ES2150663T3 - Tratamiento de la incontinencia urinaria utilizando (s)-oxibutinina y (s)-desetiloxibutinina. - Google Patents

Tratamiento de la incontinencia urinaria utilizando (s)-oxibutinina y (s)-desetiloxibutinina.

Info

Publication number
ES2150663T3
ES2150663T3 ES96906202T ES96906202T ES2150663T3 ES 2150663 T3 ES2150663 T3 ES 2150663T3 ES 96906202 T ES96906202 T ES 96906202T ES 96906202 T ES96906202 T ES 96906202T ES 2150663 T3 ES2150663 T3 ES 2150663T3
Authority
ES
Spain
Prior art keywords
desethylloxibutinine
oxybutinine
urinary incontinence
treatment
refers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96906202T
Other languages
English (en)
Inventor
Gunnar Aberg
Cullough John R Mc
Yue Fang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/381,542 external-priority patent/US5532278A/en
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ES2150663T3 publication Critical patent/ES2150663T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Abstract

LA INVENCION SE REFIERE A UN METODO PARA TRATAR LA INCONTINENCIA URINARIA A LA VEZ QUE EVITA EL INCONVENIENTE CONCOMITANTE DE LOS EFECTOS ADVERSOS ASOCIADOS A LA OXIBUTININA RACEMICA. EL METODO CONSISTE EN ADMINISTRAR UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE (5)-OXIBUTININA,(5)-DESETILOXIBUTININA O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLE,SUSTANCIALMENTE LIBRE DEL ENANTIOMERO R CORRESPONDIENTE. LA INVENCION TAMBIEN SE REFIERE A PASTILLAS Y DISPOSITIVOS TRANSDERMICOS QUE INCLUYEN (5)OXIBUTININA O (5)-DESETILOXIBUTININA Y UNA DE SUS PORTADORES ACEPTABLES, ASI COMO A UNA SINTESIS DE DESETILOXIBUTININA.
ES96906202T 1995-01-31 1996-01-25 Tratamiento de la incontinencia urinaria utilizando (s)-oxibutinina y (s)-desetiloxibutinina. Expired - Lifetime ES2150663T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/381,542 US5532278A (en) 1995-01-31 1995-01-31 Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
US08/480,194 US5677346A (en) 1995-01-31 1995-06-07 Treating urinary incontinence using (S)-desethyloxybutynin

Publications (1)

Publication Number Publication Date
ES2150663T3 true ES2150663T3 (es) 2000-12-01

Family

ID=27009434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96906202T Expired - Lifetime ES2150663T3 (es) 1995-01-31 1996-01-25 Tratamiento de la incontinencia urinaria utilizando (s)-oxibutinina y (s)-desetiloxibutinina.

Country Status (25)

Country Link
US (1) US5677346A (es)
EP (1) EP0806948B1 (es)
JP (1) JPH11511730A (es)
KR (1) KR100390271B1 (es)
CN (1) CN1151786C (es)
AT (1) ATE196252T1 (es)
AU (1) AU706741B2 (es)
BR (1) BR9607001A (es)
CA (1) CA2211400C (es)
CZ (1) CZ290093B6 (es)
DE (1) DE69610290T2 (es)
DK (1) DK0806948T3 (es)
ES (1) ES2150663T3 (es)
FI (1) FI973163A (es)
GR (1) GR3034974T3 (es)
HK (1) HK1017986A1 (es)
HU (1) HUP9800794A3 (es)
NO (1) NO315927B1 (es)
NZ (1) NZ303372A (es)
PL (1) PL182768B1 (es)
PT (1) PT806948E (es)
RU (1) RU2181589C2 (es)
SK (1) SK283313B6 (es)
UA (1) UA45387C2 (es)
WO (1) WO1996023492A1 (es)

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WO2003039436A2 (es) * 2001-11-06 2003-05-15 Osmotica Costa Rica Sociedad Anonima Composiciones farmaceuticas que contienen oxibutinina

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US5736577A (en) * 1995-01-31 1998-04-07 Sepracor, Inc. Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
US6171298B1 (en) 1996-05-03 2001-01-09 Situs Corporation Intravesical infuser
KR20010029519A (ko) * 1996-09-19 2001-04-06 이곤 이 버그 요실금 치료 방법
US6123961A (en) * 1996-09-25 2000-09-26 Bridge Pharma, Inc. Treating urinary incontinence with (R)-desethyloxybutynin and (R)-oxybutynin
JP2001527039A (ja) * 1997-12-31 2001-12-25 セプラコール， インク． 尿失禁を治療するためのｓ−プロサイクリディン
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
SI1039882T1 (sl) * 1998-08-27 2011-01-31 Pfizer Health Ab Terapevtska formulacija za dajanje tolterodina s kontroliranim sproščanjem
WO2000071108A2 (en) * 1999-05-20 2000-11-30 Sepracor Inc. Methods for treatment of asthma using s-oxybutynin
US6432446B2 (en) * 2000-02-03 2002-08-13 Bridge Pharma, Inc. Non-arrhythmogenic metabolite of oxybutynin
US6521724B2 (en) 2000-03-10 2003-02-18 E. I. Du Pont De Nemours And Company Polymerization process
US6436428B1 (en) 2000-03-21 2002-08-20 Enhance Pharmaceuticals, Inc. Device and method for treating urinary incontinence in females
BR0110381A (pt) * 2000-04-26 2003-12-30 Watson Pharmaceuticals Inc Minimizando experiência adversa associada com terapia com oxibutinina
US20030124177A1 (en) * 2000-04-26 2003-07-03 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7029694B2 (en) * 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
CN101108176A (zh) * 2000-06-07 2008-01-23 沃特森药物公司 用(r)-奥昔布宁和(r)-去乙基奥昔布宁治疗平滑肌机能亢进
ES2283425T3 (es) * 2000-08-03 2007-11-01 Antares Pharma Ipl Ag Nueva composicion para la administracion transdermica y/o transmucosa de compuestos activos que asegura niveles terapeutiocos adecuados.
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
DE10060550C1 (de) * 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
DE10103262A1 (de) * 2001-01-25 2002-08-01 Axel Schmidt-Dossi Arzneimittel gegen Blasenfunktionsstörung
DE60234318D1 (de) * 2001-02-08 2009-12-24 Ono Pharmaceutical Co Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors
CA2442281C (en) * 2001-03-27 2010-06-08 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
US20030027856A1 (en) * 2001-06-29 2003-02-06 Aberg A.K. Gunnar Tolterodine metabolites
EP1441706A2 (en) * 2001-11-05 2004-08-04 Pharmacia & Upjohn Company Antimuscarinic aerosol
US7921999B1 (en) * 2001-12-20 2011-04-12 Watson Laboratories, Inc. Peelable pouch for transdermal patch and method for packaging
JP2005516992A (ja) * 2001-12-21 2005-06-09 ブリッジ ファーマ、インコーポレイテッド オキシブチニンの非心律動異常惹起性代謝物
EP1426049B1 (en) * 2002-12-02 2005-05-18 Schwarz Pharma Ag Iontophoretic delivery of rotigotine for the treatment of Parkinson's disease
JP5619337B2 (ja) 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2008151092A1 (en) * 2007-05-30 2008-12-11 Microdose Therapeutx Inc. Methods and compositions for administration of oxybutynin
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8920392B2 (en) 2009-05-05 2014-12-30 Watson Laboratories, Inc. Method for treating overactive bladders and a device for storage and administration of topical oxybutynin compositions
EP2600859A1 (en) 2010-08-03 2013-06-12 Altherx Inc. Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
AR089957A1 (es) 2012-02-09 2014-10-01 Altherx Inc Combinaciones farmaceuticas, combinaciones sinergicas
JP2012176958A (ja) * 2012-04-20 2012-09-13 Watson Pharmaceuticals Inc （ｒ）−オキシブチニンおよび（ｒ）−デスエチルオキシブチニンによる平滑筋機能亢進の処置
US20140135392A1 (en) * 2012-11-13 2014-05-15 NeuRx Pharmaceuticals LLC Methods for the treatment of sialorrhea
US20160151321A1 (en) 2012-11-13 2016-06-02 Dinesh C. Patel Methods for the treatment of sialorrhea
CN104116760A (zh) * 2014-07-14 2014-10-29 玉庆花 一种治疗遗尿的口服液
KR20170086659A (ko) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법
ES2967863T3 (es) 2015-10-23 2024-05-06 B3Ar Therapeutics Inc Ion dipolar de solabegron y usos del mismo

