NO316662B1 - Intrabukkalt opploselig, presstopt produkter og fremgangsmate for fremstilling dette - Google Patents
Intrabukkalt opploselig, presstopt produkter og fremgangsmate for fremstilling dette Download PDFInfo
- Publication number
- NO316662B1 NO316662B1 NO19963180A NO963180A NO316662B1 NO 316662 B1 NO316662 B1 NO 316662B1 NO 19963180 A NO19963180 A NO 19963180A NO 963180 A NO963180 A NO 963180A NO 316662 B1 NO316662 B1 NO 316662B1
- Authority
- NO
- Norway
- Prior art keywords
- saccharide
- castability
- hardness
- low
- pressure
- Prior art date
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- 229960003287 roxatidine acetate Drugs 0.000 description 1
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- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
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- 229960002959 sincalide Drugs 0.000 description 1
- 229940125706 skeletal muscle relaxant agent Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 229940084026 sodium valproate Drugs 0.000 description 1
- KSRLIXGNPXAZHD-HAZZGOGXSA-M sodium;3-[(e)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-5-oxo-4h-imidazol-2-olate Chemical compound [Na+].[O-]C1=NC(=O)CN1\N=C\C1=CC=C(C=2C=CC(=CC=2)[N+]([O-])=O)O1 KSRLIXGNPXAZHD-HAZZGOGXSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
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- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
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- 229960005344 tiapride Drugs 0.000 description 1
- 229960000488 tizanidine Drugs 0.000 description 1
- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- 229960004813 trichlormethiazide Drugs 0.000 description 1
- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
- GPMXUUPHFNMNDH-UHFFFAOYSA-N trifluperidol Chemical compound C1CC(O)(C=2C=C(C=CC=2)C(F)(F)F)CCN1CCCC(=O)C1=CC=C(F)C=C1 GPMXUUPHFNMNDH-UHFFFAOYSA-N 0.000 description 1
- 229960002341 trifluperidol Drugs 0.000 description 1
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- 239000002492 water-soluble polymer binding agent Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- JDJALSWDQPEHEJ-LMVCGNDWSA-N x4853 Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 JDJALSWDQPEHEJ-LMVCGNDWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1011294 | 1994-01-31 | ||
JP8665294 | 1994-04-25 | ||
PCT/JP1995/000102 WO1995020380A1 (fr) | 1994-01-31 | 1995-01-27 | Moulage comprime a solubilite intra-orale et son procede de production |
Publications (3)
Publication Number | Publication Date |
---|---|
NO963180D0 NO963180D0 (no) | 1996-07-30 |
NO963180L NO963180L (no) | 1996-09-30 |
NO316662B1 true NO316662B1 (no) | 2004-03-22 |
Family
ID=26345308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19963180A NO316662B1 (no) | 1994-01-31 | 1996-07-30 | Intrabukkalt opploselig, presstopt produkter og fremgangsmate for fremstilling dette |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0745382B1 (zh) |
JP (1) | JP3122141B2 (zh) |
KR (1) | KR100386391B1 (zh) |
CN (1) | CN1182838C (zh) |
AT (1) | ATE253899T1 (zh) |
AU (1) | AU699715B2 (zh) |
CA (1) | CA2179382C (zh) |
DE (1) | DE69532110T2 (zh) |
DK (1) | DK0745382T3 (zh) |
ES (1) | ES2210280T3 (zh) |
FI (1) | FI120817B (zh) |
HU (1) | HUT74908A (zh) |
MX (1) | MX9603035A (zh) |
NO (1) | NO316662B1 (zh) |
NZ (1) | NZ278678A (zh) |
PH (1) | PH31467A (zh) |
PL (1) | PL187160B1 (zh) |
PT (1) | PT745382E (zh) |
RU (1) | RU2147227C1 (zh) |
TW (1) | TW391880B (zh) |
WO (1) | WO1995020380A1 (zh) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958453A (en) | 1996-10-31 | 1999-09-28 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility |
US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
TW580397B (en) | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
US6328994B1 (en) | 1998-05-18 | 2001-12-11 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
WO2000003735A1 (fr) | 1998-07-15 | 2000-01-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Excipient |
EP1561458B1 (en) | 1998-07-28 | 2010-09-15 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
DE60020680T2 (de) * | 1999-02-17 | 2006-05-04 | Kyowa Hakko Kogyo Co., Ltd. | Tabletten und verfahren zur tablettenherstellung |
FR2790387B1 (fr) * | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
GB9910505D0 (en) * | 1999-05-06 | 1999-07-07 | Electrosols Ltd | A method and apparatus for manufacturing consumable tablets |
US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
JP3415835B2 (ja) * | 2000-06-30 | 2003-06-09 | 山之内製薬株式会社 | 口腔内速崩壊錠およびその製造法 |
CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
JP2002087965A (ja) * | 2000-09-14 | 2002-03-27 | Lion Corp | 口中崩壊性アスピリン含有錠剤 |
