KR900014428A - 신규폴리펩타이드 및 그 제조방법 - Google Patents
신규폴리펩타이드 및 그 제조방법 Download PDFInfo
- Publication number
- KR900014428A KR900014428A KR1019900003202A KR900003202A KR900014428A KR 900014428 A KR900014428 A KR 900014428A KR 1019900003202 A KR1019900003202 A KR 1019900003202A KR 900003202 A KR900003202 A KR 900003202A KR 900014428 A KR900014428 A KR 900014428A
- Authority
- KR
- South Korea
- Prior art keywords
- polypeptide
- amino acid
- acid sequence
- following amino
- molecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예1 에서 얻어진 플라스미드 pUNK5 내의 폴리펩타이드(Ⅰ)cDNA를 포함하는 DNA의 제한 효소 지도이며, 뉴클레오티드 서열 및 그로부터 해독된 아미노산서열을 나타내며,
제3도는 실시예1에서 얻어진 본 발명의 폴리펩타이드(Ⅰ)의 아미노산서열(윗줄)과 사람 βNGF의 아미노산서열(아랫줄)과의 비교를 나타낸다.
Claims (10)
- 분자내에 하기 아미노산 서열(Ⅱ)를 포함하는 폴리펩타이드(Ⅰ).
- 제1항에 있어서, 하기 아미노산 서열(Ⅱ')을 갖는 폴리펩타이드.
- 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드 (Ⅰ)에 대해 코오딩하는 DNA.
- 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA를 함유하는 벡터.
- 분자 내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA을 함유하는 벡터에 의해 형질전환된 형질 전환제.
- 제5항에 따른 에스케리키아 콜라이 BL21(DE3)/pENGFT102(FFRM BP-2420).
- 제5항에 따른 사카로마이세스 세레비시애 TB39ρ/pANT 341T(FERM BP-2530).
- 제5항에 따른 에스케리키아 콜라이 BL21(DE3)/pLyS, pENGFT102(FERM BP-2529).
- 제5항에 따른 L-H14-1(FERM BP-2754).
- 폴리펩타이드(Ⅰ)에 대해 코오딩하는 DNA를 함유하는 벡터에 의해 형질전환된 형질 전환체를 배지 내에서 배양하고, 폴리펩타이드를 축적하고, 폴리펩타이드를 수집하는 것으로 구성되는, 분자내에 하기 아미노산 서열(Ⅱ)을 포함하는 폴리펩타이드(Ⅰ)의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5898389 | 1989-03-10 | ||
JP127710/1989 | 1989-05-19 | ||
JP12771089 | 1989-05-19 | ||
JP193654/1989 | 1989-07-26 | ||
JP19365489 | 1989-07-26 | ||
JP26361389 | 1989-10-09 | ||
JP263613/1989 | 1989-10-09 | ||
JP1-58983 | 1989-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900014428A true KR900014428A (ko) | 1990-10-23 |
KR0132425B1 KR0132425B1 (ko) | 1998-04-14 |
Family
ID=27463714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900003202A KR0132425B1 (ko) | 1989-03-10 | 1990-03-10 | 신규 폴리펩타이드 및 그 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6709837B1 (ko) |
EP (1) | EP0386752B1 (ko) |
JP (1) | JPH0780904B2 (ko) |
KR (1) | KR0132425B1 (ko) |
AT (1) | ATE111521T1 (ko) |
CA (1) | CA2011833C (ko) |
DE (1) | DE69012377T2 (ko) |
DK (1) | DK0386752T3 (ko) |
ES (1) | ES2059854T3 (ko) |
HK (1) | HK34896A (ko) |
IE (1) | IE65361B1 (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656435A (en) * | 1989-08-28 | 1997-08-12 | Takeda Chemical Industries, Ltd. | Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof |
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US6933276B1 (en) | 1989-08-30 | 2005-08-23 | Regeneron Pharmaceuticals, Inc. | Methods of treating peripheral neuropathies using neurotrophin-3 |
GR1000980B (el) | 1989-08-30 | 1993-03-31 | Max Planck Gesellschaft | Νευροτροφινη-3,ενας νεος neυροτροφικος παραγοντας που σχετιζεται με τον παραγοντα αναπτυξης νευρων και τον νευροτροφικο παραγοντα που προερχεται απο τον εγκεφαλο. |
US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
US6511823B1 (en) * | 1990-08-20 | 2003-01-28 | American Cyanamid Corporation | Heparin binding neurotrophic factor gene sequence |
ATE154389T1 (de) * | 1991-02-18 | 1997-06-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von menschlichem ngf-2 |
US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
EP0573904B1 (en) * | 1992-06-08 | 2001-09-26 | Takeda Chemical Industries, Ltd. | Therapeutic agent for neutropenia |
WO1994012637A2 (en) * | 1992-12-02 | 1994-06-09 | Zymogenetics, Inc. | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
JP2732005B2 (ja) * | 1992-12-14 | 1998-03-25 | 眞一 富永 | ヒトst2をコードするdna、該dnaの発現産物、該dnaを発現させることによる発現産物の製造方法 |
JPH07246040A (ja) * | 1993-07-06 | 1995-09-26 | Takeda Chem Ind Ltd | ニューロトロフィン−3遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物 |
US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
US5681931A (en) * | 1995-03-15 | 1997-10-28 | Becton, Dickinson And Company | Human restrictin |
US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
WO1998022575A2 (en) * | 1996-11-22 | 1998-05-28 | Human Genome Sciences, Inc. | Nucleotide sequence of escherichia coli pathogenicity islands |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161152C (da) | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
-
1990
- 1990-03-05 US US07/488,696 patent/US6709837B1/en not_active Expired - Fee Related
- 1990-03-06 IE IE78590A patent/IE65361B1/en not_active IP Right Cessation
- 1990-03-08 AT AT90104419T patent/ATE111521T1/de not_active IP Right Cessation
- 1990-03-08 JP JP2057751A patent/JPH0780904B2/ja not_active Expired - Lifetime
- 1990-03-08 EP EP90104419A patent/EP0386752B1/en not_active Expired - Lifetime
- 1990-03-08 ES ES90104419T patent/ES2059854T3/es not_active Expired - Lifetime
- 1990-03-08 DE DE69012377T patent/DE69012377T2/de not_active Expired - Lifetime
- 1990-03-08 DK DK90104419.8T patent/DK0386752T3/da active
- 1990-03-09 CA CA002011833A patent/CA2011833C/en not_active Expired - Lifetime
- 1990-03-10 KR KR1019900003202A patent/KR0132425B1/ko not_active IP Right Cessation
-
1996
- 1996-02-29 HK HK34896A patent/HK34896A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH03204897A (ja) | 1991-09-06 |
US6709837B1 (en) | 2004-03-23 |
CA2011833A1 (en) | 1990-09-10 |
KR0132425B1 (ko) | 1998-04-14 |
ES2059854T3 (es) | 1994-11-16 |
DE69012377T2 (de) | 1995-05-04 |
EP0386752A1 (en) | 1990-09-12 |
IE65361B1 (en) | 1995-10-18 |
ATE111521T1 (de) | 1994-09-15 |
CA2011833C (en) | 2002-11-05 |
DK0386752T3 (da) | 1994-12-05 |
HK34896A (en) | 1996-03-08 |
IE900785L (en) | 1990-09-10 |
JPH0780904B2 (ja) | 1995-08-30 |
DE69012377D1 (de) | 1994-10-20 |
EP0386752B1 (en) | 1994-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR900014428A (ko) | 신규폴리펩타이드 및 그 제조방법 | |
KR880701288A (ko) | M-csf의 제법 | |
US5464939A (en) | Highly purified protein, production and use thereof | |
KR890012000A (ko) | 인간 b세포 자극인자-2에 대한 수용체 단백질 | |
KR870000427A (ko) | 하이브리드 인터페론의 제조방법 | |
KR920701451A (ko) | 인체혈청알부민의 n-말단 단편을 함유하는 융합 단백질 | |
AU704515C (en) | Novel protein and process for producing the same | |
IT1153265B (it) | Polipeptidi contenenti la sequenza degli amminoacidi dell'interferone umano immune (interferone umano gamma), relativi veicoli di espressione, loro procedimento di preparazione, composizioni farmaceutiche contenenti tali polipeptidi | |
PT81590B (pt) | Metodo para a producao de um clone de cdna humanoque exprime eritropoietina biologicamente activa | |
KR920702417A (ko) | Tcf-ii의 아미노산 배열을 코드하는 dna를 함유한 플라스미드, 형질전환세포, 및 이것을 사용하여 생리 활성물질을 생산하는 방법 | |
KR910000796A (ko) | 미니-프로인슐린, 이의 제조방법 및 용도 | |
KR910006483A (ko) | 재조합 아프로티닌 변이체, 균질하게 프로세싱된 아프로티닌 변이체의 미생물을 이용한 유전공학적 제조 방법 및 그의 치료 용도 | |
ES2088911T3 (es) | Gen de la proteasa i de achromobacter y el producto de este gen. | |
EP0276778A3 (en) | High level expression in e. coli of soluble mature hil-1beta and derivatives with altered biological activity | |
KR900700615A (ko) | 사람 호중구 화학주성 인자 폴리펩티드의 제조방법 | |
CN105218659B (zh) | 人骨形成蛋白2成熟肽及其表达 | |
KR880005264A (ko) | 사카로미세스 세레비시아에에서 재조합 인간 psti제법 | |
ATE119938T1 (de) | Produktion von menschlichen nervenwachstumsfaktoren. | |
KR100729830B1 (ko) | 페너트라틴을 이용하여 단백질의 세포투과를 증진시키는대장균용발현벡터 | |
HUP9800520A2 (hu) | Génexpresszió emlős sejtekben | |
Dabrowska et al. | Dimerization of the polypeptide chains of skeletal muscle tropomyosin | |
KR890013177A (ko) | 신규폴리펩티드 및 그것을 코우드하는 dna | |
RU96104560A (ru) | Способ получения эритропоэтина человека и способ получения фармацевтической композиции | |
GENES | Medium for electrophoresis | |
Read et al. | Two‐dimensional gel resolution of polypeptides specific for autotrophic growth in Thiobacillus versutus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20101124 Year of fee payment: 14 |
|
LAPS | Lapse due to unpaid annual fee |