AR005065A1 - Nuevos derivados fosfolipidos de acidos fosfonocarbonicos, medicamentos que lo contienen y utilizacion de los mismos. - Google Patents
Nuevos derivados fosfolipidos de acidos fosfonocarbonicos, medicamentos que lo contienen y utilizacion de los mismos.Info
- Publication number
- AR005065A1 AR005065A1 ARP960105662A ARP960105662A AR005065A1 AR 005065 A1 AR005065 A1 AR 005065A1 AR P960105662 A ARP960105662 A AR P960105662A AR P960105662 A ARP960105662 A AR P960105662A AR 005065 A1 AR005065 A1 AR 005065A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- phosphonocarbonic
- alkyl
- acids
- phospholipid derivatives
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000003904 phospholipids Chemical class 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 2
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- -1 phospholipid derivatives of phosphonocarbonic acids Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion se refiere a derivados fosfolipidos de acidos fosfonocarbonicos de la formula general (I), en donde: R1 en una agrupacion-(CH2)e - Cicl corresponde a una cadena alquileno con e igual a un numero entero, pudiendoes tar substituido uno de los atomos de carbono desde laposicion 3 por un heteroatomo; R2 puede ser hidrogeno o una cadena alquilo; R3 puede significar una cadena alquilo; X significa una linea de valencia,oxigeno, azufre, oxicarbonilo,carboniloxi, ca rbonilamido, amidocarbonilo, el grupo sulfinilo o sulfonilo; Y significa una linea de valencia, oxigeno,azufre, oxicarbonilo, carboniloxi, carbonilamido, amidocarbonilo, el grupo sulfinilo o sulfonilo; Cicl es un radicalalquilo ciclico, pudie ndo estarsubstituido el atomo de carbono del anillo por nitrogeno y los anillos saturados o aromaticos pueden estar substituidos una o varias veces porC1-C10-alquilo, C1-C10-alcoxi, C1-C10-alquilmercapto o halogeno; msignifica 0 y/o 1 a 3; con la condicion de que R1 puede ser igual a R2, cuando R2 tienesimultaneamente el significado de R1; sus tautomeros, isomeros opticos, racematos, sus sales fisiologicamente aceptables de bases inorganicas yorganicasy prodrogas de los compu estos de la formula general (I). Ademas se refiere a medicamentos que contienen a dichos compuestos y usos de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19547022A DE19547022A1 (de) | 1995-12-15 | 1995-12-15 | Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005065A1 true AR005065A1 (es) | 1999-04-07 |
Family
ID=7780310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105662A AR005065A1 (es) | 1995-12-15 | 1996-12-13 | Nuevos derivados fosfolipidos de acidos fosfonocarbonicos, medicamentos que lo contienen y utilizacion de los mismos. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5955452A (es) |
| EP (1) | EP0869817B1 (es) |
| JP (1) | JP2000505784A (es) |
| KR (1) | KR20000064375A (es) |
| CN (1) | CN1209069A (es) |
| AR (1) | AR005065A1 (es) |
| AT (1) | ATE219379T1 (es) |
| AU (1) | AU714922B2 (es) |
| BR (1) | BR9612137A (es) |
| CA (1) | CA2240365A1 (es) |
| CZ (1) | CZ292531B6 (es) |
| DE (2) | DE19547022A1 (es) |
| ES (1) | ES2179222T3 (es) |
| HU (1) | HUP0001524A3 (es) |
| IL (1) | IL124789A (es) |
| MX (1) | MX9804752A (es) |
| NO (1) | NO982755L (es) |
| NZ (1) | NZ325260A (es) |
| PL (1) | PL185115B1 (es) |
| RU (1) | RU2178418C2 (es) |
| SK (1) | SK282035B6 (es) |
| TR (1) | TR199801083T2 (es) |
| TW (1) | TW409128B (es) |
| WO (1) | WO1997022368A2 (es) |
| ZA (1) | ZA9610511B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW343975B (en) * | 1995-12-15 | 1998-11-01 | Boehringer Mannheim Gmbh | New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents |
| US6818057B2 (en) | 1999-03-02 | 2004-11-16 | Construction Research & Technology Gmbh | Retarder for calcium sulfoaluminate cements |
| US20040172288A1 (en) * | 2003-02-27 | 2004-09-02 | Korn Lawrence D. | Method for disseminating medical alert information |
