NO318761B1 - Polypeptidanalog til nativ keratinocyttvekstfaktor kalt "KGF", farmasoytisk formulering, rekombinant nukleinsyremolekyl, biologisk funksjonell vektor, prokaryot eller eukaryot vertscelle, fremgangsmate for fremstilling av en analog av KGF, anvendelse av en effektiv mengde av analogen av KGF i folge oppfinnelsen, eller deltaN23 for fremstilling av et medikament for stimulering av produksjon av ikke-fibroblastepitelceller, in vitro fremgangsmate for stimulering av produksjon av ikke-fibroblastepitelceller samt sett. - Google Patents

Polypeptidanalog til nativ keratinocyttvekstfaktor kalt "KGF", farmasoytisk formulering, rekombinant nukleinsyremolekyl, biologisk funksjonell vektor, prokaryot eller eukaryot vertscelle, fremgangsmate for fremstilling av en analog av KGF, anvendelse av en effektiv mengde av analogen av KGF i folge oppfinnelsen, eller deltaN23 for fremstilling av et medikament for stimulering av produksjon av ikke-fibroblastepitelceller, in vitro fremgangsmate for stimulering av produksjon av ikke-fibroblastepitelceller samt sett. Download PDF

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Publication number
NO318761B1
NO318761B1 NO19971568A NO971568A NO318761B1 NO 318761 B1 NO318761 B1 NO 318761B1 NO 19971568 A NO19971568 A NO 19971568A NO 971568 A NO971568 A NO 971568A NO 318761 B1 NO318761 B1 NO 318761B1
Authority
NO
Norway
Prior art keywords
kgf
amino acid
analogue
acid position
epithelial cells
Prior art date
Application number
NO19971568A
Other languages
English (en)
Norwegian (no)
Other versions
NO971568D0 (no
NO971568L (no
Inventor
Charles F Morris
Eric W Hsu
William C Kenney
Bao-Lu Chen
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of NO971568D0 publication Critical patent/NO971568D0/no
Publication of NO971568L publication Critical patent/NO971568L/no
Publication of NO318761B1 publication Critical patent/NO318761B1/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO19971568A 1994-10-13 1997-04-04 Polypeptidanalog til nativ keratinocyttvekstfaktor kalt "KGF", farmasoytisk formulering, rekombinant nukleinsyremolekyl, biologisk funksjonell vektor, prokaryot eller eukaryot vertscelle, fremgangsmate for fremstilling av en analog av KGF, anvendelse av en effektiv mengde av analogen av KGF i folge oppfinnelsen, eller deltaN23 for fremstilling av et medikament for stimulering av produksjon av ikke-fibroblastepitelceller, in vitro fremgangsmate for stimulering av produksjon av ikke-fibroblastepitelceller samt sett. NO318761B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000971 WO1996011949A2 (en) 1994-10-13 1995-10-12 Analogs of keratinocyte growth factor

Publications (3)

Publication Number Publication Date
NO971568D0 NO971568D0 (no) 1997-04-04
NO971568L NO971568L (no) 1997-06-12
NO318761B1 true NO318761B1 (no) 2005-05-02

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19971568A NO318761B1 (no) 1994-10-13 1997-04-04 Polypeptidanalog til nativ keratinocyttvekstfaktor kalt "KGF", farmasoytisk formulering, rekombinant nukleinsyremolekyl, biologisk funksjonell vektor, prokaryot eller eukaryot vertscelle, fremgangsmate for fremstilling av en analog av KGF, anvendelse av en effektiv mengde av analogen av KGF i folge oppfinnelsen, eller deltaN23 for fremstilling av et medikament for stimulering av produksjon av ikke-fibroblastepitelceller, in vitro fremgangsmate for stimulering av produksjon av ikke-fibroblastepitelceller samt sett.
NO971566A NO971566L (no) 1994-10-13 1997-04-04 Fremgangsmåte for behandling av diabetes mellitus ved anvendelse av KGF

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO971566A NO971566L (no) 1994-10-13 1997-04-04 Fremgangsmåte for behandling av diabetes mellitus ved anvendelse av KGF

Country Status (23)

Country Link
EP (2) EP0785948B1 (es)
JP (2) JP4216329B2 (es)
KR (1) KR100278597B1 (es)
CN (1) CN1168678A (es)
AT (2) ATE237633T1 (es)
AU (1) AU3707795A (es)
BG (2) BG101392A (es)
BR (2) BR9509269A (es)
CA (2) CA2201940C (es)
CZ (3) CZ297328B6 (es)
DE (2) DE69530403T2 (es)
DK (2) DK0804479T3 (es)
EE (2) EE03975B1 (es)
ES (2) ES2196082T3 (es)
FI (2) FI971420A (es)
HU (2) HUT78050A (es)
NO (2) NO318761B1 (es)
NZ (2) NZ505502A (es)
PL (2) PL320484A1 (es)
PT (2) PT804479E (es)
SI (2) SI0804479T1 (es)
SK (2) SK284534B6 (es)
WO (2) WO1996011950A1 (es)

