NO317299B1 - Sulfonamidholdige indolforbindelser, deres anvendelse samt farmasoytiske preparater inneholdende disse - Google Patents
Sulfonamidholdige indolforbindelser, deres anvendelse samt farmasoytiske preparater inneholdende disse Download PDFInfo
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- NO317299B1 NO317299B1 NO20005357A NO20005357A NO317299B1 NO 317299 B1 NO317299 B1 NO 317299B1 NO 20005357 A NO20005357 A NO 20005357A NO 20005357 A NO20005357 A NO 20005357A NO 317299 B1 NO317299 B1 NO 317299B1
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- Prior art keywords
- group
- indol
- bromo
- hydrates
- methyl
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- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11049870A JP2000247949A (ja) | 1999-02-26 | 1999-02-26 | スルホンアミド含有インドール化合物 |
| PCT/JP2000/001071 WO2000050395A1 (fr) | 1999-02-26 | 2000-02-24 | Composes indoles contenant un sulfonamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20005357D0 NO20005357D0 (no) | 2000-10-24 |
| NO20005357L NO20005357L (no) | 2000-12-22 |
| NO317299B1 true NO317299B1 (no) | 2004-10-04 |
Family
ID=12843091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005357A NO317299B1 (no) | 1999-02-26 | 2000-10-24 | Sulfonamidholdige indolforbindelser, deres anvendelse samt farmasoytiske preparater inneholdende disse |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6469043B1 (zh) |
| EP (1) | EP1074542B1 (zh) |
| JP (3) | JP2000247949A (zh) |
| KR (1) | KR100627611B1 (zh) |
| CN (1) | CN1132814C (zh) |
| AT (1) | ATE325094T1 (zh) |
| AU (1) | AU766936B2 (zh) |
| CA (1) | CA2327253C (zh) |
| DE (1) | DE60027648T2 (zh) |
| DK (1) | DK1074542T3 (zh) |
| ES (1) | ES2259997T3 (zh) |
| HU (1) | HU228787B1 (zh) |
| NO (1) | NO317299B1 (zh) |
| NZ (1) | NZ507464A (zh) |
| PT (1) | PT1074542E (zh) |
| RU (1) | RU2208607C2 (zh) |
| WO (1) | WO2000050395A1 (zh) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040018192A1 (en) * | 2000-02-03 | 2004-01-29 | Toshiaki Wakabayashi | Integrin expression inhibitors |
| US6716879B2 (en) * | 2000-08-30 | 2004-04-06 | Compass Pharmaceuticals, Llc | Methods for anti-tumor therapy |
| TWI283575B (en) | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| JP4255285B2 (ja) * | 2001-02-21 | 2009-04-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | インテグリン発現抑制を介した血管新生抑制剤の効果を検定する方法 |
| CN1551766A (zh) * | 2001-09-05 | 2004-12-01 | ������������ʽ���� | 淋巴细胞活化抑制剂和自身免疫性疾病治疗剂 |
| WO2003022272A1 (fr) * | 2001-09-05 | 2003-03-20 | Eisai C0. Ltd. | Agents stimulant l'appetit et remedes contre l'anorexie |
| WO2003074045A1 (fr) * | 2002-03-05 | 2003-09-12 | Eisai Co., Ltd. | Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese |
| WO2004087672A1 (en) | 2003-03-28 | 2004-10-14 | Cornell Research Foundation, Inc. | Migrastatin analog compositions and uses thereof |
| WO2004091664A1 (ja) * | 2003-04-18 | 2004-10-28 | Eisai Co., Ltd. | 細胞質リンゴ酸脱水素酵素阻害剤 |
| PL1666463T3 (pl) * | 2003-09-10 | 2011-04-29 | Eisai R&D Man Co Ltd | Kryształ związku indolowego zawierającego sulfonamid i sposób jego wytwarzania |
| US20070037854A1 (en) * | 2003-09-10 | 2007-02-15 | Kenji Hayashi | Process for preparing sulfonamide-containing indole compounds |
| CA2541709C (en) * | 2003-11-13 | 2013-06-04 | California Pacific Medical Center | Anti-pecam therapy for metastasis suppression |
| WO2006001967A2 (en) * | 2004-05-25 | 2006-01-05 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs in the treatment of cancer |
| EP2364699A1 (en) | 2004-09-13 | 2011-09-14 | Eisai R&D Management Co., Ltd. | Joint use of sulfonamide based compound with angiogenesis inhibitor |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| US8188141B2 (en) * | 2004-09-23 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Isomigrastatin analogs in the treatment of cancer |
| PT1859793E (pt) | 2005-02-28 | 2011-07-05 | Eisai R&D Man Co Ltd | Uso combinado inovador de um composto de sulfonamida no tratamento oncológico |
| EP2308839B1 (en) * | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| AU2006318212C1 (en) * | 2005-11-23 | 2012-08-30 | The Board Of Regents Of The University Of Texas System | Oncogenic ras-specific cytotoxic compound and methods of use thereof |
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| WO2007086605A1 (ja) * | 2006-01-27 | 2007-08-02 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の効果を予測する方法 |
| US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
| DE102007012284A1 (de) * | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
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| EP2817292B1 (en) | 2012-02-22 | 2019-12-18 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as tnap inhibitors |
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| JP2021511290A (ja) * | 2018-01-25 | 2021-05-06 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | タンパク質分解のためのスルホンアミド誘導体 |
| EP3953331A4 (en) * | 2019-04-10 | 2022-12-28 | Peloton Therapeutics, Inc. | PYRAZOLESULFONAMIDES AS ANTITUMORS |
| US20240092770A1 (en) * | 2022-08-15 | 2024-03-21 | Recursion Pharmaceuticals, Inc. | Heterocycle RMB39 Modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9115160D0 (en) * | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
| NZ273073A (en) | 1993-09-10 | 1996-09-25 | Eisai Co Ltd | Bicyclic heterocyclic sulphonamide and sulphonic acid ester derivatives and pharmaceutical compositions thereof |
| JP3545461B2 (ja) * | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| JP3690831B2 (ja) | 1995-02-27 | 2005-08-31 | エーザイ株式会社 | インドール含有スルホンアミド誘導体 |
| WO1997030706A1 (fr) | 1996-02-26 | 1997-08-28 | Eisai Co., Ltd. | Compositions contenant un agent antitumoral |
| JP3868534B2 (ja) | 1996-05-24 | 2007-01-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド誘導体の製造法および中間体 |
| US20040018192A1 (en) | 2000-02-03 | 2004-01-29 | Toshiaki Wakabayashi | Integrin expression inhibitors |
-
1999
- 1999-02-26 JP JP11049870A patent/JP2000247949A/ja active Pending
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2000
- 2000-02-24 NZ NZ507464A patent/NZ507464A/en not_active IP Right Cessation
- 2000-02-24 RU RU2000129508/04A patent/RU2208607C2/ru not_active IP Right Cessation
- 2000-02-24 US US09/647,215 patent/US6469043B1/en not_active Expired - Lifetime
- 2000-02-24 AU AU26916/00A patent/AU766936B2/en not_active Ceased
- 2000-02-24 PT PT00905321T patent/PT1074542E/pt unknown
- 2000-02-24 AT AT00905321T patent/ATE325094T1/de active
- 2000-02-24 EP EP00905321A patent/EP1074542B1/en not_active Expired - Lifetime
- 2000-02-24 KR KR1020007011026A patent/KR100627611B1/ko not_active IP Right Cessation
- 2000-02-24 HU HU0101434A patent/HU228787B1/hu not_active IP Right Cessation
- 2000-02-24 JP JP2000600978A patent/JP3866041B2/ja not_active Expired - Fee Related
- 2000-02-24 ES ES00905321T patent/ES2259997T3/es not_active Expired - Lifetime
- 2000-02-24 DE DE60027648T patent/DE60027648T2/de not_active Expired - Lifetime
- 2000-02-24 DK DK00905321T patent/DK1074542T3/da active
- 2000-02-24 WO PCT/JP2000/001071 patent/WO2000050395A1/ja active IP Right Grant
- 2000-02-24 CN CN008002290A patent/CN1132814C/zh not_active Expired - Fee Related
- 2000-02-24 CA CA002327253A patent/CA2327253C/en not_active Expired - Fee Related
- 2000-10-24 NO NO20005357A patent/NO317299B1/no not_active IP Right Cessation
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2002
- 2002-03-18 US US10/098,420 patent/US6673787B2/en not_active Expired - Lifetime
- 2002-03-18 US US10/098,421 patent/US6638964B2/en not_active Expired - Lifetime
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2010
- 2010-04-02 JP JP2010085696A patent/JP2010180229A/ja active Pending
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|---|---|
| DE60027648T2 (de) | 2007-04-05 |
| KR100627611B1 (ko) | 2006-09-25 |
| EP1074542A1 (en) | 2001-02-07 |
| CA2327253C (en) | 2007-10-16 |
| CN1294579A (zh) | 2001-05-09 |
| KR20010042434A (ko) | 2001-05-25 |
| RU2208607C2 (ru) | 2003-07-20 |
| AU766936B2 (en) | 2003-10-23 |
| AU2691600A (en) | 2000-09-14 |
| ES2259997T3 (es) | 2006-11-01 |
| HUP0101434A2 (hu) | 2001-09-28 |
| NO20005357D0 (no) | 2000-10-24 |
| JP2010180229A (ja) | 2010-08-19 |
| EP1074542A4 (en) | 2002-02-06 |
| HUP0101434A3 (en) | 2001-10-29 |
| US20020128480A1 (en) | 2002-09-12 |
| US6673787B2 (en) | 2004-01-06 |
| JP3866041B2 (ja) | 2007-01-10 |
| ATE325094T1 (de) | 2006-06-15 |
| DE60027648D1 (de) | 2006-06-08 |
| US20020128483A1 (en) | 2002-09-12 |
| DK1074542T3 (da) | 2006-08-14 |
| CN1132814C (zh) | 2003-12-31 |
| JP2000247949A (ja) | 2000-09-12 |
| NZ507464A (en) | 2003-10-31 |
| CA2327253A1 (en) | 2000-08-31 |
| US6469043B1 (en) | 2002-10-22 |
| US6638964B2 (en) | 2003-10-28 |
| EP1074542B1 (en) | 2006-05-03 |
| PT1074542E (pt) | 2006-07-31 |
| WO2000050395A1 (fr) | 2000-08-31 |
| NO20005357L (no) | 2000-12-22 |
| HU228787B1 (en) | 2013-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ERR | Erratum |
Free format text: SULFONAMIDHOLDIGE INDOLFORBINDELSER, DERES ANVENDELSE SAMT FARMASOYTISKE PREPARATER INNEHOLDENDE DISSE |
|
| MM1K | Lapsed by not paying the annual fees |