| JP5752599B2 (ja) * | 2008-11-06 | 2015-07-22 | ヴァスキュラー バイオジェニックス リミテッド | 酸化脂質化合物およびその使用 |
| EP2876094A1 (en) | 2014-04-03 | 2015-05-27 | Basf Se | Cement and calcium sulphate based binder composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4150125A (en) * | 1977-09-30 | 1979-04-17 | Abbott Laboratories | Triglyceride ester of phosphonoacetic acid having antiviral activity |
| US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| DE4026265A1 (de) * | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
| TW343975B (en) * | 1995-12-15 | 1998-11-01 | Boehringer Mannheim Gmbh | New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents |
-
1995
- 1995-12-15 DE DE19547022A patent/DE19547022A1/de not_active Withdrawn
-
1996
- 1996-12-13 AR ARP960105662A patent/AR005065A1/es not_active Application Discontinuation
- 1996-12-13 ZA ZA9610511A patent/ZA9610511B/xx unknown
- 1996-12-14 TW TW085115474A patent/TW409128B/zh not_active IP Right Cessation
- 1996-12-16 AT AT96943973T patent/ATE219379T1/de not_active IP Right Cessation
- 1996-12-16 US US09/077,894 patent/US5955452A/en not_active Expired - Fee Related
- 1996-12-16 CN CN96180012A patent/CN1209069A/zh active Pending
- 1996-12-16 IL IL12478996A patent/IL124789A/en not_active IP Right Cessation
- 1996-12-16 KR KR1019980704353A patent/KR20000064375A/ko not_active Application Discontinuation
- 1996-12-16 TR TR1998/01083T patent/TR199801083T2/xx unknown
- 1996-12-16 NZ NZ325260A patent/NZ325260A/xx unknown
- 1996-12-16 WO PCT/EP1996/005648 patent/WO1997022368A2/de not_active Application Discontinuation
- 1996-12-16 ES ES96943973T patent/ES2179222T3/es not_active Expired - Lifetime
- 1996-12-16 SK SK755-98A patent/SK282035B6/sk unknown
- 1996-12-16 JP JP9522502A patent/JP2000505784A/ja not_active Ceased
- 1996-12-16 CZ CZ19981809A patent/CZ292531B6/cs not_active IP Right Cessation
- 1996-12-16 AU AU13731/97A patent/AU714922B2/en not_active Ceased
- 1996-12-16 RU RU98113307/04A patent/RU2178418C2/ru not_active IP Right Cessation
- 1996-12-16 DE DE59609377T patent/DE59609377D1/de not_active Expired - Fee Related
- 1996-12-16 BR BR9612137A patent/BR9612137A/pt not_active IP Right Cessation
- 1996-12-16 EP EP96943973A patent/EP0869817B1/de not_active Expired - Lifetime
- 1996-12-16 HU HU0001524A patent/HUP0001524A3/hu unknown
- 1996-12-16 PL PL96327138A patent/PL185115B1/pl not_active IP Right Cessation
- 1996-12-16 CA CA002240365A patent/CA2240365A1/en not_active Abandoned
-
1998
- 1998-06-12 MX MX9804752A patent/MX9804752A/es not_active IP Right Cessation
- 1998-06-15 NO NO982755A patent/NO982755L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE219379T1 (de) | 2002-07-15 |
| PL185115B1 (pl) | 2003-02-28 |
| ES2179222T3 (es) | 2003-01-16 |
| HUP0001524A2 (hu) | 2001-05-28 |
| CA2240365A1 (en) | 1997-06-26 |
| CZ292531B6 (cs) | 2003-10-15 |
| MX9804752A (es) | 1998-10-31 |
| CZ180998A3 (cs) | 1998-09-16 |
| EP0869817B1 (de) | 2002-06-19 |
| AU714922B2 (en) | 2000-01-13 |
| WO1997022368A2 (de) | 1997-06-26 |
| CN1209069A (zh) | 1999-02-24 |
| PL327138A1 (en) | 1998-11-23 |
| NZ325260A (en) | 1999-11-29 |
| TW409128B (en) | 2000-10-21 |
| SK75598A3 (en) | 1999-04-13 |
| ZA9610511B (en) | 1998-06-15 |
| DE19547022A1 (de) | 1997-06-19 |
| WO1997022368A3 (de) | 1997-10-23 |
| TR199801083T2 (xx) | 1998-10-21 |
| BR9612137A (pt) | 1999-07-13 |
| US5955452A (en) | 1999-09-21 |
| IL124789A (en) | 2002-03-10 |
| NO982755D0 (no) | 1998-06-15 |
| DE59609377D1 (de) | 2002-07-25 |
| SK282035B6 (sk) | 2001-10-08 |
| RU2178418C2 (ru) | 2002-01-20 |
| HUP0001524A3 (en) | 2001-05-28 |
| EP0869817A2 (de) | 1998-10-14 |
| AU1373197A (en) | 1997-07-14 |
| IL124789A0 (en) | 1999-01-26 |
| NO982755L (no) | 1998-08-14 |
| JP2000505784A (ja) | 2000-05-16 |
| KR20000064375A (ko) | 2000-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |