NO323354B1 - Nye spiroheterocykliske forbindelser nyttige som inhibitorer av cystein proteaser samt anvendelse og fremstilling derav og farmasoytisk preparat. - Google Patents

Nye spiroheterocykliske forbindelser nyttige som inhibitorer av cystein proteaser samt anvendelse og fremstilling derav og farmasoytisk preparat. Download PDF

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Publication number
NO323354B1
NO323354B1 NO20021207A NO20021207A NO323354B1 NO 323354 B1 NO323354 B1 NO 323354B1 NO 20021207 A NO20021207 A NO 20021207A NO 20021207 A NO20021207 A NO 20021207A NO 323354 B1 NO323354 B1 NO 323354B1
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Norway
Prior art keywords
cyano
ylcarbamoyl
carboxylic acid
amide
ethyl
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Application number
NO20021207A
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English (en)
Norwegian (no)
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NO20021207L (no
NO20021207D0 (no
Inventor
Eugene Richard Hickey
Sanxing Sun
Michel Jose Emmanuel
Leah Lynn Frye
Weimin Liu
Tina Marie Morwick
Denice Mary Spero
David S Thomson
Yancey David Ward
Erick Richard Roush Young
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Boehringer Ingelheim Pharma
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Publication of NO20021207L publication Critical patent/NO20021207L/no
Publication of NO20021207D0 publication Critical patent/NO20021207D0/no
Publication of NO323354B1 publication Critical patent/NO323354B1/no

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
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NO20021207A 1999-09-13 2002-03-12 Nye spiroheterocykliske forbindelser nyttige som inhibitorer av cystein proteaser samt anvendelse og fremstilling derav og farmasoytisk preparat. NO323354B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15373899P 1999-09-13 1999-09-13
US22290000P 2000-08-03 2000-08-03
PCT/US2000/023584 WO2001019816A1 (fr) 1999-09-13 2000-08-28 Composes spiroheterocycliques utiles comme inhibiteurs reversibles de cysteine protease

Publications (3)

Publication Number Publication Date
NO20021207L NO20021207L (no) 2002-03-12
NO20021207D0 NO20021207D0 (no) 2002-03-12
NO323354B1 true NO323354B1 (no) 2007-04-10

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NO20021207A NO323354B1 (no) 1999-09-13 2002-03-12 Nye spiroheterocykliske forbindelser nyttige som inhibitorer av cystein proteaser samt anvendelse og fremstilling derav og farmasoytisk preparat.

Country Status (30)

Country Link
EP (1) EP1218372B1 (fr)
JP (1) JP2003529546A (fr)
KR (1) KR20030024651A (fr)
CN (1) CN100410250C (fr)
AR (1) AR032136A1 (fr)
AT (1) ATE244235T1 (fr)
AU (1) AU782246B2 (fr)
BG (1) BG106483A (fr)
BR (1) BR0013966A (fr)
CA (1) CA2385130C (fr)
CZ (1) CZ2002844A3 (fr)
DE (1) DE60003702T2 (fr)
DK (1) DK1218372T3 (fr)
EE (1) EE200200132A (fr)
ES (1) ES2199856T3 (fr)
HK (1) HK1048807A1 (fr)
HR (1) HRP20020221A2 (fr)
HU (1) HUP0302380A2 (fr)
IL (2) IL148184A0 (fr)
MY (1) MY122696A (fr)
NO (1) NO323354B1 (fr)
NZ (1) NZ518255A (fr)
PL (1) PL364045A1 (fr)
PT (1) PT1218372E (fr)
RU (1) RU2255937C2 (fr)
SA (1) SA00210456B1 (fr)
SK (1) SK286463B6 (fr)
TW (1) TWI230159B (fr)
WO (1) WO2001019816A1 (fr)
YU (1) YU17402A (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1178958B1 (fr) 1999-03-15 2004-02-18 Axys Pharmaceuticals, Inc. N-cyanomethyl amides utilises en qualite d'inhibiteurs de proteases
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
MXPA04002282A (es) 2001-09-14 2005-03-07 Axis Pharmaceutical Inc Nuevos compuestos y preparaciones como inhibidores de la catepsina.
US6936606B2 (en) 2001-10-02 2005-08-30 Boehringer Ingelheim Pharmaceuticals, Inc. Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases
US6841571B2 (en) 2001-10-29 2005-01-11 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases
RU2004117877A (ru) 2001-11-14 2006-01-10 Авентис Фармасьютикалз Инк. (Us) Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s
WO2003075853A2 (fr) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Derives cycliques servant de modulateurs de l'activite du recepteur de la chimiokine
US7101880B2 (en) 2002-06-24 2006-09-05 Schering Aktiengesellschaft Peptidic compounds as cysteine protease inhibitors
HU230612B1 (hu) 2002-11-27 2017-04-28 Incyte Corporation Kemokin receptorokat módosító hatású 3-aminopirrolidin-származékok
WO2004052921A1 (fr) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Derives de cyanomethyle en tant qu'inhibiteurs de la protease a cysteine
US7109243B2 (en) 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
US7384970B2 (en) 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
JP2006526657A (ja) 2003-06-04 2006-11-24 アクシス ファーマシューティカルズ システインプロテアーゼ阻害剤としてのアミジノ化合物
US7173051B2 (en) 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
KR20060079143A (ko) * 2003-09-18 2006-07-05 액시스 파마슈티컬스 인코포레이티드 시스테인 프로테아제 억제제로서의 할로알킬 함유 화합물
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JP5154944B2 (ja) 2004-12-02 2013-02-27 ビロベイ，インコーポレイティド システインプロテアーゼインヒビターとしてのスルホンアミド含有化合物
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AU7081800A (en) 2001-04-17
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