NO321697B1 - Indol derivater - Google Patents
Indol derivater Download PDFInfo
- Publication number
- NO321697B1 NO321697B1 NO20015737A NO20015737A NO321697B1 NO 321697 B1 NO321697 B1 NO 321697B1 NO 20015737 A NO20015737 A NO 20015737A NO 20015737 A NO20015737 A NO 20015737A NO 321697 B1 NO321697 B1 NO 321697B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- aryl
- phenoxy
- group
- alkoxy
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title description 3
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 63
- -1 2-dihydrofuryl Chemical group 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 48
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical group 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 210000002307 prostate Anatomy 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 11
- 238000013461 design Methods 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims description 9
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 8
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- HUUAJMLMTVDSQW-UHFFFAOYSA-N 2-(5-methoxy-1h-indol-3-yl)-n-(oxolan-2-ylmethyl)ethanamine Chemical compound C12=CC(OC)=CC=C2NC=C1CCNCC1CCCO1 HUUAJMLMTVDSQW-UHFFFAOYSA-N 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 210000003169 central nervous system Anatomy 0.000 claims description 6
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims description 6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL130169A IL130169A (en) | 1999-05-27 | 1999-05-27 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| PCT/IL2000/000295 WO2000072815A1 (en) | 1999-05-27 | 2000-05-24 | Indole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20015737D0 NO20015737D0 (no) | 2001-11-26 |
| NO20015737L NO20015737L (no) | 2002-01-25 |
| NO321697B1 true NO321697B1 (no) | 2006-06-26 |
Family
ID=11072850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20015737A NO321697B1 (no) | 1999-05-27 | 2001-11-26 | Indol derivater |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6858642B1 (sk) |
| EP (1) | EP1189583B1 (sk) |
| JP (1) | JP3840378B2 (sk) |
| KR (1) | KR100749991B1 (sk) |
| CN (1) | CN100425592C (sk) |
| AR (1) | AR029362A1 (sk) |
| AT (1) | ATE299876T1 (sk) |
| AU (1) | AU776968B2 (sk) |
| BG (1) | BG65379B1 (sk) |
| BR (1) | BR0012184B1 (sk) |
| CA (1) | CA2374158C (sk) |
| CY (1) | CY1106049T1 (sk) |
| CZ (1) | CZ300126B6 (sk) |
| DE (1) | DE60021384T2 (sk) |
| DK (1) | DK1189583T3 (sk) |
| EA (1) | EA008907B1 (sk) |
| EE (1) | EE04675B1 (sk) |
| ES (1) | ES2246235T3 (sk) |
| HK (1) | HK1047049B (sk) |
| HU (1) | HU226776B1 (sk) |
| IL (1) | IL130169A (sk) |
| IS (1) | IS2262B (sk) |
| MX (1) | MXPA01012041A (sk) |
| NO (1) | NO321697B1 (sk) |
| NZ (1) | NZ515867A (sk) |
| PE (1) | PE20010149A1 (sk) |
| PL (1) | PL212987B1 (sk) |
| PT (1) | PT1189583E (sk) |
| SK (1) | SK285173B6 (sk) |
| TN (1) | TNSN00118A1 (sk) |
| TR (1) | TR200103417T2 (sk) |
| TW (1) | TWI285634B (sk) |
| UA (1) | UA73507C2 (sk) |
| WO (1) | WO2000072815A1 (sk) |
| ZA (1) | ZA200110437B (sk) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| MC200060A1 (fr) * | 2002-10-04 | 2003-05-28 | M Exsymol Sa | Produit de couplage entre la tryptamine et un alpha-aminoacide son procédé de préparation et son application dans le domaine de la neuro-cosmétique |
| KR100776118B1 (ko) | 2002-11-28 | 2007-11-15 | 수벤 라이프 사이언시스 리미티드 | 엔-아릴술포닐-3-아미노알콕시인돌 |
| JP4571507B2 (ja) | 2002-12-18 | 2010-10-27 | スベン ライフ サイエンシズ リミティド | セロトニン受容体親和性を有する四環系３−置換インドール |
| WO2005062851A2 (en) * | 2003-12-22 | 2005-07-14 | Pappolla Miguel A | Indole-3-propionamide and derivatives thereof |
| CA2556753C (en) * | 2004-02-20 | 2014-11-25 | Lifescape Biosciences Incorporated | Compositions and methods for sleep regulation |
| US7635710B2 (en) * | 2006-02-15 | 2009-12-22 | Neurim Pharmaceuticals (1991) Ltd. | Pyrone-indole derivatives and process for their preparation |
| US9101613B2 (en) | 2006-02-15 | 2015-08-11 | Neurim Pharmaceuticals (1991) Ltd. | Methods for treating neurological disease |
| US8094815B2 (en) * | 2006-11-13 | 2012-01-10 | Electronics Andtelecommunications Research Institute | Arithmetic method and apparatus for supporting AES and ARIA encryption/decryption functions |
| TW201119651A (en) * | 2009-10-26 | 2011-06-16 | Lg Life Sciences Ltd | Pharmaceutical composition comprising indole compound |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| FR2984122B1 (fr) * | 2011-12-16 | 2014-08-01 | Syntivia | Composition cosmetique pour stimuler les fonctions cellulaires anti-vieillissement de la peau |
| CN102584672A (zh) * | 2012-01-11 | 2012-07-18 | 合肥工业大学 | 一种5-甲氧基色胺衍生物、其制备方法及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04501722A (ja) * | 1988-11-14 | 1992-03-26 | ジ・アップジョン・カンパニー | 抗―糖尿病、抗―肥満症および抗―アテローム性動脈硬化症薬として有用なα―アミノ―インドール―３―酢酸 |
| AU8876591A (en) * | 1990-11-02 | 1992-05-26 | Upjohn Company, The | Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| US5403851A (en) * | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| IL113313A (en) * | 1994-04-11 | 1999-09-22 | Sankyo Co | Heterocyclic compounds and pharmaceutical compositions containing the same |
| JPH08239362A (ja) * | 1994-12-28 | 1996-09-17 | Sankyo Co Ltd | インドール誘導体 |
| US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
| US5756507A (en) * | 1995-12-14 | 1998-05-26 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1997023202A1 (en) * | 1995-12-22 | 1997-07-03 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON | Subtype-selective nmda receptor ligands and the use thereof |
| JPH09227369A (ja) * | 1996-02-27 | 1997-09-02 | Kyoichi Kobashi | 抗ヘリコバクター・ピロリ剤 |
| GB9718833D0 (en) * | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
-
1999
- 1999-05-27 IL IL130169A patent/IL130169A/en not_active IP Right Cessation
-
2000
- 2000-05-24 NZ NZ515867A patent/NZ515867A/en not_active IP Right Cessation
- 2000-05-24 AT AT00927703T patent/ATE299876T1/de active
- 2000-05-24 DE DE60021384T patent/DE60021384T2/de not_active Expired - Lifetime
- 2000-05-24 MX MXPA01012041A patent/MXPA01012041A/es active IP Right Grant
- 2000-05-24 KR KR1020017014959A patent/KR100749991B1/ko not_active IP Right Cessation
- 2000-05-24 HU HU0201338A patent/HU226776B1/hu not_active IP Right Cessation
- 2000-05-24 CN CNB008081050A patent/CN100425592C/zh not_active Expired - Fee Related
- 2000-05-24 TR TR2001/03417T patent/TR200103417T2/xx unknown
- 2000-05-24 EP EP00927703A patent/EP1189583B1/en not_active Expired - Lifetime
- 2000-05-24 UA UA2001128827A patent/UA73507C2/uk unknown
- 2000-05-24 JP JP2000620927A patent/JP3840378B2/ja not_active Expired - Fee Related
- 2000-05-24 PL PL351884A patent/PL212987B1/pl unknown
- 2000-05-24 PT PT00927703T patent/PT1189583E/pt unknown
- 2000-05-24 ES ES00927703T patent/ES2246235T3/es not_active Expired - Lifetime
- 2000-05-24 CA CA002374158A patent/CA2374158C/en not_active Expired - Fee Related
- 2000-05-24 SK SK1643-2001A patent/SK285173B6/sk not_active IP Right Cessation
- 2000-05-24 DK DK00927703T patent/DK1189583T3/da active
- 2000-05-24 EA EA200101241A patent/EA008907B1/ru not_active IP Right Cessation
- 2000-05-24 EE EEP200100624A patent/EE04675B1/xx not_active IP Right Cessation
- 2000-05-24 BR BRPI0012184-3B1A patent/BR0012184B1/pt not_active IP Right Cessation
- 2000-05-24 AU AU46088/00A patent/AU776968B2/en not_active Ceased
- 2000-05-24 US US09/979,658 patent/US6858642B1/en not_active Expired - Fee Related
- 2000-05-24 CZ CZ20014191A patent/CZ300126B6/cs not_active IP Right Cessation
- 2000-05-24 WO PCT/IL2000/000295 patent/WO2000072815A1/en not_active Application Discontinuation
- 2000-05-26 TN TNTNSN00118A patent/TNSN00118A1/fr unknown
- 2000-05-26 PE PE2000000504A patent/PE20010149A1/es not_active Application Discontinuation
- 2000-05-26 AR ARP000102568A patent/AR029362A1/es not_active Application Discontinuation
- 2000-05-31 TW TW089110620A patent/TWI285634B/zh not_active IP Right Cessation
-
2001
- 2001-11-22 IS IS6171A patent/IS2262B/is unknown
- 2001-11-26 NO NO20015737A patent/NO321697B1/no not_active IP Right Cessation
- 2001-12-18 BG BG106233A patent/BG65379B1/bg unknown
- 2001-12-20 ZA ZA200110437A patent/ZA200110437B/en unknown
-
2002
- 2002-11-29 HK HK02108725.3A patent/HK1047049B/zh not_active IP Right Cessation
-
2005
- 2005-01-11 US US11/032,057 patent/US7355054B2/en not_active Expired - Fee Related
- 2005-10-11 CY CY20051101228T patent/CY1106049T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |