NO314997B1 - Nye tiofenforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem - Google Patents
Nye tiofenforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem Download PDFInfo
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- NO314997B1 NO314997B1 NO19960706A NO960706A NO314997B1 NO 314997 B1 NO314997 B1 NO 314997B1 NO 19960706 A NO19960706 A NO 19960706A NO 960706 A NO960706 A NO 960706A NO 314997 B1 NO314997 B1 NO 314997B1
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- compound
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- methoxyphenyl
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- 150000003839 salts Chemical class 0.000 claims abstract description 11
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- 125000005843 halogen group Chemical group 0.000 claims abstract description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 77
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
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- 238000001727 in vivo Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-M leukotriene B4(1-) Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC([O-])=O VNYSSYRCGWBHLG-AMOLWHMGSA-M 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- HDZDGTPMZPFSAU-UHFFFAOYSA-N methyl 5-[4,5-bis(4-methoxyphenyl)thiophen-2-yl]-3,3-dimethylpentanoate Chemical compound S1C(CCC(C)(C)CC(=O)OC)=CC(C=2C=CC(OC)=CC=2)=C1C1=CC=C(OC)C=C1 HDZDGTPMZPFSAU-UHFFFAOYSA-N 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000003562 morphometric effect Effects 0.000 description 1
- 238000013425 morphometry Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- KERBAAIBDHEFDD-UHFFFAOYSA-N n-ethylformamide Chemical compound CCNC=O KERBAAIBDHEFDD-UHFFFAOYSA-N 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- FXLOVSHXALFLKQ-UHFFFAOYSA-N p-tolualdehyde Chemical compound CC1=CC=C(C=O)C=C1 FXLOVSHXALFLKQ-UHFFFAOYSA-N 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- GGUBFICZYGKNTD-UHFFFAOYSA-N triethyl phosphonoacetate Chemical compound CCOC(=O)CP(=O)(OCC)OCC GGUBFICZYGKNTD-UHFFFAOYSA-N 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9502061A FR2730996B1 (fr) | 1995-02-23 | 1995-02-23 | Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO960706D0 NO960706D0 (no) | 1996-02-22 |
| NO960706L NO960706L (no) | 1996-08-26 |
| NO314997B1 true NO314997B1 (no) | 2003-06-23 |
Family
ID=9476411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19960706A NO314997B1 (no) | 1995-02-23 | 1996-02-22 | Nye tiofenforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5705525A (xx) |
| EP (1) | EP0728755B1 (xx) |
| JP (1) | JPH08253470A (xx) |
| CN (1) | CN1058965C (xx) |
| AT (1) | ATE200488T1 (xx) |
| AU (1) | AU697832B2 (xx) |
| CA (1) | CA2170097C (xx) |
| CY (1) | CY2262B1 (xx) |
| DE (1) | DE69612416T2 (xx) |
| DK (1) | DK0728755T3 (xx) |
| ES (1) | ES2158255T3 (xx) |
| FI (1) | FI960795A (xx) |
| FR (1) | FR2730996B1 (xx) |
| GR (1) | GR3036192T3 (xx) |
| NO (1) | NO314997B1 (xx) |
| NZ (1) | NZ286045A (xx) |
| PT (1) | PT728755E (xx) |
| ZA (1) | ZA961472B (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1019399A1 (en) * | 1997-10-03 | 2000-07-19 | Merck Frosst Canada & Co. | Aryl thiophene derivatives as pde iv inhibitors |
| AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| FR2860792B1 (fr) * | 2003-10-10 | 2006-02-24 | Sanofi Synthelabo | Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique |
| KR20220100607A (ko) * | 2019-10-28 | 2022-07-15 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 5원 헤테로사이클릭 옥소카르복실산 화합물 및 이의 의약 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0055471A1 (en) * | 1980-12-29 | 1982-07-07 | E.I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines |
| GB8525716D0 (en) * | 1985-10-18 | 1985-11-20 | Roussel Lab Ltd | Chemical compounds |
| FR2655043B1 (fr) * | 1989-11-24 | 1992-02-07 | Adir | Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| US5571810A (en) * | 1990-06-11 | 1996-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Thiophene derivatives |
| GB9012936D0 (en) * | 1990-06-11 | 1990-08-01 | Fujisawa Pharmaceutical Co | Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
-
1995
- 1995-02-23 FR FR9502061A patent/FR2730996B1/fr not_active Expired - Fee Related
-
1996
- 1996-02-17 CN CN96106004A patent/CN1058965C/zh not_active Expired - Fee Related
- 1996-02-21 AU AU45675/96A patent/AU697832B2/en not_active Ceased
- 1996-02-21 FI FI960795A patent/FI960795A/fi not_active IP Right Cessation
- 1996-02-22 AT AT96400359T patent/ATE200488T1/de not_active IP Right Cessation
- 1996-02-22 DE DE69612416T patent/DE69612416T2/de not_active Expired - Fee Related
- 1996-02-22 DK DK96400359T patent/DK0728755T3/da active
- 1996-02-22 ES ES96400359T patent/ES2158255T3/es not_active Expired - Lifetime
- 1996-02-22 NO NO19960706A patent/NO314997B1/no unknown
- 1996-02-22 US US08/605,537 patent/US5705525A/en not_active Ceased
- 1996-02-22 NZ NZ286045A patent/NZ286045A/en unknown
- 1996-02-22 JP JP8035131A patent/JPH08253470A/ja active Pending
- 1996-02-22 CA CA002170097A patent/CA2170097C/fr not_active Expired - Fee Related
- 1996-02-22 EP EP96400359A patent/EP0728755B1/fr not_active Expired - Lifetime
- 1996-02-22 PT PT96400359T patent/PT728755E/pt unknown
- 1996-02-23 ZA ZA961472A patent/ZA961472B/xx unknown
-
1999
- 1999-08-03 US US09/368,343 patent/USRE37078E1/en not_active Expired - Fee Related
-
2001
- 2001-07-09 GR GR20010401040T patent/GR3036192T3/el not_active IP Right Cessation
-
2002
- 2002-03-27 CY CY0200012A patent/CY2262B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2730996A1 (fr) | 1996-08-30 |
| PT728755E (pt) | 2001-09-28 |
| EP0728755B1 (fr) | 2001-04-11 |
| ES2158255T3 (es) | 2001-09-01 |
| CY2262B1 (en) | 2003-07-04 |
| ATE200488T1 (de) | 2001-04-15 |
| DE69612416D1 (de) | 2001-05-17 |
| JPH08253470A (ja) | 1996-10-01 |
| GR3036192T3 (en) | 2001-10-31 |
| AU4567596A (en) | 1996-08-29 |
| CN1142496A (zh) | 1997-02-12 |
| CN1058965C (zh) | 2000-11-29 |
| US5705525A (en) | 1998-01-06 |
| CA2170097C (fr) | 2002-02-26 |
| DK0728755T3 (da) | 2001-07-30 |
| NO960706L (no) | 1996-08-26 |
| USRE37078E1 (en) | 2001-02-27 |
| NZ286045A (en) | 1996-10-28 |
| AU697832B2 (en) | 1998-10-15 |
| FI960795A (fi) | 1996-08-24 |
| ZA961472B (en) | 1996-08-28 |
| FR2730996B1 (fr) | 1997-06-20 |
| NO960706D0 (no) | 1996-02-22 |
| CA2170097A1 (fr) | 1996-08-24 |
| DE69612416T2 (de) | 2001-11-22 |
| FI960795A0 (fi) | 1996-02-21 |
| EP0728755A1 (fr) | 1996-08-28 |
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