BR0010134A - Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma - Google Patents

Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma

Info

Publication number
BR0010134A
BR0010134A BR0010134-6A BR0010134A BR0010134A BR 0010134 A BR0010134 A BR 0010134A BR 0010134 A BR0010134 A BR 0010134A BR 0010134 A BR0010134 A BR 0010134A
Authority
BR
Brazil
Prior art keywords
substituted
alkyl
unsubstituted
arylalkyl
formula
Prior art date
Application number
BR0010134-6A
Other languages
English (en)
Inventor
Dennis France
Peter Fuerst
Johann Zimmermann
Carlos Garcia-Echeverria
Dieter Scholz
Pascal Furet
Patricia Imbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0010134A publication Critical patent/BR0010134A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Petente de Invenção: "USO DE DERIVADOS DE áCIDO 2,4-DIAMINO-3-HIDROXICARBOXìLICO COMO INIBIDORES DE PROTEASSOMA". A presente invenção refere-se ao uso de ácidos 2,4-diamino-3-hidroxicarboxílicos de fórmula I no qual A e B representam, independentemente, uma ligação ou porção aminoacila não substituída ou substituída R~ 1~ representa hidrogênio, um grupo amino protetor ou um grupo de fórmula R~ 5~Y - em que R~ 5~ representa fidrogênio ou grupo alquila, alquenila, alquinila, arila, arilalquila, heteroarila, heteroarila, heteroarila, heteroarilalquila, heterociclila, ou heterociclilalquila; não substituído ou substituído, e Y representa -CO-, -NH-CO-, -NHCS-, -SO~ 2~-, -O-CO-, ou -O-CS-; R~ 2~ representa a cadeia lateral de um aminoácido natural, um grupo alquila, arilalquila, heteroarrilalquila ou cicloalquilalquila, ou trimetilsilil-metila, 2-tienilmetila ou estirilmetila; R~ 3~ representa halogênio, alquila, alcóxi ou hidroxialcóxi e R~ 4~ representa 2(R)-hidroxiindan-1(S)-ila (S)-2-hidróxi-1-feniletila; ou 2-hidróxi-benzila não substituída ou substituída na posição 4 por metóxi; na produção de uma composição farmacêutica para tratamento de uma doença proliferativa, por exemplo, de um tumor sólido, a um método de tratamento de animais de sangue quente; e a ácidos 2,4-diamino-3-hidroxicarboxílicos de fórmula I<sym> em que: A e B representam independentemente, uma porção aminoacila não substituída ou substituída; R~ 2~ representa arilalquila; R~ 3~ representa halogênio, alquila, alcóxi ou hidroxialcóxi, R~ 4~ representa 2-hidróxi-benzila não substituída ou substituída na posição 4 por metóxi e R~ 5~ representa arilalquila e Y representa -CO-; ou R~ 5~ representa alquila substituída por cicloalquila, naftila, piridita ou fenila em que fenila é substituída por alquila ou amino; e Y representa -O-CO-; sais farmaceuticamente aceitáveis destes e o uso de tais compostos de fórmula I<sym> no tratamento terapêutico do corpo do ser humano ou animal, especialmente para o tratamento de doenças proliferativas.
BR0010134-6A 1999-04-27 2000-04-25 Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma BR0010134A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30077999A 1999-04-27 1999-04-27
US38870099A 1999-09-02 1999-09-02
PCT/EP2000/003688 WO2000064863A1 (en) 1999-04-27 2000-04-25 Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors

Publications (1)

Publication Number Publication Date
BR0010134A true BR0010134A (pt) 2002-01-15

Family

ID=26971977

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010134-6A BR0010134A (pt) 1999-04-27 2000-04-25 Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma

Country Status (13)

Country Link
US (1) US20050026994A1 (pt)
EP (1) EP1173413B1 (pt)
JP (1) JP2002543058A (pt)
CN (1) CN100357267C (pt)
AT (1) ATE270268T1 (pt)
AU (1) AU4555800A (pt)
BR (1) BR0010134A (pt)
CA (1) CA2370830C (pt)
DE (1) DE60011889T2 (pt)
ES (1) ES2223512T3 (pt)
HK (1) HK1044931A1 (pt)
PT (1) PT1173413E (pt)
WO (1) WO2000064863A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU49055B (sh) 1996-04-25 2003-08-29 Milenko dipl.ing. Pupović Sto za nameštanje kičme
GB0012795D0 (en) * 2000-05-25 2000-07-19 Novartis Ag Organic compounds
CN1509462A (zh) 2001-05-21 2004-06-30 NF-κB抑制剂在治疗干眼疾病中的用途
PT1392355E (pt) 2001-05-21 2007-03-30 Alcon Inc Utilização de inibidores do proteassoma para tratar distúrbios associados à secura ocular
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1637529A1 (en) * 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US8459852B2 (en) 2007-10-05 2013-06-11 Dental Equipment, Llc LED-based dental exam lamp
CN102725300B (zh) 2009-12-22 2015-03-11 赛福伦公司 蛋白酶体抑制剂及其制备、纯化、和应用的方法
WO2018143145A1 (ja) * 2017-01-31 2018-08-09 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344634A (en) * 1976-10-01 1978-04-21 Kyowa Hakko Kogyo Co Ltd Carcinostatic agent
CA2109326A1 (en) * 1991-07-02 1993-01-03 Andreas Billich 4-amino-3-hydroxycarboxylic acid derivatives
US5538997A (en) * 1993-03-12 1996-07-23 Sandoz Ltd. 2,4-diamino-3-hydroxycarboxylic acid derivatives
DE4331135A1 (de) * 1993-09-14 1995-03-16 Bayer Ag Neue antiviral wirksame valinhaltige Pseudopeptide

Also Published As

Publication number Publication date
EP1173413A1 (en) 2002-01-23
PT1173413E (pt) 2004-10-29
HK1044931A1 (en) 2002-11-08
ES2223512T3 (es) 2005-03-01
DE60011889T2 (de) 2005-07-14
JP2002543058A (ja) 2002-12-17
CN1351587A (zh) 2002-05-29
EP1173413B1 (en) 2004-06-30
AU4555800A (en) 2000-11-10
CA2370830C (en) 2009-10-13
US20050026994A1 (en) 2005-02-03
WO2000064863A1 (en) 2000-11-02
ATE270268T1 (de) 2004-07-15
CN100357267C (zh) 2007-12-26
CA2370830A1 (en) 2000-11-02
DE60011889D1 (en) 2004-08-05

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements