NO20005357L - Sulfonamidholdige indolforbindelser - Google Patents

Sulfonamidholdige indolforbindelser

Info

Publication number
NO20005357L
NO20005357L NO20005357A NO20005357A NO20005357L NO 20005357 L NO20005357 L NO 20005357L NO 20005357 A NO20005357 A NO 20005357A NO 20005357 A NO20005357 A NO 20005357A NO 20005357 L NO20005357 L NO 20005357L
Authority
NO
Norway
Prior art keywords
hydrogen
ring
represents hydrogen
indole compounds
cyanophenyl
Prior art date
Application number
NO20005357A
Other languages
English (en)
Other versions
NO20005357D0 (no
NO317299B1 (no
Inventor
Toru Haneda
Akihiko Tsuruoka
Jun-Ichi Kamata
Tadashi Okabe
Keiko Takahashi
Kazumasa Nara
Shinichi Hamaoka
Norihiro Ueda
Takashi Owa
Toshiaki Wakabayashi
Yasuhiro Funahashi
Taro Semba
Naoko Hata
Yuji Yamamoto
Yoichi Ozawa
Naoko Tsukahara
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO20005357D0 publication Critical patent/NO20005357D0/no
Publication of NO20005357L publication Critical patent/NO20005357L/no
Publication of NO317299B1 publication Critical patent/NO317299B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20005357A 1999-02-26 2000-10-24 Sulfonamidholdige indolforbindelser, deres anvendelse samt farmasoytiske preparater inneholdende disse NO317299B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11049870A JP2000247949A (ja) 1999-02-26 1999-02-26 スルホンアミド含有インドール化合物
PCT/JP2000/001071 WO2000050395A1 (fr) 1999-02-26 2000-02-24 Composes indoles contenant un sulfonamide

Publications (3)

Publication Number Publication Date
NO20005357D0 NO20005357D0 (no) 2000-10-24
NO20005357L true NO20005357L (no) 2000-12-22
NO317299B1 NO317299B1 (no) 2004-10-04

Family

ID=12843091

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005357A NO317299B1 (no) 1999-02-26 2000-10-24 Sulfonamidholdige indolforbindelser, deres anvendelse samt farmasoytiske preparater inneholdende disse

Country Status (17)

