 | Conforma Therapeutics Corp | composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90 |
CA2554426C (en) | 2004-01-28 | 2012-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Agents for treating migraine |
EP1869027A4 (de) | 2005-03-30 | 2010-06-23 | Conforma Therapeutics Corp | Alkynyl-pyrrolopyrimidine und entsprechende analoga als hsp90-hemmer |
CA2608111A1 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
MX2009006346A (es) * | 2006-12-22 | 2010-03-03 | Sanol Arznei Schwarz Gmbh | Derivados de 8-etinilxantina como antagonistas de receptores de a2a selectivos. |
US7994357B2 (en) * | 2009-04-03 | 2011-08-09 | Naturewise Biotech & Medicals Corporation | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase |
WO2020125779A1 (en) * | 2018-12-21 | 2020-06-25 | Sunshine Lake Pharma Co., Ltd. | 8-substituted styryl xanthine derivatives and uses thereof |
WO2020216152A1 (en) * | 2019-04-24 | 2020-10-29 | Dongguan Hec New Drug R&D Co., Ltd. | 8-substituted aryl vinyl xanthine derivatives and uses thereof |
CN110041331B (zh) * | 2019-05-17 | 2020-08-07 | 广东东阳光药业有限公司 | 苯乙烯基黄嘌呤衍生物及其用途 |
CN112409360B (zh) * | 2019-08-22 | 2022-12-23 | 广东东阳光药业有限公司 | 杂芳基乙烯基黄嘌呤衍生物及其用途 |
CN112300165B (zh) * | 2019-11-11 | 2022-03-04 | 广东东阳光药业有限公司 | 8-取代的苯乙烯基黄嘌呤衍生物及其用途 |
CN111018856B (zh) * | 2019-12-12 | 2021-10-01 | 广东东阳光药业有限公司 | 8-取代的苯乙烯基黄嘌呤衍生物及其用途 |
CN111072663B (zh) * | 2019-12-12 | 2021-10-01 | 广东东阳光药业有限公司 | 8-取代的苯乙烯基黄嘌呤衍生物及其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7011094A (de) * | 1969-07-30 | 1971-02-02 | ||
DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
GB8906792D0 (en) * | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
FR2665636B1 (fr) * | 1990-08-10 | 1994-10-07 | Adir | Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer. |
WO1992006976A1 (fr) * | 1990-10-18 | 1992-04-30 | Kyowa Hakko Kogyo Co., Ltd. | Derive de xanthine |
-
1993
- 1993-04-05 CA CA002093403A patent/CA2093403C/en not_active Expired - Lifetime
- 1993-04-06 NO NO931317A patent/NO303265B1/no not_active IP Right Cessation
- 1993-04-08 DK DK93302780.7T patent/DK0565377T3/da active
- 1993-04-08 ES ES93302780T patent/ES2112386T3/es not_active Expired - Lifetime
- 1993-04-08 EP EP93302780A patent/EP0565377B1/de not_active Expired - Lifetime
- 1993-04-08 AT AT93302780T patent/ATE161723T1/de not_active IP Right Cessation
- 1993-04-08 DE DE69316067T patent/DE69316067T2/de not_active Expired - Lifetime
- 1993-04-08 JP JP5081953A patent/JP2613352B2/ja not_active Expired - Fee Related
-
1997
- 1997-05-13 BR BR1100636-6A patent/BR1100636A/pt active IP Right Grant
-
1998
- 1998-02-04 HK HK98100812A patent/HK1001835A1/xx not_active IP Right Cessation
- 1998-02-25 GR GR980400413T patent/GR3026233T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0565377A1 (de) | 1993-10-13 |
JP2613352B2 (ja) | 1997-05-28 |
GR3026233T3 (en) | 1998-05-29 |
JPH0616559A (ja) | 1994-01-25 |
CA2093403C (en) | 1999-08-10 |
HK1001835A1 (en) | 1998-07-10 |
CA2093403A1 (en) | 1993-10-09 |
EP0565377B1 (de) | 1998-01-07 |
ES2112386T3 (es) | 1998-04-01 |
ATE161723T1 (de) | 1998-01-15 |
NO931317D0 (no) | 1993-04-06 |
DK0565377T3 (da) | 1998-03-16 |
NO931317L (no) | 1993-10-11 |
DE69316067D1 (de) | 1998-02-12 |
BR1100636A (pt) | 2000-04-18 |
NO303265B1 (no) | 1998-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: KYOWA HAKKO KIRIN CO., LTD., TOKYO, JP |