CN100335040C (zh) * | 2000-12-07 | 2007-09-05 | 奥坦纳医药公司 | 含有酸敏感型活性成分的快速崩解片剂 |
US6998139B2 (en) * | 2001-03-15 | 2006-02-14 | Astellas Pharma Inc. | Bitterness-reduced intrabuccally quick disintegrating tablets and method for reducing bitterness |
US6872405B2 (en) | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
US7255876B2 (en) * | 2001-07-27 | 2007-08-14 | Astellas Pharma, Inc. | Composition comprises sustained-release fine particles and manufacturing method thereof |
CN1284532C (zh) * | 2001-09-28 | 2006-11-15 | 株式会社三和化学研究所 | 有核型速溶崩解性成型品 |
FR2831820B1 (fr) * | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
EP1446088A2 (en) * | 2001-11-07 | 2004-08-18 | Pharmacia Corporation | Intraorally disintegrating valdecoxib compositions prepared by fluid bed granulation process |
FR2834894B1 (fr) * | 2002-01-21 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de piribedil |
FR2834897B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de testosterone |
FR2834896B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'ivabradine |
FR2834890B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'agomelatine |
FR2834891B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de 2-({2-methoxy-2-[3(trifluoromethyl)phenyl]ethyl}amino)ethyl4 -(2-(9h-fluoren-9-yl)acetyl]amino}ethyl)benzoate |
FR2834892B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de mitiglinide |
FR2834893B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de perindopril |
AU2003259336A1 (en) * | 2002-08-21 | 2004-03-11 | Phoqus Pharmaceuticals Limited | Use of an aqueous solution of citric acid and a water-soluble sugar like lactitol as granulation liquid in the manufacture of tablets |
JPWO2004066991A1 (ja) * | 2003-01-27 | 2006-05-18 | アステラス製薬株式会社 | タムスロシンまたはその塩の腸溶性徐放微粒子およびその製造法 |
US7749533B2 (en) * | 2003-05-07 | 2010-07-06 | Akina, Inc. | Highly plastic granules for making fast melting tablets |
US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
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-
1995
- 1995-01-27 CA CA002179382A patent/CA2179382C/en not_active Expired - Fee Related
- 1995-01-27 AT AT95906533T patent/ATE253899T1/de active
- 1995-01-27 JP JP07519980A patent/JP3122141B2/ja not_active Expired - Lifetime
- 1995-01-27 CN CNB951914081A patent/CN1182838C/zh not_active Expired - Lifetime
- 1995-01-27 DK DK95906533T patent/DK0745382T3/da active
- 1995-01-27 PT PT95906533T patent/PT745382E/pt unknown
- 1995-01-27 TW TW084100735A patent/TW391880B/zh not_active IP Right Cessation
- 1995-01-27 HU HU9602083A patent/HUT74908A/hu not_active Application Discontinuation
- 1995-01-27 NZ NZ278678A patent/NZ278678A/en not_active IP Right Cessation
- 1995-01-27 ES ES95906533T patent/ES2210280T3/es not_active Expired - Lifetime
- 1995-01-27 PL PL95315552A patent/PL187160B1/pl not_active IP Right Cessation
- 1995-01-27 DE DE69532110T patent/DE69532110T2/de not_active Expired - Lifetime
- 1995-01-27 RU RU96117252/14A patent/RU2147227C1/ru not_active IP Right Cessation
- 1995-01-27 AU AU14671/95A patent/AU699715B2/en not_active Ceased
- 1995-01-27 KR KR1019960704132A patent/KR100386391B1/ko not_active IP Right Cessation
- 1995-01-27 EP EP95906533A patent/EP0745382B1/en not_active Expired - Lifetime
- 1995-01-27 PH PH49851A patent/PH31467A/en unknown
- 1995-01-27 MX MX9603035A patent/MX9603035A/es unknown
- 1995-01-27 WO PCT/JP1995/000102 patent/WO1995020380A1/ja active IP Right Grant
-
1996
- 1996-07-30 NO NO19963180A patent/NO316662B1/no not_active IP Right Cessation
- 1996-07-31 FI FI963022A patent/FI120817B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0745382A1 (en) | 1996-12-04 |
ES2210280T3 (es) | 2004-07-01 |
HUT74908A (en) | 1997-03-28 |
DE69532110T2 (de) | 2004-09-09 |
CN1139878A (zh) | 1997-01-08 |
PL315552A1 (en) | 1996-11-12 |
CN1182838C (zh) | 2005-01-05 |
NZ278678A (en) | 1998-03-25 |
EP0745382B1 (en) | 2003-11-12 |
HU9602083D0 (en) | 1996-09-30 |
EP0745382A4 (en) | 1997-10-29 |
TW391880B (en) | 2000-06-01 |
MX9603035A (es) | 1997-05-31 |
CA2179382C (en) | 2009-11-10 |
NO963180L (no) | 1996-09-30 |
PT745382E (pt) | 2004-04-30 |
AU1467195A (en) | 1995-08-15 |
FI963022A (fi) | 1996-07-31 |
DE69532110D1 (de) | 2003-12-18 |
RU2147227C1 (ru) | 2000-04-10 |
FI120817B (fi) | 2010-03-31 |
KR100386391B1 (ko) | 2003-08-30 |
DK0745382T3 (da) | 2004-03-22 |
PL187160B1 (pl) | 2004-05-31 |
JP3122141B2 (ja) | 2001-01-09 |
FI963022A0 (fi) | 1996-07-31 |
WO1995020380A1 (fr) | 1995-08-03 |
ATE253899T1 (de) | 2003-11-15 |
AU699715B2 (en) | 1998-12-10 |
NO963180D0 (no) | 1996-07-30 |
PH31467A (en) | 1998-11-03 |
CA2179382A1 (en) | 1995-08-03 |
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