FR2849032B1 - Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique - Google Patents

Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique

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Publication number
FR2849032B1
FR2849032B1 FR0216688A FR0216688A FR2849032B1 FR 2849032 B1 FR2849032 B1 FR 2849032B1 FR 0216688 A FR0216688 A FR 0216688A FR 0216688 A FR0216688 A FR 0216688A FR 2849032 B1 FR2849032 B1 FR 2849032B1
Authority
FR
France
Prior art keywords
bromophenyl
dichlorophenyl
piperidin
pyrazole
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0216688A
Other languages
English (en)
Other versions
FR2849032A1 (fr
Inventor
Gilles Miscoria
Murielle Rinaldi
Joseph Schofield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to FR0216688A priority Critical patent/FR2849032B1/fr
Priority to JP2004563272A priority patent/JP2006513197A/ja
Priority to PCT/FR2003/003814 priority patent/WO2004058744A1/fr
Priority to AU2003299362A priority patent/AU2003299362A1/en
Priority to EP03799645A priority patent/EP1583758A1/fr
Publication of FR2849032A1 publication Critical patent/FR2849032A1/fr
Priority to US11/159,779 priority patent/US20060004055A1/en
Application granted granted Critical
Publication of FR2849032B1 publication Critical patent/FR2849032B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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FR0216688A 2002-12-23 2002-12-23 Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique Expired - Fee Related FR2849032B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0216688A FR2849032B1 (fr) 2002-12-23 2002-12-23 Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique
JP2004563272A JP2006513197A (ja) 2002-12-23 2003-12-19 ５−（４−ブロモフェニル）−１−（２，４−ジクロロフェニル）−４−エチル−ｎ−（ピペリジン−１−イル）−１ｈ−ピラゾール−３−カルボキサミド誘導体、それらの製造法および治療用途
PCT/FR2003/003814 WO2004058744A1 (fr) 2002-12-23 2003-12-19 Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenly)-4-ethyl-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation son application en therapeutique
AU2003299362A AU2003299362A1 (en) 2002-12-23 2003-12-19 Derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenly)-4-ethyl-n-(piperidine-1-yl)-1h-pyrazol-3-carboxamide, the preparation and therapeutic use thereof
EP03799645A EP1583758A1 (fr) 2002-12-23 2003-12-19 Dérivé de 5-(4-bromophenyl)-1-(2,4-dichlorophenly)-4-ethyl-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa préparation son application en therapeutique
US11/159,779 US20060004055A1 (en) 2002-12-23 2005-06-23 Derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(piperidine-1-yl)-1H-pyrazole-3-carboxamide, the preparation and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0216688A FR2849032B1 (fr) 2002-12-23 2002-12-23 Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique

Publications (2)

Publication Number Publication Date
FR2849032A1 FR2849032A1 (fr) 2004-06-25
FR2849032B1 true FR2849032B1 (fr) 2006-04-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR0216688A Expired - Fee Related FR2849032B1 (fr) 2002-12-23 2002-12-23 Derive de 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-n -(piperidin-1-yl)-1h-pyrazole-3-carboxamide, sa preparation, son application en therapeuthique

Country Status (6)

Country Link
US (1) US20060004055A1 (fr)
EP (1) EP1583758A1 (fr)
JP (1) JP2006513197A (fr)
AU (1) AU2003299362A1 (fr)
FR (1) FR2849032B1 (fr)
WO (1) WO2004058744A1 (fr)

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AU2002319627A1 (en) 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
NZ534757A (en) 2002-03-12 2006-07-28 Merck & Co Inc Substituted amides
EP1574211A1 (fr) * 2004-03-09 2005-09-14 Inserm Utilisation d'antagonistes des récepteurs CB1 pour la fabrication d'un médicament destiné au traitement des maladies hépatiques
US8084451B2 (en) * 2005-01-10 2011-12-27 University Of Connecticut Heteropyrrole analogs acting on cannabinoid receptors
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
EP1902034B1 (fr) 2005-06-02 2011-03-30 Glenmark Pharmaceuticals S.A. Nouveaux ligands des recepteurs des cannabinoides, compositions pharmaceutiques contenant ces ligands, et procede servant a leur preparation
JP5069894B2 (ja) * 2005-10-21 2012-11-07 田辺三菱製薬株式会社 ピラゾール化合物
RU2009108280A (ru) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение
HUP0600925A3 (en) * 2006-12-19 2009-03-30 Richter Gedeon Nyrt Dyaril-pyrazoles as cb1 antagonists, their use and pharmaceutical compositions containine them
JP4994295B2 (ja) * 2007-04-20 2012-08-08 田辺三菱製薬株式会社 医薬組成物
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
TW201014822A (en) 2008-07-09 2010-04-16 Sanofi Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
JP2013503135A (ja) 2009-08-26 2013-01-31 サノフイ 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
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US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120051A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation
EP2683701B1 (fr) 2011-03-08 2014-12-24 Sanofi Dérivés d'oxathiazine substitués par des groupes de benzyle-méthyles ou d'hétéro-méthyles, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2683700B1 (fr) 2011-03-08 2015-02-18 Sanofi Dérivés d'oxathiazine tétra-substitués, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation
EP2766349B1 (fr) 2011-03-08 2016-06-01 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation

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US20020091114A1 (en) * 2000-10-04 2002-07-11 Odile Piot-Grosjean Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity

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AU2003299362A1 (en) 2004-07-22
US20060004055A1 (en) 2006-01-05
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FR2849032A1 (fr) 2004-06-25
JP2006513197A (ja) 2006-04-20

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