ATE270268T1 - 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren - Google Patents
2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitorenInfo
- Publication number
- ATE270268T1 ATE270268T1 AT00927038T AT00927038T ATE270268T1 AT E270268 T1 ATE270268 T1 AT E270268T1 AT 00927038 T AT00927038 T AT 00927038T AT 00927038 T AT00927038 T AT 00927038T AT E270268 T1 ATE270268 T1 AT E270268T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- arylalkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30077999A | 1999-04-27 | 1999-04-27 | |
US38870099A | 1999-09-02 | 1999-09-02 | |
PCT/EP2000/003688 WO2000064863A1 (en) | 1999-04-27 | 2000-04-25 | Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE270268T1 true ATE270268T1 (de) | 2004-07-15 |
Family
ID=26971977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00927038T ATE270268T1 (de) | 1999-04-27 | 2000-04-25 | 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren |
Country Status (13)
Country | Link |
---|---|
US (1) | US20050026994A1 (de) |
EP (1) | EP1173413B1 (de) |
JP (1) | JP2002543058A (de) |
CN (1) | CN100357267C (de) |
AT (1) | ATE270268T1 (de) |
AU (1) | AU4555800A (de) |
BR (1) | BR0010134A (de) |
CA (1) | CA2370830C (de) |
DE (1) | DE60011889T2 (de) |
ES (1) | ES2223512T3 (de) |
HK (1) | HK1044931A1 (de) |
PT (1) | PT1173413E (de) |
WO (1) | WO2000064863A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU49055B (sh) | 1996-04-25 | 2003-08-29 | Milenko dipl.ing. Pupović | Sto za nameštanje kičme |
GB0012795D0 (en) * | 2000-05-25 | 2000-07-19 | Novartis Ag | Organic compounds |
US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
CN1509462A (zh) | 2001-05-21 | 2004-06-30 | NF-κB抑制剂在治疗干眼疾病中的用途 | |
PT1392355E (pt) | 2001-05-21 | 2007-03-30 | Alcon Inc | Utilização de inibidores do proteassoma para tratar distúrbios associados à secura ocular |
US7112588B2 (en) | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
EP1637529A1 (de) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Neue Piperidin-4-yl-Thiazol-Carboxamid-Analog als Inhibitoren für die Vermehrung von T-Zellen und ihre Verwendung |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US8459852B2 (en) | 2007-10-05 | 2013-06-11 | Dental Equipment, Llc | LED-based dental exam lamp |
CA2785300A1 (en) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
WO2018143145A1 (ja) * | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5344634A (en) * | 1976-10-01 | 1978-04-21 | Kyowa Hakko Kogyo Co Ltd | Carcinostatic agent |
MX9203836A (es) * | 1991-07-02 | 1993-01-01 | Sandoz Ag | Derivados de acido-4-amino-3-hidroxicarboxilico y proceso para su preparacion. |
US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
DE4331135A1 (de) * | 1993-09-14 | 1995-03-16 | Bayer Ag | Neue antiviral wirksame valinhaltige Pseudopeptide |
-
2000
- 2000-04-25 CN CNB00807741XA patent/CN100357267C/zh not_active Expired - Fee Related
- 2000-04-25 AU AU45558/00A patent/AU4555800A/en not_active Abandoned
- 2000-04-25 EP EP00927038A patent/EP1173413B1/de not_active Expired - Lifetime
- 2000-04-25 PT PT00927038T patent/PT1173413E/pt unknown
- 2000-04-25 JP JP2000613816A patent/JP2002543058A/ja active Pending
- 2000-04-25 ES ES00927038T patent/ES2223512T3/es not_active Expired - Lifetime
- 2000-04-25 DE DE60011889T patent/DE60011889T2/de not_active Expired - Fee Related
- 2000-04-25 BR BR0010134-6A patent/BR0010134A/pt not_active Application Discontinuation
- 2000-04-25 AT AT00927038T patent/ATE270268T1/de not_active IP Right Cessation
- 2000-04-25 CA CA002370830A patent/CA2370830C/en not_active Expired - Fee Related
- 2000-04-25 WO PCT/EP2000/003688 patent/WO2000064863A1/en active IP Right Grant
-
2001
- 2001-10-25 US US10/035,301 patent/US20050026994A1/en not_active Abandoned
-
2002
- 2002-06-19 HK HK02104585A patent/HK1044931A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60011889T2 (de) | 2005-07-14 |
EP1173413A1 (de) | 2002-01-23 |
CN100357267C (zh) | 2007-12-26 |
DE60011889D1 (en) | 2004-08-05 |
HK1044931A1 (en) | 2002-11-08 |
EP1173413B1 (de) | 2004-06-30 |
BR0010134A (pt) | 2002-01-15 |
JP2002543058A (ja) | 2002-12-17 |
AU4555800A (en) | 2000-11-10 |
CN1351587A (zh) | 2002-05-29 |
CA2370830A1 (en) | 2000-11-02 |
PT1173413E (pt) | 2004-10-29 |
ES2223512T3 (es) | 2005-03-01 |
WO2000064863A1 (en) | 2000-11-02 |
US20050026994A1 (en) | 2005-02-03 |
CA2370830C (en) | 2009-10-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE270268T1 (de) | 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren | |
NO882036L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner. | |
ATE396988T1 (de) | Chinolin- und chianzolinderivate zur behandlung von tumoren | |
HUP0303146A2 (hu) | Protein kináz gátló hatású 3-(4-amido-pirrol-2-il-metilidén)-2-indolinon származékok és ezeket tartalmazó gyógyszerkészítmények | |
HUP0203228A2 (hu) | Szubsztituált indolszármazékok az NFKB-aktivitás módosítására, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DK0590919T3 (da) | Terapeutiske midler mod Parkinsons sygdom | |
HUP0400710A2 (hu) | Tioéter helyettesítővel helyettesített imidazokinolinszármazékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
DE69529614T2 (de) | Heterobizyklische derivate | |
HUP0105414A2 (hu) | Pirrolo-izokinolin-, azepino- és diazepino-indol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
RU2003116648A (ru) | Замещенные имидазопиридины | |
HUP0203142A2 (hu) | Benzodiazepinszármazékok, eljárás a vegyületek előállítására, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
DE69316067T2 (de) | Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus | |
FI945538A0 (fi) | 7-(2-Aminoetyyli)-bentsotiatsolonit | |
JP2005538111A5 (de) | ||
FR2800735B1 (fr) | Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation | |
RU2006130865A (ru) | Производные пирролопиримидина, применяемые для лечения пролиферативных заболеваний | |
ES2106439T3 (es) | 5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio. | |
DE69315363D1 (de) | Amphotere tricyclische Verbindungen als antihistaminische und antiallergische Mittel | |
DE69827706D1 (de) | 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems | |
ATE311182T1 (de) | Benzopyranderivate zur behandlung von perihperer gefässerkrankung | |
TH58670B (th) | อนุพันธ์ 2-อะมิโน-3-(แอลคิล)-พิริมิโดน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1173413 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |