ES2136209T3 - Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres. - Google Patents

Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres.

Info

Publication number
ES2136209T3
ES2136209T3 ES94931977T ES94931977T ES2136209T3 ES 2136209 T3 ES2136209 T3 ES 2136209T3 ES 94931977 T ES94931977 T ES 94931977T ES 94931977 T ES94931977 T ES 94931977T ES 2136209 T3 ES2136209 T3 ES 2136209T3
Authority
ES
Spain
Prior art keywords
nitronyl
new
phenols
esterically
impaired
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931977T
Other languages
English (en)
Inventor
Edward G Janzen
Allan L Wilcox
Randall D Hinton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of ES2136209T3 publication Critical patent/ES2136209T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION ES EL USO DE FENOLES TRABADOS SUSTITUIDOS CON NITRONILO COMO ANTIOXIDANTES EN APLICACIONES TERAPEUTICAS. EN LA REALIZACION PREFERIDA, LAS COMPOSICIONES TIENEN LA FORMULA GENERAL (I), EN DONDE R{SUB,1} ES HIDROGENO, UN ALQUILO O UN ARILO Y R{SUB,2} ES UN ALQUILO O UN ARILO; R{SUB,3} ES UN ALQUILO; Y R{SUB,4} ES UN ALQUILO. ADEMAS, LA INVENCION SE REFIERE A NUEVAS COMPOSICIONES UTILES COMO ANTIOXIDANTES. LOS NUEVOS COMPUESTOS INCLUYEN: 2,6-DI-TERT-BUTIL-4-(N-TERT-OCTIL) NITRONILFENOL (DBONP); 2-6-DIMETIL-4-(N-TERT-OCTIL()) NITRONILFENOL (DMONP); (N-TERT-OCTIL)-C-FENILNITRONA (OPN).
ES94931977T 1993-10-22 1994-10-20 Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres. Expired - Lifetime ES2136209T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/141,241 US5455272A (en) 1993-10-22 1993-10-22 Spin trap nitronyl hindered phenols

Publications (1)

Publication Number Publication Date
ES2136209T3 true ES2136209T3 (es) 1999-11-16

Family

ID=22494820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931977T Expired - Lifetime ES2136209T3 (es) 1993-10-22 1994-10-20 Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres.

Country Status (6)

Country Link
US (4) US5455272A (es)
EP (1) EP0724565B1 (es)
AU (1) AU696451B2 (es)
DE (1) DE69420146T2 (es)
ES (1) ES2136209T3 (es)
WO (1) WO1995011227A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
JPH11512427A (ja) * 1995-09-11 1999-10-26 ヘキスト・マリオン・ルセル・インコーポレイテツド 環状ニトロンおよびこれらを含有する医薬組成物
EP0910370B1 (en) * 1996-04-23 2004-04-07 Centaur Pharmaceuticals, Inc. Compositions comprising a nitrone compound for use in treating uveitis
NZ333705A (en) 1996-07-19 2000-09-29 Centaur Pharmaceuticals Inc Furan nitrone derivatives and medicaments thereof
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
US5998469A (en) * 1998-01-16 1999-12-07 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
ATE228123T1 (de) * 1998-01-16 2002-12-15 Centaur Pharmaceuticals Inc Thiophennitronderivate
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
SI1077694T1 (en) * 1998-05-19 2004-10-31 Renovis, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
WO1999059579A1 (en) * 1998-05-19 1999-11-25 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2002520386A (ja) * 1998-07-17 2002-07-09 セントアー ファーマシューティカルズ インコーポレイテッド 炎症を処置するためのα−（２−ヒドロキシフェニル）ニトロン化合物、α−（２−ヒドロキシフェニル）ニトロン化合物を含む薬学的組成物およびそれらの使用
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
IT1312537B1 (it) * 1999-04-16 2002-04-22 Euphar Group Srl Derivati del (-)- verbenone.
AU2002253857A1 (en) * 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20050215646A1 (en) * 2004-03-09 2005-09-29 Renovis, Inc. Methods for treating multiple sclerosis and pharmaceutical compositions therefor
ES2367330T3 (es) * 2007-11-15 2011-11-02 Rohm And Haas Company Preparación de nitronas.
JP4996575B2 (ja) 2007-11-15 2012-08-08 ローム アンド ハース カンパニー ニトロンの製造
US9034926B2 (en) 2010-12-30 2015-05-19 Nicholas V. Perricone Topical nitrone spin trap compositions for psoriasis
US8986739B2 (en) 2011-02-28 2015-03-24 Nicholas V. Perricone Treatment of urinary incontinence using nitrone spin traps
JP6131265B2 (ja) * 2011-11-30 2017-05-17 ダウ グローバル テクノロジーズ エルエルシー ニトロン化合物とパーソナルケアにおけるその利用
JP6654142B2 (ja) 2014-03-07 2020-02-26 ダウ グローバル テクノロジーズ エルエルシー ニトロン化合物及びパーソナルケアにおけるその使用
US9730874B2 (en) 2014-05-12 2017-08-15 Dow Global Technologies Llc Nitrone compounds and their use in personal care
CN106471024B (zh) 2014-06-30 2019-06-04 陶氏环球技术有限责任公司 聚合硝酮及其在个人护理中的用途
WO2016154022A1 (en) * 2015-03-20 2016-09-29 Dow Global Technologies Llc Nitrone inhibition of oxidation of unsaturated fats
CN107427430B (zh) * 2015-03-20 2020-12-04 陶氏环球技术有限责任公司 不饱和脂肪氧化的硝酮抑制

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903049A (en) * 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
GB2137619A (en) * 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
JP2797559B2 (ja) * 1989-11-30 1998-09-17 住友化学工業株式会社 ニトロン化合物およびその製造法
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN

Also Published As

Publication number Publication date
AU696451B2 (en) 1998-09-10
US5527828A (en) 1996-06-18
AU8086994A (en) 1995-05-08
USRE36594E (en) 2000-02-29
US5455272A (en) 1995-10-03
WO1995011227A1 (en) 1995-04-27
DE69420146D1 (de) 1999-09-23
EP0724565A1 (en) 1996-08-07
DE69420146T2 (de) 2000-04-20
EP0724565B1 (en) 1999-08-18
US5532277A (en) 1996-07-02

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