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BE902605A (fr) * 1985-06-06 1985-09-30 Therabel Res S A N V Composition pharmaceutique utilisable dans le traitement des maladies des voies urinaires, son procede de preparation et methode d'utilisation de cette composition.
MX9202350A (es) * 1991-05-20 1992-11-01 Alza Corp Composiciones de incrementador de penetracion a la piel que usan monolinoleato de glicerol.
JP3066515B2 (ja) * 1992-11-11 2000-07-17 久光製薬株式会社 尿失禁治療用経皮投与製剤
NZ275615A (en) * 1993-09-29 1996-11-26 Alza Corp Oxybutynin composition containing monoglyceride and lactate ester as permeability enhancers; device for transdermal administration of oxybutynin

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039436A2 (es) * 2001-11-06 2003-05-15 Osmotica Costa Rica Sociedad Anonima Composiciones farmaceuticas que contienen oxibutinina
WO2003039519A2 (es) * 2001-11-06 2003-05-15 Osmotica Corp. Forma de dosificación de liberación controlada dual
WO2003039436A3 (es) * 2001-11-06 2004-02-26 Osmotica Costa Rica Sa Composiciones farmaceuticas que contienen oxibutinina
WO2003039519A3 (es) * 2001-11-06 2004-03-25 Osmotica Corp Forma de dosificación de liberación controlada dual

Also Published As

Publication number Publication date
EP0806948A1 (en) 1997-11-19
RU2181589C2 (ru) 2002-04-27
BR9607001A (pt) 1997-10-28
KR100390271B1 (ko) 2003-10-04
DE69610290D1 (de) 2000-10-19
US5677346A (en) 1997-10-14
MX9705820A (es) 1997-10-31
PL182768B1 (pl) 2002-02-28
DE69610290T2 (de) 2001-03-29
CA2211400A1 (en) 1996-08-08
NO973516D0 (no) 1997-07-30
CZ290093B6 (cs) 2002-05-15
WO1996023492A1 (en) 1996-08-08
SK103597A3 (en) 1999-03-12
NO315927B1 (no) 2003-11-17
CN1179714A (zh) 1998-04-22
HUP9800794A3 (en) 1999-05-28
PL321498A1 (en) 1997-12-08
NZ303372A (en) 1999-01-28
FI973163A0 (fi) 1997-07-30
NO973516L (no) 1997-08-07
DK0806948T3 (da) 2000-12-18
FI973163A (fi) 1997-09-30
ATE196252T1 (de) 2000-09-15
PT806948E (pt) 2001-02-28
CA2211400C (en) 2007-01-23
CN1151786C (zh) 2004-06-02
AU706741B2 (en) 1999-06-24
GR3034974T3 (en) 2001-02-28
AU4966496A (en) 1996-08-21
UA45387C2 (uk) 2002-04-15
HK1017986A1 (en) 1999-12-10
CZ242197A3 (en) 1997-12-17
SK283313B6 (sk) 2003-05-02
EP0806948B1 (en) 2000-09-13
HUP9800794A2 (hu) 1998-07-28
JPH11511730A (ja) 1999-10-12

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