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HU218090B (hu) 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
EP0706563B1 (en) 1993-06-29 2004-10-06 Chiron Corporation A truncated keratinocyte growth factor (kgf) having increased biological activity
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
JP3877226B2 (ja) * 1994-10-13 2007-02-07 アムジエン・インコーポレーテツド ケラチノサイト成長因子の精製法
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
AU5410196A (en) * 1995-04-27 1996-11-18 Cooperatie Suiker Unie U.A. Inulin derivatives
SI0935652T1 (en) * 1996-10-15 2004-06-30 Amgen Inc. Keratinocyte growth factor-2 products
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
GB2322132B (en) * 1996-10-15 1999-09-22 Amgen Inc Keratinocyte growth factor-2 products
CN1269805A (zh) 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
AU1905799A (en) 1997-12-22 1999-07-12 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
NZ513077A (en) * 1999-01-14 2004-03-26 Bolder Biotechnology Inc Methods for making proteins containing free cysteine residues
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
WO2002062842A1 (en) * 2001-02-06 2002-08-15 Merck Patent Gmbh Modified keratinocyte growth factor (kgf) with reduced immunogenicity
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
JP2005500390A (ja) * 2001-08-21 2005-01-06 カイロン コーポレイション Kgfポリペプチド組成物
JP5201992B2 (ja) 2004-12-15 2013-06-05 バイオビトラム・アクテイエボラーグ(パブリツク) ケラチノサイト増殖因子の治療用製剤
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

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Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd reg蛋白質
CA1306456C (en) * 1988-07-27 1992-08-18 Marjan International Pty. Ltd. Carpet stretcher
HU218090B (hu) * 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 bFGFムテインおよびその製造法
AU707340B2 (en) * 1993-03-26 1999-07-08 Biovitrum Ab (Publ) Therapeutic uses of keratinocyte growth factor
EP0706563B1 (en) * 1993-06-29 2004-10-06 Chiron Corporation A truncated keratinocyte growth factor (kgf) having increased biological activity
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
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Also Published As

Publication number Publication date
EE9700081A (et) 1997-10-15
AU681546B2 (en) 1997-08-28
EE03975B1 (et) 2003-02-17
JP4216329B2 (ja) 2009-01-28
PL182888B1 (pl) 2002-03-29
DE69535264D1 (de) 2006-11-23
CZ297328B6 (cs) 2006-11-15
EE9700225A (et) 1998-02-16
SK284534B6 (sk) 2005-06-02
DK0804479T3 (da) 2007-01-29
PT785948E (pt) 2003-09-30
DE69535264T2 (de) 2007-02-01
NO971566D0 (no) 1997-04-04
CZ98197A3 (cs) 1998-11-11
HU226168B1 (en) 2008-05-28
PT804479E (pt) 2007-02-28
JPH10507080A (ja) 1998-07-14
EP0785948B1 (en) 2003-04-16
BR9509269A (pt) 1997-12-23
ATE342278T1 (de) 2006-11-15
EP0785948A1 (en) 1997-07-30
NZ505502A (en) 2005-01-28
JP4426646B2 (ja) 2010-03-03
NO971568D0 (no) 1997-04-04
AU3707795A (en) 1996-05-06
BG63167B1 (bg) 2001-05-31
ES2273338T3 (es) 2007-05-01
SI0804479T1 (sl) 2006-12-31
CZ297329B6 (cs) 2006-11-15
NO971568L (no) 1997-06-12
JPH10507193A (ja) 1998-07-14
FI971536A (fi) 1997-06-09
NZ335109A (en) 2000-08-25
ATE237633T1 (de) 2003-05-15
HUT78058A (hu) 1999-07-28
CA2201940A1 (en) 1996-04-25
FI971420A0 (fi) 1997-04-04
SI0785948T1 (en) 2003-08-31
BG101392A (en) 1997-10-31
CN1168678A (zh) 1997-12-24
FI971420A (fi) 1997-04-04
SK45597A3 (en) 1999-02-11
CA2202075A1 (en) 1996-04-25
ES2196082T3 (es) 2003-12-16
NO971566L (no) 1997-04-14
CA2201940C (en) 2009-05-12
HUT78050A (hu) 1999-07-28
DE69530403T2 (de) 2003-10-30
WO1996011950A1 (en) 1996-04-25
BR9509329A (pt) 1997-10-14
DK0785948T3 (da) 2003-08-04
EP0804479B1 (en) 2006-10-11
AU3708395A (en) 1996-05-06
KR100278597B1 (ko) 2001-01-15
CA2202075C (en) 2003-12-09
WO1996011949A2 (en) 1996-04-25
PL319784A1 (en) 1997-08-18
FI971536A0 (fi) 1997-04-11
FI120040B (fi) 2009-06-15
BG101408A (en) 1997-12-30
CZ105097A3 (cs) 1998-10-14
EP0804479A1 (en) 1997-11-05
DE69530403D1 (de) 2003-05-22
SK43197A3 (en) 1999-03-12
PL320484A1 (en) 1997-09-29
WO1996011949A3 (en) 1996-12-12

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