NO321990B1 - Monoklonale antistoffer mot interleukin-15, farmasoytisk sammensetning inneholdende slike og anvendelse av antistoffene for fremstilling av et medikament for behandling av sykdommer forbundet med IL-15. - Google Patents
Monoklonale antistoffer mot interleukin-15, farmasoytisk sammensetning inneholdende slike og anvendelse av antistoffene for fremstilling av et medikament for behandling av sykdommer forbundet med IL-15. Download PDFInfo
- Publication number
- NO321990B1 NO321990B1 NO19973705A NO973705A NO321990B1 NO 321990 B1 NO321990 B1 NO 321990B1 NO 19973705 A NO19973705 A NO 19973705A NO 973705 A NO973705 A NO 973705A NO 321990 B1 NO321990 B1 NO 321990B1
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- monoclonal antibody
- antibody according
- treatment
- medicament
- antibodies
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/392,317 US5795966A (en) | 1995-02-22 | 1995-02-22 | Antagonists of interleukin-15 |
| PCT/US1996/002520 WO1996026274A1 (en) | 1995-02-22 | 1996-02-21 | Antagonists of interleukin-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO973705D0 NO973705D0 (no) | 1997-08-12 |
| NO973705L NO973705L (no) | 1997-10-22 |
| NO321990B1 true NO321990B1 (no) | 2006-07-31 |
Family
ID=23550114
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19973705A NO321990B1 (no) | 1995-02-22 | 1997-08-12 | Monoklonale antistoffer mot interleukin-15, farmasoytisk sammensetning inneholdende slike og anvendelse av antistoffene for fremstilling av et medikament for behandling av sykdommer forbundet med IL-15. |
| NO20060194A NO20060194L (no) | 1995-02-22 | 2006-01-12 | Antagonister mot interleukin-15 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060194A NO20060194L (no) | 1995-02-22 | 2006-01-12 | Antagonister mot interleukin-15 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US5795966A (pt) |
| EP (2) | EP0811065B2 (pt) |
| JP (2) | JPH11500908A (pt) |
| KR (1) | KR19980702238A (pt) |
| AT (1) | ATE339505T1 (pt) |
| AU (1) | AU708549B2 (pt) |
| CA (2) | CA2210491C (pt) |
| DE (1) | DE69636538T3 (pt) |
| DK (1) | DK0811065T4 (pt) |
| ES (1) | ES2271951T5 (pt) |
| FI (2) | FI120497B (pt) |
| MX (1) | MX9706294A (pt) |
| NO (2) | NO321990B1 (pt) |
| NZ (1) | NZ303843A (pt) |
| PT (1) | PT811065E (pt) |
| WO (1) | WO1996026274A1 (pt) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5574138A (en) | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US7192935B1 (en) * | 1993-03-08 | 2007-03-20 | Amgen Inc. | Polynucleotides encoding epithelium-derived T-cell factor and uses thereof |
| AU680909B2 (en) * | 1994-04-06 | 1997-08-14 | Immunex Corporation | Interleukin-15 |
| US7008624B1 (en) * | 1995-02-22 | 2006-03-07 | Immunex Corporation | Antagonists of interleukin-15 |
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| AUPN378095A0 (en) * | 1995-06-23 | 1995-07-20 | Bresagen Limited | Haemopoietic growth factor antagonists and uses therefor |
| US6451308B1 (en) | 1996-04-26 | 2002-09-17 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
| DK0927254T3 (da) * | 1996-04-26 | 2005-10-03 | Beth Israel Hospital | Interleukin-15-antagonister |
| EP0927254B1 (en) * | 1996-04-26 | 2005-06-22 | Beth Israel Deaconess Medical Center, Inc. | Antagonists of interleukin-15 |
| DE69719529T2 (de) | 1996-10-17 | 2003-12-11 | Immunomedics Inc | Nichtantigenes toxinkonjugat und fusionsprotein eines internalisierendes rezeptorsystems |
| US5874566A (en) * | 1996-10-25 | 1999-02-23 | Hisamitsu Pharmaceutical Co. Inc. | Il-15 triplex oligonucleotides |
| EP1273304B2 (en) * | 1997-02-21 | 2009-07-15 | Amgen Inc. | Use of interleukin-15 |
| JP2002519439A (ja) * | 1998-07-07 | 2002-07-02 | 久光製薬株式会社 | Ｉｌ−１５に標的されたアンチセンスオリゴヌクレオチド |
| GB9814892D0 (en) * | 1998-07-10 | 1998-09-09 | Kennedy Rheumatology Inst | Treatment of celiac disease |
| US5985663A (en) * | 1998-11-25 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of interleukin-15 expression |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| EP1165791B1 (en) * | 1999-03-09 | 2007-10-31 | ZymoGenetics, Inc. | Human cytokine as ligand of the zalpha receptor and uses thereof |
| AU6689700A (en) * | 1999-07-06 | 2001-01-22 | Silvia Bulfone-Paus | Method of treating psoriasis with il-15 antagonist |
| AU7645700A (en) * | 1999-10-07 | 2001-05-10 | Maxygen Aps | Single-chain antagonist polypeptides |
| CA2408691A1 (en) * | 2000-05-12 | 2001-11-22 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for achieving immune suppression |
| ATE427318T1 (de) | 2000-09-14 | 2009-04-15 | Beth Israel Hospital | Modulierung von il-2 und il-15 vermittelten t zellantworten |
| US7049069B2 (en) | 2001-07-17 | 2006-05-23 | University Of Florida | Detecting and treating reproductive tract disorders |
| BR0212136A (pt) * | 2001-08-23 | 2004-12-07 | Genmab As | Anticorpo monoclonal humano isolado, métodos para inibir a produção de tnfa em células t ou monócitos e a proliferação de célula t, hibridoma, transfectoma, animal não humano transgênico, método para produzir um anticorpo monoclonal humano, composição farmacêutica, métodos para tratar ou prevenir um distúrbio mediado pela il-15 humana, a psorìase e a artrite reumatóide, método para diagnosticar uma doença, ácido nucleico, e, vetor de expressão |
| US7247304B2 (en) * | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US7329405B2 (en) * | 2001-08-23 | 2008-02-12 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
| CN101453331A (zh) * | 2002-04-15 | 2009-06-10 | 株式会社Ntt都科摩 | 利用双线性映射的签名方案 |
| CU23093A1 (es) * | 2002-10-09 | 2005-10-19 | Ct Ingenieria Genetica Biotech | Composición vacunal que comprende interleucina-15 (il-15) |
| ZA200506724B (en) * | 2003-02-26 | 2007-03-28 | Genmab As | Human antibodies specific for interleukin 15 (IL-15) |
| DK1656410T3 (da) * | 2003-07-22 | 2010-06-28 | Nektar Therapeutics | Fremgangsmåde til fremstillilng af funktionaliserede polymere fra polymeralkoholer |
| WO2005085282A1 (en) * | 2004-02-27 | 2005-09-15 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Il-15 binding site for il15-ralpha and specific il-15 mutants having agonists/antagonists activity |
| TW200613552A (en) * | 2004-08-11 | 2006-05-01 | Hoffmann La Roche | Mutant interleukin-15 polypeptides |
| CU23472A1 (es) * | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la interleucina-15 |
| AU2005335217A1 (en) * | 2004-10-05 | 2007-02-15 | Ochsner Clinic Foundation | Enhancement of B cell proliferation by IL-15 |
| CA2608474C (en) | 2005-05-17 | 2019-11-12 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| US8055951B2 (en) * | 2007-04-10 | 2011-11-08 | International Business Machines Corporation | System, method and computer program product for evaluating a virtual machine |
| PT2160401E (pt) | 2007-05-11 | 2014-10-30 | Altor Bioscience Corp | Moléculas de fusão e variantes de il-15 |
| CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
| US20100145285A1 (en) * | 2008-12-09 | 2010-06-10 | Cook Critical Care, Incorporated | Multi-lumen catheter configuration |
| US9487800B2 (en) * | 2010-09-08 | 2016-11-08 | Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| DK3327040T3 (da) | 2010-09-21 | 2021-09-20 | Altor Bioscience Corp | Multimeriske opløselige il-15-fusionsmolekyler og fremgangsmåder til at fremstille og anvende samme |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| LT2665486T (lt) | 2011-01-18 | 2020-04-10 | Bioniz, Llc | Kompozicijos, skirtos gama-c-citokino aktyvumui moduliuoti |
| PL2986312T3 (pl) | 2013-04-19 | 2022-04-19 | Cytune Pharma | Oparte na cytokinie leczenie z ograniczeniem zespołu przesiąkania naczyniowego |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| EP3160498B1 (en) | 2014-06-30 | 2021-10-06 | Altor BioScience Corporation | Il-15-based molecules and methods of use thereof |
| US10333696B2 (en) | 2015-01-12 | 2019-06-25 | X-Prime, Inc. | Systems and methods for implementing an efficient, scalable homomorphic transformation of encrypted data with minimal data expansion and improved processing efficiency |
| KR20240047483A (ko) | 2015-10-09 | 2024-04-12 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-ｃ-사이토카인 활성의 조정 |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| WO2017120479A1 (en) * | 2016-01-07 | 2017-07-13 | The Schepens Eye Research Institute, Inc. | Therapeutics for ocular immunoinflammatory diseases |
