ATE322163T1 - Substituierte cyclopentanderivate die als neuramidase-inhibitoren nuetzlich sind - Google Patents

Substituierte cyclopentanderivate die als neuramidase-inhibitoren nuetzlich sind

Info

Publication number
ATE322163T1
ATE322163T1 AT97931014T AT97931014T ATE322163T1 AT E322163 T1 ATE322163 T1 AT E322163T1 AT 97931014 T AT97931014 T AT 97931014T AT 97931014 T AT97931014 T AT 97931014T AT E322163 T1 ATE322163 T1 AT E322163T1
Authority
AT
Austria
Prior art keywords
derivatives useful
neuramidase inhibitors
cyclopentan
substituted
inhibitors
Prior art date
Application number
AT97931014T
Other languages
English (en)
Inventor
Yarlagadda S Babu
Pooran Chand
John A Montgomery
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Application granted granted Critical
Publication of ATE322163T1 publication Critical patent/ATE322163T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/02—Saturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97931014T 1996-06-14 1997-06-13 Substituierte cyclopentanderivate die als neuramidase-inhibitoren nuetzlich sind ATE322163T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1993096P 1996-06-14 1996-06-14
US4401097P 1997-05-02 1997-05-02

Publications (1)

Publication Number Publication Date
ATE322163T1 true ATE322163T1 (de) 2006-04-15

Family

ID=26692776

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931014T ATE322163T1 (de) 1996-06-14 1997-06-13 Substituierte cyclopentanderivate die als neuramidase-inhibitoren nuetzlich sind

Country Status (20)

Country Link
US (1) US6410594B1 (de)
EP (1) EP0933993B1 (de)
JP (1) JP3481255B2 (de)
KR (1) KR20000016669A (de)
CN (1) CN1227466A (de)
AT (1) ATE322163T1 (de)
AU (1) AU723360B2 (de)
BR (1) BR9711095A (de)
CA (1) CA2258217C (de)
CZ (1) CZ412898A3 (de)
DE (1) DE69735634T2 (de)
DK (1) DK0933993T3 (de)
ES (1) ES2263179T3 (de)
NO (1) NO311885B1 (de)
NZ (1) NZ333437A (de)
PL (1) PL330407A1 (de)
PT (1) PT933993E (de)
RO (1) RO121027B1 (de)
SK (1) SK171698A3 (de)
WO (1) WO1997047194A1 (de)

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AR016162A1 (es) 1997-12-17 2001-06-20 Biocryst Pharm Inc Compuestos ciclopentano y ciclopenteno sustituidos que son de utilidad como inhibidores de la neuraminidasa y composicion que los contiene.
WO1999054299A1 (en) * 1998-04-23 1999-10-28 Abbott Laboratories Pyrrolidines as inhibitors of neuraminidases
JP2002521312A (ja) * 1998-04-23 2002-07-16 アボット・ラボラトリーズ ノイラミニダーゼの阻害剤
US6455571B1 (en) * 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6503745B1 (en) * 1998-11-05 2003-01-07 Biocryst Pharmaceuticals, Inc. Cyclopentane and cyclopentene compounds and use for detecting influenza virus
IL147243A0 (en) 1999-06-28 2002-08-14 Biocryst Pharm Inc Process for preparing (-)-(1s,4r) n-protected 4-amino-2-cyclopentene-1-carboxylate esters
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
US6627396B1 (en) 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
WO2001062242A1 (en) * 2000-02-24 2001-08-30 Biocryst Pharmaceuticals, Inc. Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
WO2001080892A1 (fr) * 2000-04-25 2001-11-01 Sankyo Company, Limited Substances preventives de la grippe
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
JP4851185B2 (ja) 2003-05-16 2012-01-11 ジェレックスインターナショナル株式会社 アレルギー症状抑制剤及び空気濾過フィルター
MX2008010394A (es) * 2006-02-13 2009-01-12 Biocryst Pharm Inc Tratamientos antivirales intravenosos.
CN101420948A (zh) 2006-02-13 2009-04-29 拜奥克里斯特制药公司 静脉内抗病毒治疗
US20070244193A1 (en) * 2006-04-12 2007-10-18 Babu Yarlagadda S Intramuscular antiviral treatments
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
US20080194801A1 (en) * 2007-02-14 2008-08-14 Swanson Basil I Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
WO2011150205A2 (en) * 2010-05-27 2011-12-01 Dr. Reddy's Laboratories Ltd. Highly selective asymmetric hydroformylation of (1s,4r) or (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3- one (+) or (-)-lactam
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
CN102584637B (zh) * 2011-01-17 2014-07-09 天津药物研究院 帕拉米韦水合物晶体、制备方法、药用组合物及其用途
CN102603577A (zh) * 2011-01-19 2012-07-25 董慧珍 一种抗流感和禽流感药物的衍生物及其用途
CN102863359B (zh) * 2012-05-16 2014-05-07 常州制药厂有限公司 一种抗流感药物的合成方法
CN104402754B (zh) * 2014-11-25 2016-03-02 广东东阳光药业有限公司 作为神经氨酸酶抑制剂的化合物及其在药物中的应用
CN104387288B (zh) * 2014-11-25 2016-04-20 广东东阳光药业有限公司 作为神经氨酸酶抑制剂的化合物及其在药物中的应用
CN104496839B (zh) * 2014-12-03 2016-04-20 广东东阳光药业有限公司 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途
CN104447390B (zh) * 2014-12-03 2016-03-02 广东东阳光药业有限公司 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途
CN104496857B (zh) * 2014-12-10 2016-10-12 广东东阳光药业有限公司 作为神经氨酸酶抑制剂的化合物及其在药物中的应用
CN110128288B (zh) * 2018-02-02 2023-07-28 浙江九洲药业股份有限公司 一种氨基取代的环戊烷甲酸烷基酯衍生物的制备方法
WO2023192165A1 (en) * 2022-03-27 2023-10-05 Tranexamic Technologies, Llc Tranexamic class arginine and histidine mimics as therapeutic agents

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JP2002521312A (ja) 1998-04-23 2002-07-16 アボット・ラボラトリーズ ノイラミニダーゼの阻害剤
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Also Published As

Publication number Publication date
DE69735634D1 (de) 2006-05-18
DE69735634T2 (de) 2007-05-03
EP0933993B1 (de) 2006-04-05
NO985821D0 (no) 1998-12-11
RO121027B1 (ro) 2006-11-30
DK0933993T3 (da) 2006-08-14
JP3481255B2 (ja) 2003-12-22
US6410594B1 (en) 2002-06-25
ES2263179T3 (es) 2006-12-01
EP0933993A1 (de) 1999-08-11
KR20000016669A (ko) 2000-03-25
NO311885B1 (no) 2002-02-11
CN1227466A (zh) 1999-09-01
PL330407A1 (en) 1999-05-10
NO985821L (no) 1999-02-10
PT933993E (pt) 2006-10-31
SK171698A3 (en) 1999-10-08
AU3475097A (en) 1998-01-07
AU723360B2 (en) 2000-08-24
CZ412898A3 (cs) 1999-08-11
JP2000505088A (ja) 2000-04-25
WO1997047194A1 (en) 1997-12-18
BR9711095A (pt) 2001-07-17
CA2258217A1 (en) 1997-12-18
EP0933993A4 (de) 2004-09-08
NZ333437A (en) 2000-05-26
CA2258217C (en) 2005-08-09

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