NO327165B1 - Rekombinant mistellectin, fremgangsmate for fremstilling derav, nukleinsyre som koder for dette, vektor, vertscelle samt legemiddel og diagnostisk blanding. - Google Patents
Rekombinant mistellectin, fremgangsmate for fremstilling derav, nukleinsyre som koder for dette, vektor, vertscelle samt legemiddel og diagnostisk blanding. Download PDFInfo
- Publication number
- NO327165B1 NO327165B1 NO19976058A NO976058A NO327165B1 NO 327165 B1 NO327165 B1 NO 327165B1 NO 19976058 A NO19976058 A NO 19976058A NO 976058 A NO976058 A NO 976058A NO 327165 B1 NO327165 B1 NO 327165B1
- Authority
- NO
- Norway
- Prior art keywords
- nucleic acid
- acid molecule
- polypeptide
- host
- cell
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title claims 19
- 108020004707 nucleic acids Proteins 0.000 title claims 18
- 102000039446 nucleic acids Human genes 0.000 title claims 18
- 239000013598 vector Substances 0.000 title claims 6
- 229940079593 drug Drugs 0.000 title claims 2
- 239000003814 drug Substances 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title claims 2
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 239000000539 dimer Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 6
- 230000008827 biological function Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 241000196324 Embryophyta Species 0.000 claims 3
- 241000221012 Viscum Species 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 235000014066 European mistletoe Nutrition 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 102000004856 Lectins Human genes 0.000 claims 2
- 108090001090 Lectins Proteins 0.000 claims 2
- 235000012300 Rhipsalis cassutha Nutrition 0.000 claims 2
- 230000009144 enzymatic modification Effects 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 230000002637 immunotoxin Effects 0.000 claims 2
- 229940051026 immunotoxin Drugs 0.000 claims 2
- 239000002596 immunotoxin Substances 0.000 claims 2
- 231100000608 immunotoxin Toxicity 0.000 claims 2
- 239000002523 lectin Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000256248 Spodoptera Species 0.000 claims 1
- 241000256251 Spodoptera frugiperda Species 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/42—Lectins, e.g. concanavalin, phytohaemagglutinin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95109949A EP0751221B1 (de) | 1995-06-26 | 1995-06-26 | Rekombinantes Mistellektin (rML) |
| PCT/EP1996/002773 WO1997001636A2 (de) | 1995-06-26 | 1996-06-25 | REKOMBINANTES MISTELLEKTIN (rML) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO976058D0 NO976058D0 (no) | 1997-12-23 |
| NO976058L NO976058L (no) | 1998-02-03 |
| NO327165B1 true NO327165B1 (no) | 2009-05-04 |
Family
ID=8219389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19976058A NO327165B1 (no) | 1995-06-26 | 1997-12-23 | Rekombinant mistellectin, fremgangsmate for fremstilling derav, nukleinsyre som koder for dette, vektor, vertscelle samt legemiddel og diagnostisk blanding. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6271368B1 (ko) |
| EP (3) | EP0884388A1 (ko) |
| JP (2) | JP3291548B2 (ko) |
| KR (1) | KR100292918B1 (ko) |
| CN (1) | CN1160457C (ko) |
| AR (1) | AR003961A1 (ko) |
| AT (1) | ATE170922T1 (ko) |
| AU (1) | AU719297B2 (ko) |
| BR (1) | BR9609223A (ko) |
| CA (1) | CA2225924C (ko) |
| CZ (1) | CZ292689B6 (ko) |
| DE (1) | DE59503524D1 (ko) |
| DK (1) | DK0751221T3 (ko) |
| ES (1) | ES2124470T3 (ko) |
| HU (1) | HU225738B1 (ko) |
| NO (1) | NO327165B1 (ko) |
| PL (1) | PL193281B1 (ko) |
| RU (1) | RU2241750C2 (ko) |
| SK (1) | SK173197A3 (ko) |
| WO (1) | WO1997001636A2 (ko) |
| ZA (1) | ZA965361B (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1012256T3 (da) * | 1997-01-02 | 2004-07-12 | Viscum Ag | Rekombinante fusionsproteiner på basis af ribosom-inaktiverende proteiner fra misteltenen Viscum album |
| CN1104438C (zh) * | 1997-06-02 | 2003-04-02 | 山东医科大学附属医院 | 槲寄生提取物及其用途 |
| DE19804210A1 (de) * | 1998-02-03 | 1999-08-12 | Biosyn Arzneimittel Gmbh | Rekombinante Mistellektine |
| KR20010011330A (ko) * | 1999-07-27 | 2001-02-15 | 김종배 | 한국산 겨우살이 추출물과 이로부터 분리한 단백질 및 상기 단백질에서 분리한 렉틴 |
| DE10044027A1 (de) * | 2000-09-06 | 2002-03-14 | Viscum Ag | Rekombinant erzeugtes Mistellektin (ML III) |
| NZ526202A (en) * | 2000-11-14 | 2005-08-26 | Ian Pryme | Orally ingestible preparation of mistletoe lectins, ML-I, ML-II and ML-III and methods fro treating cancer and autoimmune diseases |
| DE60220068T2 (de) | 2001-07-09 | 2008-01-24 | University Of Copenhagen | Verfahren und ableger für die massenvermehrung von pflanzenparasiten |
| DE10149030A1 (de) | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| ATE362106T1 (de) * | 2001-12-21 | 2007-06-15 | Viscum Ag | Verfahren zur bestimmung der responsivität eines individuums für mistellektin |
| DE102011003478A1 (de) * | 2011-02-01 | 2012-08-02 | Cytavis Biopharma Gmbh | Antivirales Mittel enthaltend rekombinante Mistellektine |
| EP2508195A1 (de) * | 2011-04-06 | 2012-10-10 | Cytavis BioPharma GmbH | Arzneimittel enthaltend rekombinante Mistellektine zur Behandlung des malignen Melanoms |
| EP2723374B1 (de) * | 2011-06-27 | 2017-09-06 | Melema Pharma GmbH | Rekombinantes mistellektin und dessen verwendung als adjuvans |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| EP3205348A1 (de) | 2016-02-15 | 2017-08-16 | Melema Pharma GmbH | Arzneimittel enthaltend rekombinante mistellektine zur behandlung von hirntumoren |
| CN106166223A (zh) * | 2016-09-17 | 2016-11-30 | 四川易创生物科技有限公司 | 一种治疗肺肾阴亏、潮热盗汗的中药组合物及其制备方法 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN115025207B (zh) * | 2022-06-23 | 2023-02-07 | 黑龙江中医药大学 | 一种用于治疗类风湿性关节炎的药物及其制备方法 |
| CN117924453B (zh) * | 2024-03-19 | 2024-08-06 | 广东现代汉方科技有限公司 | 一种甘露糖特异性凝集素重组植物蛋白的制备方法及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127532A (en) * | 1989-09-12 | 2000-10-03 | Board Of Trustees Operating Michigan State University | Lectin cDNA and transgenic plants derived therefrom |
| US5407454A (en) * | 1989-11-07 | 1995-04-18 | Pioneer Hi-Bred International, Inc. | Larvicidal lectins and plant insect resistance based thereon |
| DE4221836A1 (de) | 1992-07-03 | 1994-01-05 | Gabius Hans Joachim Prof Dr | Das biochemisch aufgereinigte Mistel-Lektin (ML-1) als therapeutisch anwendbarer Immunmodulator |
| DE4341476A1 (de) * | 1993-12-02 | 1995-06-08 | Uwe Dr Pfueller | Mittel zur Untersuchung und Beeinflussung zellulärer Veränderungen auf Lektinbasis |
-
1995
- 1995-06-26 EP EP98105660A patent/EP0884388A1/de not_active Withdrawn
- 1995-06-26 AT AT95109949T patent/ATE170922T1/de active
- 1995-06-26 EP EP95109949A patent/EP0751221B1/de not_active Expired - Lifetime
- 1995-06-26 DK DK95109949T patent/DK0751221T3/da active
- 1995-06-26 DE DE59503524T patent/DE59503524D1/de not_active Expired - Lifetime
- 1995-06-26 ES ES95109949T patent/ES2124470T3/es not_active Expired - Lifetime
-
1996
- 1996-05-31 CN CNB961960256A patent/CN1160457C/zh not_active Expired - Fee Related
- 1996-06-25 PL PL324209A patent/PL193281B1/pl not_active IP Right Cessation
- 1996-06-25 US US08/776,059 patent/US6271368B1/en not_active Expired - Lifetime
- 1996-06-25 JP JP50416997A patent/JP3291548B2/ja not_active Expired - Fee Related
- 1996-06-25 AU AU64163/96A patent/AU719297B2/en not_active Ceased
- 1996-06-25 RU RU98101194/13A patent/RU2241750C2/ru not_active IP Right Cessation
- 1996-06-25 ZA ZA9605361A patent/ZA965361B/xx unknown
- 1996-06-25 CZ CZ19974049A patent/CZ292689B6/cs not_active IP Right Cessation
- 1996-06-25 WO PCT/EP1996/002773 patent/WO1997001636A2/de active IP Right Grant
- 1996-06-25 EP EP96923926A patent/EP0835312A2/de not_active Withdrawn
- 1996-06-25 CA CA002225924A patent/CA2225924C/en not_active Expired - Fee Related
- 1996-06-25 HU HU9900316A patent/HU225738B1/hu not_active IP Right Cessation
- 1996-06-25 BR BR9609223A patent/BR9609223A/pt not_active Application Discontinuation
- 1996-06-25 KR KR1019970709890A patent/KR100292918B1/ko not_active IP Right Cessation
- 1996-06-25 SK SK1731-97A patent/SK173197A3/sk unknown
- 1996-06-26 AR ARP960103316A patent/AR003961A1/es unknown
-
1997
- 1997-12-23 NO NO19976058A patent/NO327165B1/no not_active IP Right Cessation
-
2001
- 2001-12-28 JP JP2001401821A patent/JP2002300890A/ja not_active Withdrawn
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| MM1K | Lapsed by not paying the annual fees |