| EP3468581A1 (en) | 2016-06-13 | 2019-04-17 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| WO2018073248A1 (en) | 2016-10-17 | 2018-04-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Prognosis of demyelinating diseases patients and treatment thereof |
| JP7492336B2 (ja) | 2016-10-21 | 2024-05-29 | アルター・バイオサイエンス・コーポレーション | 多量体ｉｌ－１５に基づく分子 |
| BR112019012570A8 (pt) * | 2016-12-21 | 2023-01-24 | Cephalon Inc | Anticorpos que se ligam especificamente à il-15 humana e seus usos, composição, método in vitro para detecção de il-15 ou um complexo de il-15 e receptor de il-15-alfa, polinucleotídeo, vetor e método de produção do dito anticorpo |
| CU24546B1 (es) | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| CN111432836A (zh) | 2017-09-05 | 2020-07-17 | 转矩医疗股份有限公司 | 治疗性蛋白质组合物及其制备和使用方法 |
| CU24545B1 (es) | 2017-12-29 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Péptido antagonista de la actividad de la interleucina-15 |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| US20230151095A1 (en) | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5071972A (en) | 1986-01-31 | 1991-12-10 | Genetics Institute, Inc. | DNA sequences encoding novel thrombolytic proteins |
| EP0276846A3 (en) | 1987-01-29 | 1989-07-26 | Zymogenetics, Inc. | Colony-stimulating factor derivatives |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| SG89295A1 (en) * | 1991-03-15 | 2002-06-18 | Amgen Inc | Pegylation of polypeptides |
| US5440021A (en) * | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
| EP0627932B1 (en) | 1992-11-04 | 2002-05-08 | City Of Hope | Antibody construct |
| US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| US5574138A (en) * | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US5552303A (en) | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
| US5591630A (en) * | 1994-05-06 | 1997-01-07 | Immunex Corporation | Monoclonal antibodies that bind interleukin-15 receptors |
| US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| DE69637481T2 (de) † | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| AU2466895A (en) † | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
-
1995
- 1995-02-22 US US08/392,317 patent/US5795966A/en not_active Expired - Lifetime
-
1996
- 1996-02-21 CA CA002210491A patent/CA2210491C/en not_active Expired - Fee Related
- 1996-02-21 KR KR1019970705635A patent/KR19980702238A/ko not_active Application Discontinuation
- 1996-02-21 ES ES96907112T patent/ES2271951T5/es not_active Expired - Lifetime
- 1996-02-21 EP EP96907112A patent/EP0811065B2/en not_active Expired - Lifetime
- 1996-02-21 AT AT96907112T patent/ATE339505T1/de active
- 1996-02-21 JP JP8525853A patent/JPH11500908A/ja not_active Withdrawn
- 1996-02-21 PT PT96907112T patent/PT811065E/pt unknown
- 1996-02-21 EP EP06076615A patent/EP1770163A3/en not_active Withdrawn
- 1996-02-21 CA CA2637795A patent/CA2637795C/en not_active Expired - Fee Related
- 1996-02-21 DK DK96907112.5T patent/DK0811065T4/da active
- 1996-02-21 MX MX9706294A patent/MX9706294A/es not_active IP Right Cessation
- 1996-02-21 NZ NZ303843A patent/NZ303843A/en not_active IP Right Cessation
- 1996-02-21 DE DE69636538T patent/DE69636538T3/de not_active Expired - Lifetime
- 1996-02-21 AU AU50275/96A patent/AU708549B2/en not_active Ceased
- 1996-02-21 WO PCT/US1996/002520 patent/WO1996026274A1/en active IP Right Grant
-
1997
- 1997-08-12 NO NO19973705A patent/NO321990B1/no not_active IP Right Cessation
- 1997-08-15 FI FI973361A patent/FI120497B/fi not_active IP Right Cessation
-
1998
- 1998-08-14 US US09/134,134 patent/US6165466A/en not_active Expired - Lifetime
- 1998-08-14 US US09/134,132 patent/US6013480A/en not_active Expired - Lifetime
- 1998-08-14 US US09/134,456 patent/US6168783B1/en not_active Expired - Lifetime
- 1998-11-20 US US09/196,427 patent/US6177079B1/en not_active Expired - Lifetime
-
2006
- 2006-01-12 NO NO20060194A patent/NO20060194L/no unknown
- 2006-01-27 FI FI20060080A patent/FI121571B/fi not_active IP Right Cessation
-
2007
- 2007-11-12 JP JP2007293169A patent/JP2008133276A/ja not_active Revoked
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