BG101392A - Method of treating diabetes mellitus using kgf - Google Patents

Method of treating diabetes mellitus using kgf

Info

Publication number
BG101392A
BG101392A BG101392A BG10139297A BG101392A BG 101392 A BG101392 A BG 101392A BG 101392 A BG101392 A BG 101392A BG 10139297 A BG10139297 A BG 10139297A BG 101392 A BG101392 A BG 101392A
Authority
BG
Bulgaria
Prior art keywords
kgf
diabetes mellitus
treating diabetes
mammals
pharmaceutical compositions
Prior art date
Application number
BG101392A
Other languages
Bulgarian (bg)
English (en)
Inventor
Lea Aukerman
Francis Pierce
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of BG101392A publication Critical patent/BG101392A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG101392A 1994-10-13 1997-04-07 Method of treating diabetes mellitus using kgf BG101392A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000992 WO1996011950A1 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf

Publications (1)

Publication Number Publication Date
BG101392A true BG101392A (en) 1997-10-31

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
BG101392A BG101392A (en) 1994-10-13 1997-04-07 Method of treating diabetes mellitus using kgf
BG101408A BG63167B1 (bg) 1994-10-13 1997-04-11 Аналози на кератиноцитния растежен фактор

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG101408A BG63167B1 (bg) 1994-10-13 1997-04-11 Аналози на кератиноцитния растежен фактор

Country Status (23)

Country Link
EP (2) EP0785948B1 (es)
JP (2) JP4216329B2 (es)
KR (1) KR100278597B1 (es)
CN (1) CN1168678A (es)
AT (2) ATE237633T1 (es)
AU (1) AU3707795A (es)
BG (2) BG101392A (es)
BR (2) BR9509269A (es)
CA (2) CA2201940C (es)
CZ (3) CZ297328B6 (es)
DE (2) DE69530403T2 (es)
DK (2) DK0804479T3 (es)
EE (2) EE03975B1 (es)
ES (2) ES2196082T3 (es)
FI (2) FI971420A (es)
HU (2) HUT78050A (es)
NO (2) NO318761B1 (es)
NZ (2) NZ505502A (es)
PL (2) PL320484A1 (es)
PT (2) PT804479E (es)
SI (2) SI0804479T1 (es)
SK (2) SK284534B6 (es)
WO (2) WO1996011950A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218090B (hu) 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
EP0706563B1 (en) 1993-06-29 2004-10-06 Chiron Corporation A truncated keratinocyte growth factor (kgf) having increased biological activity
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
JP3877226B2 (ja) * 1994-10-13 2007-02-07 アムジエン・インコーポレーテツド ケラチノサイト成長因子の精製法
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
AU5410196A (en) * 1995-04-27 1996-11-18 Cooperatie Suiker Unie U.A. Inulin derivatives
SI0935652T1 (en) * 1996-10-15 2004-06-30 Amgen Inc. Keratinocyte growth factor-2 products
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
GB2322132B (en) * 1996-10-15 1999-09-22 Amgen Inc Keratinocyte growth factor-2 products
CN1269805A (zh) 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
AU1905799A (en) 1997-12-22 1999-07-12 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
NZ513077A (en) * 1999-01-14 2004-03-26 Bolder Biotechnology Inc Methods for making proteins containing free cysteine residues
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
WO2002062842A1 (en) * 2001-02-06 2002-08-15 Merck Patent Gmbh Modified keratinocyte growth factor (kgf) with reduced immunogenicity
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
JP2005500390A (ja) * 2001-08-21 2005-01-06 カイロン コーポレイション Ｋｇｆポリペプチド組成物
JP5201992B2 (ja) 2004-12-15 2013-06-05 バイオビトラム・アクテイエボラーグ（パブリツク） ケラチノサイト増殖因子の治療用製剤
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd ｒｅｇ蛋白質
CA1306456C (en) * 1988-07-27 1992-08-18 Marjan International Pty. Ltd. Carpet stretcher
HU218090B (hu) * 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
AU707340B2 (en) * 1993-03-26 1999-07-08 Biovitrum Ab (Publ) Therapeutic uses of keratinocyte growth factor
EP0706563B1 (en) * 1993-06-29 2004-10-06 Chiron Corporation A truncated keratinocyte growth factor (kgf) having increased biological activity
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
EP0712314A1 (en) * 1993-08-02 1996-05-22 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates

Also Published As

Publication number Publication date
EE9700081A (et) 1997-10-15
AU681546B2 (en) 1997-08-28
EE03975B1 (et) 2003-02-17
JP4216329B2 (ja) 2009-01-28
PL182888B1 (pl) 2002-03-29
DE69535264D1 (de) 2006-11-23
CZ297328B6 (cs) 2006-11-15
EE9700225A (et) 1998-02-16
SK284534B6 (sk) 2005-06-02
DK0804479T3 (da) 2007-01-29
PT785948E (pt) 2003-09-30
DE69535264T2 (de) 2007-02-01
NO971566D0 (no) 1997-04-04
CZ98197A3 (cs) 1998-11-11
HU226168B1 (en) 2008-05-28
PT804479E (pt) 2007-02-28
JPH10507080A (ja) 1998-07-14
EP0785948B1 (en) 2003-04-16
BR9509269A (pt) 1997-12-23
ATE342278T1 (de) 2006-11-15
EP0785948A1 (en) 1997-07-30
NZ505502A (en) 2005-01-28
JP4426646B2 (ja) 2010-03-03
NO971568D0 (no) 1997-04-04
AU3707795A (en) 1996-05-06
BG63167B1 (bg) 2001-05-31
ES2273338T3 (es) 2007-05-01
SI0804479T1 (sl) 2006-12-31
CZ297329B6 (cs) 2006-11-15
NO971568L (no) 1997-06-12
JPH10507193A (ja) 1998-07-14
FI971536A (fi) 1997-06-09
NZ335109A (en) 2000-08-25
ATE237633T1 (de) 2003-05-15
HUT78058A (hu) 1999-07-28
CA2201940A1 (en) 1996-04-25
FI971420A0 (fi) 1997-04-04
SI0785948T1 (en) 2003-08-31
CN1168678A (zh) 1997-12-24
FI971420A (fi) 1997-04-04
SK45597A3 (en) 1999-02-11
CA2202075A1 (en) 1996-04-25
ES2196082T3 (es) 2003-12-16
NO971566L (no) 1997-04-14
CA2201940C (en) 2009-05-12
HUT78050A (hu) 1999-07-28
DE69530403T2 (de) 2003-10-30
WO1996011950A1 (en) 1996-04-25
BR9509329A (pt) 1997-10-14
DK0785948T3 (da) 2003-08-04
EP0804479B1 (en) 2006-10-11
AU3708395A (en) 1996-05-06
KR100278597B1 (ko) 2001-01-15
CA2202075C (en) 2003-12-09
WO1996011949A2 (en) 1996-04-25
PL319784A1 (en) 1997-08-18
FI971536A0 (fi) 1997-04-11
FI120040B (fi) 2009-06-15
BG101408A (en) 1997-12-30
CZ105097A3 (cs) 1998-10-14
EP0804479A1 (en) 1997-11-05
DE69530403D1 (de) 2003-05-22
SK43197A3 (en) 1999-03-12
PL320484A1 (en) 1997-09-29
WO1996011949A3 (en) 1996-12-12
NO318761B1 (no) 2005-05-02

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