KR900014428A - 신규폴리펩타이드 및 그 제조방법 - Google Patents

신규폴리펩타이드 및 그 제조방법 Download PDF

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KR900014428A
KR900014428A KR1019900003202A KR900003202A KR900014428A KR 900014428 A KR900014428 A KR 900014428A KR 1019900003202 A KR1019900003202 A KR 1019900003202A KR 900003202 A KR900003202 A KR 900003202A KR 900014428 A KR900014428 A KR 900014428A
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polypeptide
amino acid
acid sequence
following amino
molecule
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KR1019900003202A
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KR0132425B1 (ko
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가즈오 나까하마
요시히꼬 가이쇼
고지 요시무라
레이꼬 사사다
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우메모또 요시마사
다께다야꾸힝 고오교 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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Abstract

내용 없음

Description

신규폴리펩타이드 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예1 에서 얻어진 플라스미드 pUNK5 내의 폴리펩타이드(Ⅰ)cDNA를 포함하는 DNA의 제한 효소 지도이며, 뉴클레오티드 서열 및 그로부터 해독된 아미노산서열을 나타내며,
제3도는 실시예1에서 얻어진 본 발명의 폴리펩타이드(Ⅰ)의 아미노산서열(윗줄)과 사람 βNGF의 아미노산서열(아랫줄)과의 비교를 나타낸다.

Claims (10)

  1. 분자내에 하기 아미노산 서열(Ⅱ)를 포함하는 폴리펩타이드(Ⅰ).
  2. 제1항에 있어서, 하기 아미노산 서열(Ⅱ')을 갖는 폴리펩타이드.
  3. 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드 (Ⅰ)에 대해 코오딩하는 DNA.
  4. 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA를 함유하는 벡터.
  5. 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA을 함유하는 벡터에 의해 형질전환된 형질 전환제.
  6. 제5항에 따른 에스케리키아 콜라이 BL21(DE3)/pENGFT102(FFRM BP-2420).
  7. 제5항에 따른 사카로마이세스 세레비시애 TB39ρ/pANT 341T(FERM BP-2530).
  8. 제5항에 따른 에스케리키아 콜라이 BL21(DE3)/pLyS, pENGFT102(FERM BP-2529).
  9. 제5항에 따른 L-H14-1(FERM BP-2754).
  10. 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA를 함유하는 벡터에 의해 형질전환된 형질 전환체를 배지 내에서 배양하고, 폴리펩타이드를 축적하고, 폴리펩타이드를 수집하는 것으로 구성되는, 분자내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900003202A 1989-03-10 1990-03-10 신규 폴리펩타이드 및 그 제조방법 KR0132425B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP1-58983 1989-03-10
JP5898389 1989-03-10
JP12771089 1989-05-19
JP127710/1989 1989-05-19
JP19365489 1989-07-26
JP193654/1989 1989-07-26
JP263613/1989 1989-10-09
JP26361389 1989-10-09

Publications (2)

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KR900014428A true KR900014428A (ko) 1990-10-23
KR0132425B1 KR0132425B1 (ko) 1998-04-14

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KR1019900003202A KR0132425B1 (ko) 1989-03-10 1990-03-10 신규 폴리펩타이드 및 그 제조방법

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US (1) US6709837B1 (ko)
EP (1) EP0386752B1 (ko)
JP (1) JPH0780904B2 (ko)
KR (1) KR0132425B1 (ko)
AT (1) ATE111521T1 (ko)
CA (1) CA2011833C (ko)
DE (1) DE69012377T2 (ko)
DK (1) DK0386752T3 (ko)
ES (1) ES2059854T3 (ko)
HK (1) HK34896A (ko)
IE (1) IE65361B1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656435A (en) * 1989-08-28 1997-08-12 Takeda Chemical Industries, Ltd. Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US6933276B1 (en) 1989-08-30 2005-08-23 Regeneron Pharmaceuticals, Inc. Methods of treating peripheral neuropathies using neurotrophin-3
GR1000980B (el) * 1989-08-30 1993-03-31 Max Planck Gesellschaft Νευροτροφινη-3,ενας νεος neυροτροφικος παραγοντας που σχετιζεται με τον παραγοντα αναπτυξης νευρων και τον νευροτροφικο παραγοντα που προερχεται απο τον εγκεφαλο.
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
ATE154389T1 (de) * 1991-02-18 1997-06-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von menschlichem ngf-2
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
DE69330809T2 (de) * 1992-06-08 2002-05-16 Takeda Chemical Industries Ltd Therapeutisches Agens für Neutropenie
AU5684594A (en) * 1992-12-02 1994-06-22 Novo Nordisk A/S Novel human amyloid protein precursor homologue and kunitz-type inhibitors
JP2732005B2 (ja) * 1992-12-14 1998-03-25 眞一 富永 ヒトｓｔ２をコードするｄｎａ、該ｄｎａの発現産物、該ｄｎａを発現させることによる発現産物の製造方法
JPH07246040A (ja) * 1993-07-06 1995-09-26 Takeda Chem Ind Ltd ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物
US5877016A (en) * 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5681931A (en) * 1995-03-15 1997-10-28 Becton, Dickinson And Company Human restrictin
US5864018A (en) * 1996-04-16 1999-01-26 Schering Aktiengesellschaft Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor
EP0942964A2 (en) * 1996-11-22 1999-09-22 Human Genome Sciences, Inc. Thermostable polymerases having altered fidelity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor

Also Published As

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ES2059854T3 (es) 1994-11-16
ATE111521T1 (de) 1994-09-15
IE900785L (en) 1990-09-10
DE69012377T2 (de) 1995-05-04
KR0132425B1 (ko) 1998-04-14
JPH0780904B2 (ja) 1995-08-30
HK34896A (en) 1996-03-08
DE69012377D1 (de) 1994-10-20
EP0386752B1 (en) 1994-09-14
US6709837B1 (en) 2004-03-23
DK0386752T3 (da) 1994-12-05
CA2011833C (en) 2002-11-05
CA2011833A1 (en) 1990-09-10
JPH03204897A (ja) 1991-09-06
EP0386752A1 (en) 1990-09-12
IE65361B1 (en) 1995-10-18

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