BR0010134A - Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma - Google Patents
Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassomaInfo
- Publication number
- BR0010134A BR0010134A BR0010134-6A BR0010134A BR0010134A BR 0010134 A BR0010134 A BR 0010134A BR 0010134 A BR0010134 A BR 0010134A BR 0010134 A BR0010134 A BR 0010134A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- arylalkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Petente de Invenção: "USO DE DERIVADOS DE áCIDO 2,4-DIAMINO-3-HIDROXICARBOXìLICO COMO INIBIDORES DE PROTEASSOMA". A presente invenção refere-se ao uso de ácidos 2,4-diamino-3-hidroxicarboxílicos de fórmula I no qual A e B representam, independentemente, uma ligação ou porção aminoacila não substituída ou substituída R~ 1~ representa hidrogênio, um grupo amino protetor ou um grupo de fórmula R~ 5~Y - em que R~ 5~ representa fidrogênio ou grupo alquila, alquenila, alquinila, arila, arilalquila, heteroarila, heteroarila, heteroarila, heteroarilalquila, heterociclila, ou heterociclilalquila; não substituído ou substituído, e Y representa -CO-, -NH-CO-, -NHCS-, -SO~ 2~-, -O-CO-, ou -O-CS-; R~ 2~ representa a cadeia lateral de um aminoácido natural, um grupo alquila, arilalquila, heteroarrilalquila ou cicloalquilalquila, ou trimetilsilil-metila, 2-tienilmetila ou estirilmetila; R~ 3~ representa halogênio, alquila, alcóxi ou hidroxialcóxi e R~ 4~ representa 2(R)-hidroxiindan-1(S)-ila (S)-2-hidróxi-1-feniletila; ou 2-hidróxi-benzila não substituída ou substituída na posição 4 por metóxi; na produção de uma composição farmacêutica para tratamento de uma doença proliferativa, por exemplo, de um tumor sólido, a um método de tratamento de animais de sangue quente; e a ácidos 2,4-diamino-3-hidroxicarboxílicos de fórmula I<sym> em que: A e B representam independentemente, uma porção aminoacila não substituída ou substituída; R~ 2~ representa arilalquila; R~ 3~ representa halogênio, alquila, alcóxi ou hidroxialcóxi, R~ 4~ representa 2-hidróxi-benzila não substituída ou substituída na posição 4 por metóxi e R~ 5~ representa arilalquila e Y representa -CO-; ou R~ 5~ representa alquila substituída por cicloalquila, naftila, piridita ou fenila em que fenila é substituída por alquila ou amino; e Y representa -O-CO-; sais farmaceuticamente aceitáveis destes e o uso de tais compostos de fórmula I<sym> no tratamento terapêutico do corpo do ser humano ou animal, especialmente para o tratamento de doenças proliferativas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30077999A | 1999-04-27 | 1999-04-27 | |
| US38870099A | 1999-09-02 | 1999-09-02 | |
| PCT/EP2000/003688 WO2000064863A1 (en) | 1999-04-27 | 2000-04-25 | Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010134A true BR0010134A (pt) | 2002-01-15 |
Family
ID=26971977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010134-6A BR0010134A (pt) | 1999-04-27 | 2000-04-25 | Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050026994A1 (pt) |
| EP (1) | EP1173413B1 (pt) |
| JP (1) | JP2002543058A (pt) |
| CN (1) | CN100357267C (pt) |
| AT (1) | ATE270268T1 (pt) |
| AU (1) | AU4555800A (pt) |
| BR (1) | BR0010134A (pt) |
| CA (1) | CA2370830C (pt) |
| DE (1) | DE60011889T2 (pt) |
| ES (1) | ES2223512T3 (pt) |
| HK (1) | HK1044931A1 (pt) |
| PT (1) | PT1173413E (pt) |
| WO (1) | WO2000064863A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU49055B (sh) | 1996-04-25 | 2003-08-29 | Milenko dipl.ing. Pupović | Sto za nameštanje kičme |
| GB0012795D0 (en) * | 2000-05-25 | 2000-07-19 | Novartis Ag | Organic compounds |
| US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
| DE60218153T2 (de) | 2001-05-21 | 2007-06-28 | Alcon Inc. | Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges |
| US6696453B2 (en) | 2001-05-21 | 2004-02-24 | Alcon, Inc. | Use of NF-κB inhibitors to treat dry eye disorders |
| US7112588B2 (en) | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
| US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| EP1637529A1 (en) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US8459852B2 (en) | 2007-10-05 | 2013-06-11 | Dental Equipment, Llc | LED-based dental exam lamp |
| JP5783659B2 (ja) | 2009-12-22 | 2015-09-24 | セファロン、インク． | プロテアソーム阻害剤およびその調製、精製および使用のための方法 |
| JP7187323B2 (ja) * | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5344634A (en) * | 1976-10-01 | 1978-04-21 | Kyowa Hakko Kogyo Co Ltd | Carcinostatic agent |
| CA2109326A1 (en) * | 1991-07-02 | 1993-01-03 | Andreas Billich | 4-amino-3-hydroxycarboxylic acid derivatives |
| US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
| DE4331135A1 (de) * | 1993-09-14 | 1995-03-16 | Bayer Ag | Neue antiviral wirksame valinhaltige Pseudopeptide |
-
2000
- 2000-04-25 EP EP00927038A patent/EP1173413B1/en not_active Expired - Lifetime
- 2000-04-25 ES ES00927038T patent/ES2223512T3/es not_active Expired - Lifetime
- 2000-04-25 WO PCT/EP2000/003688 patent/WO2000064863A1/en active IP Right Grant
- 2000-04-25 AU AU45558/00A patent/AU4555800A/en not_active Abandoned
- 2000-04-25 CA CA002370830A patent/CA2370830C/en not_active Expired - Fee Related
- 2000-04-25 AT AT00927038T patent/ATE270268T1/de not_active IP Right Cessation
- 2000-04-25 BR BR0010134-6A patent/BR0010134A/pt not_active Application Discontinuation
- 2000-04-25 CN CNB00807741XA patent/CN100357267C/zh not_active Expired - Fee Related
- 2000-04-25 JP JP2000613816A patent/JP2002543058A/ja active Pending
- 2000-04-25 PT PT00927038T patent/PT1173413E/pt unknown
- 2000-04-25 DE DE60011889T patent/DE60011889T2/de not_active Expired - Fee Related
-
2001
- 2001-10-25 US US10/035,301 patent/US20050026994A1/en not_active Abandoned
-
2002
- 2002-06-19 HK HK02104585A patent/HK1044931A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1173413B1 (en) | 2004-06-30 |
| CA2370830C (en) | 2009-10-13 |
| AU4555800A (en) | 2000-11-10 |
| DE60011889D1 (en) | 2004-08-05 |
| EP1173413A1 (en) | 2002-01-23 |
| WO2000064863A1 (en) | 2000-11-02 |
| DE60011889T2 (de) | 2005-07-14 |
| ES2223512T3 (es) | 2005-03-01 |
| ATE270268T1 (de) | 2004-07-15 |
| CN1351587A (zh) | 2002-05-29 |
| PT1173413E (pt) | 2004-10-29 |
| CA2370830A1 (en) | 2000-11-02 |
| CN100357267C (zh) | 2007-12-26 |
| JP2002543058A (ja) | 2002-12-17 |
| US20050026994A1 (en) | 2005-02-03 |
| HK1044931A1 (en) | 2002-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |