NO326883B1 - Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere - Google Patents

Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere Download PDF

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Publication number
NO326883B1
NO326883B1 NO20034988A NO20034988A NO326883B1 NO 326883 B1 NO326883 B1 NO 326883B1 NO 20034988 A NO20034988 A NO 20034988A NO 20034988 A NO20034988 A NO 20034988A NO 326883 B1 NO326883 B1 NO 326883B1
Authority
NO
Norway
Prior art keywords
het
4alkyl
alkyl
aryl
optionally
Prior art date
Application number
NO20034988A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034988D0 (no
Inventor
Wim Gaston Verschueren
Sandrine Marie Helene Vendeville
Marie-Pierre T M M G D Bethune
Herman Augustinus De Kock
Abdellah Tahri
Dominique Louis Nestor Ghislain Surleraux
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20034988D0 publication Critical patent/NO20034988D0/no
Publication of NO326883B1 publication Critical patent/NO326883B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20034988A 2001-05-11 2003-11-10 Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere NO326883B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01201732 2001-05-11
PCT/EP2002/005212 WO2002092595A1 (en) 2001-05-11 2002-05-10 Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
NO20034988D0 NO20034988D0 (no) 2003-11-10
NO326883B1 true NO326883B1 (no) 2009-03-09

Family

ID=8180286

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034988A NO326883B1 (no) 2001-05-11 2003-11-10 Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere

Country Status (32)

Country Link
US (2) US7622490B2 (ja)
EP (1) EP1387842B1 (ja)
JP (1) JP4467889B2 (ja)
KR (1) KR100878853B1 (ja)
CN (1) CN100549007C (ja)
AP (1) AP1652A (ja)
AR (1) AR035970A1 (ja)
AT (1) ATE429431T1 (ja)
AU (1) AU2002310818B2 (ja)
BG (1) BG66350B1 (ja)
BR (1) BR0209594A (ja)
CA (1) CA2444895C (ja)
CY (1) CY1109247T1 (ja)
CZ (1) CZ304524B6 (ja)
DE (1) DE60232067D1 (ja)
DK (1) DK1387842T3 (ja)
EA (1) EA009590B1 (ja)
EE (1) EE05307B1 (ja)
ES (1) ES2325809T3 (ja)
HK (1) HK1062912A1 (ja)
HR (1) HRP20031026B1 (ja)
HU (1) HUP0400438A3 (ja)
IL (1) IL158093A0 (ja)
MX (1) MXPA03010258A (ja)
NO (1) NO326883B1 (ja)
NZ (1) NZ529250A (ja)
OA (1) OA13134A (ja)
PL (1) PL209029B1 (ja)
PT (1) PT1387842E (ja)
SK (1) SK287952B6 (ja)
WO (1) WO2002092595A1 (ja)
ZA (1) ZA200307799B (ja)

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ATE329579T1 (de) 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20040009890A1 (en) 2002-01-07 2004-01-15 Erickson John W. Broad spectrum inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
KR101090102B1 (ko) * 2003-09-30 2011-12-07 티보텍 파마슈티컬즈 벤조옥사졸 설폰아미드 화합물 및 그의 중간체를 제조하는방법
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
SI1725566T1 (sl) 2003-12-23 2009-12-31 Tibotec Pharm Ltd Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
EP1750696B1 (en) * 2004-05-07 2013-06-26 Sequoia Pharmaceuticals Inc RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
RU2421459C2 (ru) 2005-02-25 2011-06-20 Тиботек Фармасьютикалз Лтд. Синтез предшественника ингибитора протеазы
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US20120220520A1 (en) * 2006-10-17 2012-08-30 Van T Klooster Gerben Albert Eleutherius Bioavailable combinations for hcv treatment
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

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ES2093073T3 (es) 1990-03-09 1996-12-16 Milliken Res Corp Materiales organicos que tienen restos poli(oxialquilenos) enlazados por un grupo sulfonamido y su preparacion.
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
JP4091653B2 (ja) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー レトロウイルスプロテアーゼ阻害剤として有用なｎ−（アルカノイルアミノ−２−ヒドロキシプロピル）スルホンアミド
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
EP0715618B1 (en) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
HU222355B1 (hu) 1993-10-01 2003-06-28 Astra Aktiebolag Eljárás és berendezés finom gyógyszerhatóanyag-porok kezelésére és feldolgozására
CA2210889C (en) 1995-01-20 2007-08-28 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
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JP2000515488A (ja) * 1995-11-15 2000-11-21 ジー．ディー．サール アンド カンパニー 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤
TR199801225T2 (xx) 1996-05-20 1998-11-23 Janssen Pharmaceutica N.V. Geli�tirilmi� biyolojik kullan�l�rl��a sahip antifungal bile�imler.
RU2218153C2 (ru) 1997-03-26 2003-12-10 Жансен Фармасетика Н.В. Драже, имеющее ядро, покрытое противогрибковым средством и полимером
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EA007383B1 (ru) * 2001-04-09 2006-10-27 Тиботек Фармасьютикалз Лтд. 2-(замещенный амино)бензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра

Also Published As

Publication number Publication date
IL158093A0 (en) 2004-03-28
JP2004534757A (ja) 2004-11-18
CY1109247T1 (el) 2014-07-02
PL366780A1 (en) 2005-02-07
AP1652A (en) 2006-08-11
HRP20031026A2 (en) 2005-10-31
PT1387842E (pt) 2009-07-20
US7622490B2 (en) 2009-11-24
EP1387842A1 (en) 2004-02-11
EE05307B1 (et) 2010-06-15
SK287952B6 (sk) 2012-06-04
AP2003002904A0 (en) 2003-12-31
HUP0400438A3 (en) 2007-08-28
US20100029632A1 (en) 2010-02-04
EP1387842B1 (en) 2009-04-22
ZA200307799B (en) 2005-03-30
WO2002092595A1 (en) 2002-11-21
PL209029B1 (pl) 2011-07-29
ES2325809T3 (es) 2009-09-18
SK14902003A3 (sk) 2004-07-07
BR0209594A (pt) 2004-03-30
BG66350B1 (bg) 2013-08-30
CN1507446A (zh) 2004-06-23
AR035970A1 (es) 2004-07-28
EA009590B1 (ru) 2008-02-28
HK1062912A1 (en) 2004-12-03
EA200301234A1 (ru) 2004-04-29
HUP0400438A2 (hu) 2004-08-30
AU2002310818B2 (en) 2007-12-13
DE60232067D1 (de) 2009-06-04
JP4467889B2 (ja) 2010-05-26
CZ304524B6 (cs) 2014-06-18
KR20040022417A (ko) 2004-03-12
MXPA03010258A (es) 2005-03-07
CA2444895A1 (en) 2002-11-21
KR100878853B1 (ko) 2009-01-15
US20040106661A1 (en) 2004-06-03
NO20034988D0 (no) 2003-11-10
HRP20031026B1 (en) 2012-07-31
DK1387842T3 (da) 2009-08-10
ATE429431T1 (de) 2009-05-15
EE200300547A (et) 2004-02-16
CA2444895C (en) 2011-02-15
OA13134A (en) 2006-12-13
US7863306B2 (en) 2011-01-04
CZ20033290A3 (cs) 2004-05-12
BG108309A (bg) 2004-12-30
NZ529250A (en) 2005-05-27
CN100549007C (zh) 2009-10-14

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