NO303265B1 - Xantinderivater samt anvendelse av xantinderivater for fremstilling av et terapeutisk middel mot Parkinson's sykdom - Google Patents

Xantinderivater samt anvendelse av xantinderivater for fremstilling av et terapeutisk middel mot Parkinson's sykdom

Info

Publication number
NO303265B1
NO303265B1 NO931317A NO931317A NO303265B1 NO 303265 B1 NO303265 B1 NO 303265B1 NO 931317 A NO931317 A NO 931317A NO 931317 A NO931317 A NO 931317A NO 303265 B1 NO303265 B1 NO 303265B1
Authority
NO
Norway
Prior art keywords
xanthine derivatives
group
parkinson
disease
preparation
Prior art date
Application number
NO931317A
Other languages
English (en)
Norwegian (no)
Other versions
NO931317L (no
NO931317D0 (no
Inventor
Fumio Suzuki
Junichi Shimada
Akio Ishii
Shunji Ichikawa
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of NO931317D0 publication Critical patent/NO931317D0/no
Publication of NO931317L publication Critical patent/NO931317L/no
Publication of NO303265B1 publication Critical patent/NO303265B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO931317A 1992-04-08 1993-04-06 Xantinderivater samt anvendelse av xantinderivater for fremstilling av et terapeutisk middel mot Parkinson's sykdom NO303265B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8711592 1992-04-08

Publications (3)

Publication Number Publication Date
NO931317D0 NO931317D0 (no) 1993-04-06
NO931317L NO931317L (no) 1993-10-11
NO303265B1 true NO303265B1 (no) 1998-06-22

Family

ID=13905960

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931317A NO303265B1 (no) 1992-04-08 1993-04-06 Xantinderivater samt anvendelse av xantinderivater for fremstilling av et terapeutisk middel mot Parkinson's sykdom

Country Status (11)

Country Link
EP (1) EP0565377B1 (de)
JP (1) JP2613352B2 (de)
AT (1) ATE161723T1 (de)
BR (1) BR1100636A (de)
CA (1) CA2093403C (de)
DE (1) DE69316067T2 (de)
DK (1) DK0565377T3 (de)
ES (1) ES2112386T3 (de)
GR (1) GR3026233T3 (de)
HK (1) HK1001835A1 (de)
NO (1) NO303265B1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016604A1 (en) * 1992-02-19 1993-09-02 Yukio Ishida Highly water absorbing rice, method of manufacturing same and utilization thereof
EP0628311B1 (de) * 1992-07-08 2002-04-24 Kyowa Hakko Kogyo Co., Ltd. Xanthine-Derivate als Antidepressiva
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
WO1994025462A1 (en) * 1993-05-03 1994-11-10 The United States Of America, Represented By The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
DE69430747T2 (de) * 1993-07-28 2003-03-06 Aventis Pharma Ltd., West Malling Verbindungen als pde iv und tnf inhibitoren
EP0698607B1 (de) * 1994-02-23 2002-05-29 Kyowa Hakko Kogyo Kabushiki Kaisha Xanthin-derivate
NZ334299A (en) * 1996-08-07 1999-05-28 Kyowa Hakko Kogyo Kk Fat emulsion containing xanthine derivative
ATE325610T1 (de) 1997-09-05 2006-06-15 Kyowa Hakko Kogyo Kk Xanthinderivative zur behandlung von hirnischämie
EP1440072A4 (de) 2001-10-30 2005-02-02 Conforma Therapeutic Corp Purinanaloga mit hsp90-inhibierender wirkung
AU2004233852A1 (en) 2003-04-25 2004-11-11 Novacardia, Inc. Method of improved diuresis in individuals with impaired renal function
AU2004274507B2 (en) 2003-09-18 2010-08-19 Conforma Therapeutics Corporation Novel heterocyclic compounds as HSP90-inhibitors
JP4714024B2 (ja) 2004-01-28 2011-06-29 協和発酵キリン株式会社 片頭痛の治療剤
KR20080004550A (ko) * 2005-03-30 2008-01-09 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체
WO2006115690A2 (en) * 2005-04-22 2006-11-02 Novacardia, Inc. Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions
MX2009006346A (es) * 2006-12-22 2010-03-03 Sanol Arznei Schwarz Gmbh Derivados de 8-etinilxantina como antagonistas de receptores de a2a selectivos.
US7994357B2 (en) * 2009-04-03 2011-08-09 Naturewise Biotech & Medicals Corporation Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
WO2020125779A1 (en) * 2018-12-21 2020-06-25 Sunshine Lake Pharma Co., Ltd. 8-substituted styryl xanthine derivatives and uses thereof
CN111333648B (zh) * 2019-04-24 2021-05-11 东莞市东阳光新药研发有限公司 8-取代的芳香环乙烯基黄嘌呤衍生物及其用途
CN110041331B (zh) * 2019-05-17 2020-08-07 广东东阳光药业有限公司 苯乙烯基黄嘌呤衍生物及其用途
CN112409360B (zh) * 2019-08-22 2022-12-23 广东东阳光药业有限公司 杂芳基乙烯基黄嘌呤衍生物及其用途
CN112300165B (zh) * 2019-11-11 2022-03-04 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111072663B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111018856B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1280424A (en) * 1969-07-30 1972-07-05 Parke Davis & Co Novel xanthine compounds and means for obtaining the same
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
GB8906792D0 (en) * 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
FR2665636B1 (fr) * 1990-08-10 1994-10-07 Adir Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer.
CA2094270C (en) * 1990-10-18 1997-01-21 Fumio Suzuki Xanthine derivatives

Also Published As

Publication number Publication date
ES2112386T3 (es) 1998-04-01
CA2093403A1 (en) 1993-10-09
JP2613352B2 (ja) 1997-05-28
GR3026233T3 (en) 1998-05-29
BR1100636A (pt) 2000-04-18
DE69316067T2 (de) 1998-07-02
HK1001835A1 (en) 1998-07-10
ATE161723T1 (de) 1998-01-15
NO931317L (no) 1993-10-11
JPH0616559A (ja) 1994-01-25
EP0565377B1 (de) 1998-01-07
DE69316067D1 (de) 1998-02-12
NO931317D0 (no) 1993-04-06
CA2093403C (en) 1999-08-10
DK0565377T3 (da) 1998-03-16
EP0565377A1 (de) 1993-10-13

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