HK1044931A1 - Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors. - Google Patents

Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors.

Info

Publication number
HK1044931A1
HK1044931A1 HK02104585A HK02104585A HK1044931A1 HK 1044931 A1 HK1044931 A1 HK 1044931A1 HK 02104585 A HK02104585 A HK 02104585A HK 02104585 A HK02104585 A HK 02104585A HK 1044931 A1 HK1044931 A1 HK 1044931A1
Authority
HK
Hong Kong
Prior art keywords
substituted
alkyl
unsubstituted
arylalkyl
formula
Prior art date
Application number
HK02104585A
Other languages
English (en)
Inventor
Dennis France
Peter Furst
Johann Zimmermann
Carlos Garcia-Echeverria
Dieter Scholz
Pascal Furet
Patricia Imbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1044931A1 publication Critical patent/HK1044931A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
HK02104585A 1999-04-27 2002-06-19 Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors. HK1044931A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30077999A 1999-04-27 1999-04-27
US38870099A 1999-09-02 1999-09-02
PCT/EP2000/003688 WO2000064863A1 (en) 1999-04-27 2000-04-25 Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1044931A1 true HK1044931A1 (en) 2002-11-08

Family

ID=26971977

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104585A HK1044931A1 (en) 1999-04-27 2002-06-19 Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors.

Country Status (13)

Country Link
US (1) US20050026994A1 (xx)
EP (1) EP1173413B1 (xx)
JP (1) JP2002543058A (xx)
CN (1) CN100357267C (xx)
AT (1) ATE270268T1 (xx)
AU (1) AU4555800A (xx)
BR (1) BR0010134A (xx)
CA (1) CA2370830C (xx)
DE (1) DE60011889T2 (xx)
ES (1) ES2223512T3 (xx)
HK (1) HK1044931A1 (xx)
PT (1) PT1173413E (xx)
WO (1) WO2000064863A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU49055B (sh) 1996-04-25 2003-08-29 Milenko dipl.ing. Pupović Sto za nameštanje kičme
GB0012795D0 (en) * 2000-05-25 2000-07-19 Novartis Ag Organic compounds
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
PT1393277E (pt) 2001-05-21 2006-09-29 Alcon Inc Utilizacao de inibidores de nf-kb para tratar disturbios de olho seco
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
CA2447909C (en) 2001-05-21 2011-04-05 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1637529A1 (en) 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US8459852B2 (en) 2007-10-05 2013-06-11 Dental Equipment, Llc LED-based dental exam lamp
CN102725300B (zh) 2009-12-22 2015-03-11 赛福伦公司 蛋白酶体抑制剂及其制备、纯化、和应用的方法
JP7187323B2 (ja) * 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344634A (en) * 1976-10-01 1978-04-21 Kyowa Hakko Kogyo Co Ltd Carcinostatic agent
AU2194492A (en) * 1991-07-02 1993-02-11 Sandoz Ltd. 4-amino-3-hydroxycarboxylic acid derivatives
US5538997A (en) * 1993-03-12 1996-07-23 Sandoz Ltd. 2,4-diamino-3-hydroxycarboxylic acid derivatives
DE4331135A1 (de) * 1993-09-14 1995-03-16 Bayer Ag Neue antiviral wirksame valinhaltige Pseudopeptide

Also Published As

Publication number Publication date
DE60011889T2 (de) 2005-07-14
CN1351587A (zh) 2002-05-29
PT1173413E (pt) 2004-10-29
EP1173413B1 (en) 2004-06-30
CA2370830C (en) 2009-10-13
WO2000064863A1 (en) 2000-11-02
CA2370830A1 (en) 2000-11-02
CN100357267C (zh) 2007-12-26
AU4555800A (en) 2000-11-10
ES2223512T3 (es) 2005-03-01
JP2002543058A (ja) 2002-12-17
US20050026994A1 (en) 2005-02-03
BR0010134A (pt) 2002-01-15
ATE270268T1 (de) 2004-07-15
EP1173413A1 (en) 2002-01-23
DE60011889D1 (en) 2004-08-05

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110425