NO324426B1 - 2-aminokarbonyl-9H-purinderivater, samt anvendelse og fremgangsmate for fremstilling derav, og farmasoytisk sammensetning - Google Patents

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Publication number

NO324426B1

NO324426B1 NO20025821A NO20025821A NO324426B1 NO 324426 B1 NO324426 B1 NO 324426B1 NO 20025821 A NO20025821 A NO 20025821A NO 20025821 A NO20025821 A NO 20025821A NO 324426 B1 NO324426 B1 NO 324426B1

Authority

NO

Norway

Prior art keywords

formula

compound according

alkyl

compound

optionally substituted

Prior art date

2000-06-06

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• 238000000034 method Methods 0.000 title claims abstract description 66
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• BMHHQPYFORGXQA-UHFFFAOYSA-N 7h-purine-2-carboxamide Chemical class NC(=O)C1=NC=C2N=CNC2=N1 BMHHQPYFORGXQA-UHFFFAOYSA-N 0.000 title description 3
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• 238000006243 chemical reaction Methods 0.000 claims description 61
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 48
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 38
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 36
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 31
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• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 30
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 28
• 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims description 28
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 25
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• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 6
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• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
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• WXTOFTCCIXLSKC-UHFFFAOYSA-N 1-(2-aminoethyl)-3-(1-pyridin-2-ylpiperidin-4-yl)urea;dihydrochloride Chemical compound Cl.Cl.C1CC(NC(=O)NCCN)CCN1C1=CC=CC=N1 WXTOFTCCIXLSKC-UHFFFAOYSA-N 0.000 claims description 3
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