NO315379B1 - Isolert DNA-molekyl, hybridvektor, Aspergillus niger-stamme, Aspergillus niger-serin protease, fremgangsmåte for fremstilling av et önsketpolypeptid samtvert transformert med en hybrid ekspresjonvektor - Google Patents

Isolert DNA-molekyl, hybridvektor, Aspergillus niger-stamme, Aspergillus niger-serin protease, fremgangsmåte for fremstilling av et önsketpolypeptid samtvert transformert med en hybrid ekspresjonvektor Download PDF

Info

Publication number
NO315379B1
NO315379B1 NO19931368A NO931368A NO315379B1 NO 315379 B1 NO315379 B1 NO 315379B1 NO 19931368 A NO19931368 A NO 19931368A NO 931368 A NO931368 A NO 931368A NO 315379 B1 NO315379 B1 NO 315379B1
Authority
NO
Norway
Prior art keywords
dna
aspergillus
ala
gene
ser
Prior art date
Application number
NO19931368A
Other languages
English (en)
Norwegian (no)
Other versions
NO931368L (no
NO931368D0 (no
Inventor
Frank Buxton
Albert Hinnen
Jacob Visser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939305097A external-priority patent/GB9305097D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO931368D0 publication Critical patent/NO931368D0/no
Publication of NO931368L publication Critical patent/NO931368L/no
Publication of NO315379B1 publication Critical patent/NO315379B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19931368A 1992-04-15 1993-04-14 Isolert DNA-molekyl, hybridvektor, Aspergillus niger-stamme, Aspergillus niger-serin protease, fremgangsmåte for fremstilling av et önsketpolypeptid samtvert transformert med en hybrid ekspresjonvektor NO315379B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810281 1992-04-15
GB939305097A GB9305097D0 (en) 1993-03-12 1993-03-12 Noval fungal protease

Publications (3)

Publication Number Publication Date
NO931368D0 NO931368D0 (no) 1993-04-14
NO931368L NO931368L (no) 1993-10-18
NO315379B1 true NO315379B1 (no) 2003-08-25

Family

ID=26132501

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19931368A NO315379B1 (no) 1992-04-15 1993-04-14 Isolert DNA-molekyl, hybridvektor, Aspergillus niger-stamme, Aspergillus niger-serin protease, fremgangsmåte for fremstilling av et önsketpolypeptid samtvert transformert med en hybrid ekspresjonvektor

Country Status (17)

Country Link
EP (1) EP0574347B1 (pt)
JP (2) JP3424840B2 (pt)
KR (1) KR100270644B1 (pt)
AT (1) ATE252156T1 (pt)
AU (1) AU663173B2 (pt)
CA (1) CA2093950C (pt)
CY (1) CY2507B1 (pt)
DE (1) DE69333249T2 (pt)
DK (1) DK0574347T3 (pt)
ES (1) ES2208637T3 (pt)
FI (1) FI112667B (pt)
HU (1) HU219809B (pt)
IL (2) IL105383A0 (pt)
MX (1) MX9302202A (pt)
NO (1) NO315379B1 (pt)
NZ (1) NZ247397A (pt)
PT (1) PT574347E (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821350A (en) * 1995-11-01 1998-10-13 Nexia Biotechnologies, Inc. Aspergillus niger beta-galactosidase gene
AU1092897A (en) * 1995-12-15 1997-07-14 Novo Nordisk A/S A funguns wherein the area, pepc and/or pepe genes have been inactivated
AU2152897A (en) 1996-03-27 1997-10-17 Novo Nordisk A/S Alkaline protease deficient filamentous fungi
EP0907744A1 (en) * 1996-06-05 1999-04-14 Gist-Brocades B.V. Fungal metallo protease genes
JPH1016992A (ja) * 1996-07-04 1998-01-20 Toagosei Co Ltd 接着剤用容器
US6806062B1 (en) 1998-10-05 2004-10-19 Novozymes A/S Fungal transcriptional activator useful in methods for producing polypeptides
WO2001068864A1 (en) 2000-03-14 2001-09-20 Novozymes A/S Fungal transcriptional activator useful in methods for producing polypeptides
US7858360B2 (en) 2005-10-17 2010-12-28 Novozymes A/S Use of fungal mutants for expression of antibodies
WO2009071530A1 (en) 2007-12-06 2009-06-11 Novozymes A/S Fungal pepc inhibitor
WO2011075677A2 (en) 2009-12-18 2011-06-23 Novozymes, Inc. Methods for producing polypeptides in protease-deficient mutants of trichoderma
MD4186C1 (ro) * 2012-02-20 2013-06-30 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Tulpină de fungi Fusarium gibbosum - producătoare de proteaze acide şi neutre, xilanaze şi b-glucozidaze
DK3019602T3 (en) 2013-07-10 2018-11-12 Glykos Finland Oy MULTIPLE PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF
DK3036324T3 (en) * 2013-08-23 2019-04-01 Novozymes As Regulated PepC expression
CA2954974A1 (en) 2014-07-21 2016-01-28 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1333777C (en) * 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi

Also Published As

Publication number Publication date
JPH0646863A (ja) 1994-02-22
KR100270644B1 (ko) 2000-11-01
MX9302202A (es) 1994-04-29
CY2507B1 (en) 2005-12-23
HU9301087D0 (en) 1993-06-28
IL105383A0 (en) 1993-08-18
FI931634A0 (fi) 1993-04-08
AU3695993A (en) 1993-10-21
EP0574347B1 (en) 2003-10-15
NO931368L (no) 1993-10-18
PT574347E (pt) 2004-02-27
NO931368D0 (no) 1993-04-14
CA2093950C (en) 2006-05-09
ATE252156T1 (de) 2003-11-15
IL170763A (en) 2007-10-31
JP2003235591A (ja) 2003-08-26
KR930021783A (ko) 1993-11-23
EP0574347A3 (pt) 1994-04-13
AU663173B2 (en) 1995-09-28
HUT67800A (en) 1995-05-29
DE69333249T2 (de) 2004-07-29
DK0574347T3 (da) 2004-01-26
NZ247397A (en) 1995-08-28
ES2208637T3 (es) 2004-06-16
DE69333249D1 (de) 2003-11-20
JP3636455B2 (ja) 2005-04-06
JP3424840B2 (ja) 2003-07-07
EP0574347A2 (en) 1993-12-15
FI931634A (fi) 1993-10-16
CA2093950A1 (en) 1993-10-16
FI112667B (fi) 2003-12-31
HU219809B (hu) 2001-08-28

Similar Documents

Publication Publication Date Title
NO315379B1 (no) Isolert DNA-molekyl, hybridvektor, Aspergillus niger-stamme, Aspergillus niger-serin protease, fremgangsmåte for fremstilling av et önsketpolypeptid samtvert transformert med en hybrid ekspresjonvektor
US5688663A (en) Gene encoding carboxypeptidase of Aspergillus niger
CA2134863C (en) Aspergillus niger aspartic protease
NO179078B (no) Replikerbar ekspresjonsvektor, anvendelse derav og transformert vert
US5846802A (en) Fungal Protease
NO302899B1 (no) Rekombinant DNA-molekyl, transformert vertscelle, anvendelse av rekombinant DNA-molekyl og hybridvektor, og pektinlyasene PLA, PLB, PLC, PLE eller PLF i ren form
JP3576549B2 (ja) 真核生物発現系
EP0439997B1 (en) Novel fungal expression system
US7001751B1 (en) PyrF gene and the utilization thereof
AU696369B2 (en) Genes encoding signal recognition particle of aspergillus niger
JP2000125859A (ja) 新規な選択マーカー遺伝子ならびにリゾムコール・プシルスの形質転換系

Legal Events

Date Code Title Description
MK1K Patent expired