Country Link
US (3) US6469043B1 (no)
EP (1) EP1074542B1 (no)
JP (3) JP2000247949A (no)
KR (1) KR100627611B1 (no)
CN (1) CN1132814C (no)
AT (1) ATE325094T1 (no)
AU (1) AU766936B2 (no)
CA (1) CA2327253C (no)
DE (1) DE60027648T2 (no)
DK (1) DK1074542T3 (no)
ES (1) ES2259997T3 (no)
HU (1) HU228787B1 (no)
NO (1) NO317299B1 (no)
NZ (1) NZ507464A (no)
PT (1) PT1074542E (no)
RU (1) RU2208607C2 (no)
WO (1) WO2000050395A1 (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018192A1 (en) * 2000-02-03 2004-01-29 Toshiaki Wakabayashi Integrin expression inhibitors
US6716879B2 (en) * 2000-08-30 2004-04-06 Compass Pharmaceuticals, Llc Methods for anti-tumor therapy
TWI283575B (en) 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
JP4255285B2 (ja) * 2001-02-21 2009-04-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 インテグリン発現抑制を介した血管新生抑制剤の効果を検定する方法
CN1551766A (zh) * 2001-09-05 2004-12-01 ������������ʽ���� 淋巴细胞活化抑制剂和自身免疫性疾病治疗剂
WO2003022272A1 (fr) * 2001-09-05 2003-03-20 Eisai C0. Ltd. Agents stimulant l'appetit et remedes contre l'anorexie
WO2003074045A1 (fr) * 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
WO2004087672A1 (en) 2003-03-28 2004-10-14 Cornell Research Foundation, Inc. Migrastatin analog compositions and uses thereof
WO2004091664A1 (ja) * 2003-04-18 2004-10-28 Eisai Co., Ltd. 細胞質リンゴ酸脱水素酵素阻害剤
PL1666463T3 (pl) * 2003-09-10 2011-04-29 Eisai R&D Man Co Ltd Kryształ związku indolowego zawierającego sulfonamid i sposób jego wytwarzania
US20070037854A1 (en) * 2003-09-10 2007-02-15 Kenji Hayashi Process for preparing sulfonamide-containing indole compounds
CA2541709C (en) * 2003-11-13 2013-06-04 California Pacific Medical Center Anti-pecam therapy for metastasis suppression
WO2006001967A2 (en) * 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
EP2364699A1 (en) 2004-09-13 2011-09-14 Eisai R&D Management Co., Ltd. Joint use of sulfonamide based compound with angiogenesis inhibitor
US8772269B2 (en) * 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
US8188141B2 (en) * 2004-09-23 2012-05-29 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
PT1859793E (pt) 2005-02-28 2011-07-05 Eisai R&D Man Co Ltd Uso combinado inovador de um composto de sulfonamida no tratamento oncológico
EP2308839B1 (en) * 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
AU2006318212C1 (en) * 2005-11-23 2012-08-30 The Board Of Regents Of The University Of Texas System Oncogenic ras-specific cytotoxic compound and methods of use thereof
US7625896B2 (en) * 2005-11-25 2009-12-01 Hoffman-La Roche Inc. Pyridylsulfonamide derivatives
WO2007086605A1 (ja) * 2006-01-27 2007-08-02 Eisai R & D Management Co., Ltd. スルホンアミド化合物の効果を予測する方法
US20100291592A1 (en) 2006-04-20 2010-11-18 Taro Semba Novel marker for sensitivity against sulfonamide compound
DE102007012284A1 (de) * 2007-03-16 2008-09-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035333A1 (de) 2007-07-27 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035334A1 (de) 2007-07-27 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007042154A1 (de) 2007-09-05 2009-03-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
US20090142832A1 (en) * 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
JP2012136435A (ja) * 2009-03-30 2012-07-19 Eisai R & D Management Co Ltd 腫瘍組織の感受性を検査する方法
EP2817292B1 (en) 2012-02-22 2019-12-18 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as tnap inhibitors
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
WO2019102488A1 (en) * 2017-11-27 2019-05-31 Council Of Scientific & Industrial Research Indole (sulfomyl) n-hydroxy benzamide derivatives as selective hdac inhibitors
JP2021511290A (ja) * 2018-01-25 2021-05-06 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド タンパク質分解のためのスルホンアミド誘導体
EP3953331A4 (en) * 2019-04-10 2022-12-28 Peloton Therapeutics, Inc. PYRAZOLESULFONAMIDES AS ANTITUMORS
US20240092770A1 (en) * 2022-08-15 2024-03-21 Recursion Pharmaceuticals, Inc. Heterocycle RMB39 Modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9115160D0 (en) * 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
NZ273073A (en) 1993-09-10 1996-09-25 Eisai Co Ltd Bicyclic heterocyclic sulphonamide and sulphonic acid ester derivatives and pharmaceutical compositions thereof
JP3545461B2 (ja) * 1993-09-10 2004-07-21 エーザイ株式会社 二環式ヘテロ環含有スルホンアミド誘導体
JP3690831B2 (ja) 1995-02-27 2005-08-31 エーザイ株式会社 インドール含有スルホンアミド誘導体
WO1997030706A1 (fr) 1996-02-26 1997-08-28 Eisai Co., Ltd. Compositions contenant un agent antitumoral
JP3868534B2 (ja) 1996-05-24 2007-01-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド誘導体の製造法および中間体
US20040018192A1 (en) 2000-02-03 2004-01-29 Toshiaki Wakabayashi Integrin expression inhibitors

Also Published As

Publication number Publication date
DE60027648T2 (de) 2007-04-05
KR100627611B1 (ko) 2006-09-25
EP1074542A1 (en) 2001-02-07
CA2327253C (en) 2007-10-16
CN1294579A (zh) 2001-05-09
KR20010042434A (ko) 2001-05-25
RU2208607C2 (ru) 2003-07-20
AU766936B2 (en) 2003-10-23
AU2691600A (en) 2000-09-14
ES2259997T3 (es) 2006-11-01
HUP0101434A2 (hu) 2001-09-28
NO20005357D0 (no) 2000-10-24
JP2010180229A (ja) 2010-08-19
EP1074542A4 (en) 2002-02-06
HUP0101434A3 (en) 2001-10-29
US20020128480A1 (en) 2002-09-12
US6673787B2 (en) 2004-01-06
JP3866041B2 (ja) 2007-01-10
ATE325094T1 (de) 2006-06-15
DE60027648D1 (de) 2006-06-08
US20020128483A1 (en) 2002-09-12
DK1074542T3 (da) 2006-08-14
CN1132814C (zh) 2003-12-31
JP2000247949A (ja) 2000-09-12
NZ507464A (en) 2003-10-31
CA2327253A1 (en) 2000-08-31
US6469043B1 (en) 2002-10-22
US6638964B2 (en) 2003-10-28
EP1074542B1 (en) 2006-05-03
NO317299B1 (no) 2004-10-04
PT1074542E (pt) 2006-07-31
WO2000050395A1 (fr) 2000-08-31
HU228787B1 (en) 2013-05-28

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Legal Events

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Free format text: SULFONAMIDHOLDIGE INDOLFORBINDELSER, DERES ANVENDELSE SAMT FARMASOYTISKE PREPARATER INNEHOLDENDE DISSE

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