ES2158255T3 - Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2158255T3
ES2158255T3 ES96400359T ES96400359T ES2158255T3 ES 2158255 T3 ES2158255 T3 ES 2158255T3 ES 96400359 T ES96400359 T ES 96400359T ES 96400359 T ES96400359 T ES 96400359T ES 2158255 T3 ES2158255 T3 ES 2158255T3
Authority
ES
Spain
Prior art keywords
thiophen
pharmaceutical compositions
compositions containing
preparation procedure
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96400359T
Other languages
English (en)
Inventor
Michel Wierzbicki
Frederic Sauveur
Jacqueline Bonnet
Charles Tordjman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2158255T3 publication Critical patent/ES2158255T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

NUEVOS COMPUESTOS DE TIOFENO DE FORMULA: EN LA QUE .X SUB,1}, X{SUB,2}, Y{SUB,1}, Y {SUB,2}, IDENTICOS O DIFERENTES, SON CADA UNO HIDROGENO O HALOGENO (C{SUB,1-5} ALQUILO O ALCOXI, O TRIFLUOROMETILO, R{SUB,1} ES HIDROGENO O C{SUB,1-5} ALQUILO, A ES UNA CADENA HIDROCARBONADA LINEAL DE C{SUB,1} A C{SUB,5} EN LA QUE CADA CARBONO ESTA EVENTUALMENTE MONO- O DI- SUSTITUIDO POR UN ALQUILO DE C{SUB,1} A C{SUB,5}, R{SUB,2} ES HIDROGENO, (C{SUB,1}-C{SUB,6}) ES ALQUILO, CICLOHEXILO O BENCILO; Y SUS SALES FISIOLOGICAMENTE TOLERABLES. LOS PRODUCTOS DE LA INVENCION PUEDEN UTILIZARSE EN TERAPIA PARTICULARMENTE COMO AGENTES ANTIINFLAMATORIOS.
ES96400359T 1995-02-23 1996-02-22 Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2158255T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502061A FR2730996B1 (fr) 1995-02-23 1995-02-23 Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2158255T3 true ES2158255T3 (es) 2001-09-01

Family

ID=9476411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96400359T Expired - Lifetime ES2158255T3 (es) 1995-02-23 1996-02-22 Nuevos derivados del tiofeno, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (18)

Country Link
US (2) US5705525A (es)
EP (1) EP0728755B1 (es)
JP (1) JPH08253470A (es)
CN (1) CN1058965C (es)
AT (1) ATE200488T1 (es)
AU (1) AU697832B2 (es)
CA (1) CA2170097C (es)
CY (1) CY2262B1 (es)
DE (1) DE69612416T2 (es)
DK (1) DK0728755T3 (es)
ES (1) ES2158255T3 (es)
FI (1) FI960795A (es)
FR (1) FR2730996B1 (es)
GR (1) GR3036192T3 (es)
NO (1) NO314997B1 (es)
NZ (1) NZ286045A (es)
PT (1) PT728755E (es)
ZA (1) ZA961472B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019399A1 (en) * 1997-10-03 2000-07-19 Merck Frosst Canada & Co. Aryl thiophene derivatives as pde iv inhibitors
AUPR283801A0 (en) * 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods
FR2860792B1 (fr) 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
MX2022005187A (es) * 2019-10-28 2022-07-27 Shanghai Inst Materia Medica Cas Compuesto de ácido oxocarboxílico heterocíclico de cinco miembros y el uso médico del mismo.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0055471A1 (en) * 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines
GB8525716D0 (en) * 1985-10-18 1985-11-20 Roussel Lab Ltd Chemical compounds
FR2655043B1 (fr) * 1989-11-24 1992-02-07 Adir Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
NO314997B1 (no) 2003-06-23
NZ286045A (en) 1996-10-28
FR2730996B1 (fr) 1997-06-20
NO960706L (no) 1996-08-26
ZA961472B (en) 1996-08-28
DK0728755T3 (da) 2001-07-30
US5705525A (en) 1998-01-06
USRE37078E1 (en) 2001-02-27
CA2170097A1 (fr) 1996-08-24
FI960795A (fi) 1996-08-24
CN1142496A (zh) 1997-02-12
DE69612416T2 (de) 2001-11-22
PT728755E (pt) 2001-09-28
AU4567596A (en) 1996-08-29
ATE200488T1 (de) 2001-04-15
EP0728755A1 (fr) 1996-08-28
DE69612416D1 (de) 2001-05-17
NO960706D0 (no) 1996-02-22
FI960795A0 (fi) 1996-02-21
CY2262B1 (en) 2003-07-04
CN1058965C (zh) 2000-11-29
GR3036192T3 (en) 2001-10-31
AU697832B2 (en) 1998-10-15
EP0728755B1 (fr) 2001-04-11
JPH08253470A (ja) 1996-10-01
CA2170097C (fr) 2002-02-26
FR2730996A1 (fr) 1996-08-30

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