NO319824B1 - Pyrazolkarboksylsyrederivater, deres fremstilling og anvendelse og farmasoytiske preparater inneholdende de samme, samt mellomproduktforbindelser. - Google Patents
Pyrazolkarboksylsyrederivater, deres fremstilling og anvendelse og farmasoytiske preparater inneholdende de samme, samt mellomproduktforbindelser. Download PDFInfo
- Publication number
- NO319824B1 NO319824B1 NO20013736A NO20013736A NO319824B1 NO 319824 B1 NO319824 B1 NO 319824B1 NO 20013736 A NO20013736 A NO 20013736A NO 20013736 A NO20013736 A NO 20013736A NO 319824 B1 NO319824 B1 NO 319824B1
- Authority
- NO
- Norway
- Prior art keywords
- dichlorophenyl
- compound
- formula
- bromophenyl
- acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 62
- 238000002360 preparation method Methods 0.000 title claims description 14
- KOPFEFZSAMLEHK-UHFFFAOYSA-N 1h-pyrazole-5-carboxylic acid Chemical class OC(=O)C=1C=CNN=1 KOPFEFZSAMLEHK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 20
- 125000005907 alkyl ester group Chemical group 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 239000012453 solvate Substances 0.000 claims description 13
- 230000009471 action Effects 0.000 claims description 11
- PFWFPIDDESKTDC-UHFFFAOYSA-N 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid Chemical class CCC=1C(C(O)=O)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Br)C=C1 PFWFPIDDESKTDC-UHFFFAOYSA-N 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- UHCAAOYUQXTCLC-UHFFFAOYSA-N 3-(4-bromobenzoyl)-2-oxopentanoic acid Chemical compound OC(=O)C(=O)C(CC)C(=O)C1=CC=C(Br)C=C1 UHCAAOYUQXTCLC-UHFFFAOYSA-N 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 8
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims description 8
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- ZTPAUBJZUBGGEY-UHFFFAOYSA-N (2,4-dichlorophenyl)hydrazine Chemical class NNC1=CC=C(Cl)C=C1Cl ZTPAUBJZUBGGEY-UHFFFAOYSA-N 0.000 claims description 5
- HMXDWDSNPRNUKI-UHFFFAOYSA-N 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-3-pyrazolecarboxamide Chemical group CCC=1C(C(=O)NN2CCCCC2)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Br)C=C1 HMXDWDSNPRNUKI-UHFFFAOYSA-N 0.000 claims description 5
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- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 4
- -1 p-nitrophenyl ester Chemical class 0.000 description 4
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 description 4
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR9901201A FR2789078B3 (fr) | 1999-02-01 | 1999-02-01 | Derives d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
FR9910166A FR2789079B3 (fr) | 1999-02-01 | 1999-08-02 | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
PCT/FR2000/000194 WO2000046209A1 (fr) | 1999-02-01 | 2000-01-28 | Derives d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
Publications (3)
Publication Number | Publication Date |
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NO20013736D0 NO20013736D0 (no) | 2001-07-30 |
NO20013736L NO20013736L (no) | 2001-09-28 |
NO319824B1 true NO319824B1 (no) | 2005-09-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20013736A NO319824B1 (no) | 1999-02-01 | 2001-07-30 | Pyrazolkarboksylsyrederivater, deres fremstilling og anvendelse og farmasoytiske preparater inneholdende de samme, samt mellomproduktforbindelser. |
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US (3) | US6432984B1 (zh) |
EP (1) | EP1150961B1 (zh) |
JP (1) | JP3794925B2 (zh) |
KR (1) | KR100425405B1 (zh) |
CN (1) | CN1146544C (zh) |
AR (1) | AR020558A1 (zh) |
AT (1) | ATE252562T1 (zh) |
AU (1) | AU754771B2 (zh) |
BG (1) | BG65193B1 (zh) |
BR (1) | BR0007895A (zh) |
CA (1) | CA2358885C (zh) |
CO (1) | CO5160257A1 (zh) |
CZ (1) | CZ297667B6 (zh) |
DE (1) | DE60006070T2 (zh) |
DK (1) | DK1150961T3 (zh) |
EE (1) | EE04343B1 (zh) |
ES (1) | ES2208267T3 (zh) |
FR (1) | FR2789079B3 (zh) |
HK (1) | HK1039329A1 (zh) |
HR (1) | HRP20010564B1 (zh) |
HU (1) | HUP0201278A3 (zh) |
ID (1) | ID29534A (zh) |
IL (2) | IL144198A0 (zh) |
IS (1) | IS2448B (zh) |
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NO (1) | NO319824B1 (zh) |
NZ (1) | NZ512886A (zh) |
PE (1) | PE20001493A1 (zh) |
PL (1) | PL198422B1 (zh) |
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RS (1) | RS50209B (zh) |
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TW (1) | TW581764B (zh) |
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EA201690938A1 (ru) | 2013-11-05 | 2016-11-30 | Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити | Соединения для лечения диабета и осложнений, возникающих из-за этого заболевания |
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Family Cites Families (5)
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FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
FR2714057B1 (fr) * | 1993-12-17 | 1996-03-08 | Sanofi Elf | Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
FR2741621B1 (fr) * | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
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1999
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2000
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- 2000-01-28 AU AU22989/00A patent/AU754771B2/en not_active Ceased
- 2000-01-28 KR KR10-2001-7009572A patent/KR100425405B1/ko not_active IP Right Cessation
- 2000-01-28 PE PE2000000066A patent/PE20001493A1/es not_active Application Discontinuation
- 2000-01-28 AT AT00901661T patent/ATE252562T1/de active
- 2000-01-28 RU RU2001121186/04A patent/RU2216542C2/ru not_active IP Right Cessation
- 2000-01-28 RS YUP-539/01A patent/RS50209B/sr unknown
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