NO314725B3 - N-substituerte indol-3-glyoksylamider, deres fremstilling, anvendelse for fremstilling av medikamenter, legemidler inneholdende disse samt en fremgangsmate for fremstilling av et legemiddel - Google Patents

N-substituerte indol-3-glyoksylamider, deres fremstilling, anvendelse for fremstilling av medikamenter, legemidler inneholdende disse samt en fremgangsmate for fremstilling av et legemiddel Download PDF

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Publication number
NO314725B3
NO314725B3 NO19991071A NO991071A NO314725B3 NO 314725 B3 NO314725 B3 NO 314725B3 NO 19991071 A NO19991071 A NO 19991071A NO 991071 A NO991071 A NO 991071A NO 314725 B3 NO314725 B3 NO 314725B3
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NO
Norway
Prior art keywords
substituted
alkyl
group
glyoxylamide
indol
Prior art date
Application number
NO19991071A
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English (en)
Norwegian (no)
Other versions
NO991071D0 (no
NO991071L (no
NO314725B1 (no
Inventor
Stefan Szelenyi
Kay Brune
Cecilia Menciu
Bernhard Kutscher
Guillaume Lebaut
Peter-Paul Emig
Original Assignee
Ziopharm Oncology Inc
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Filing date
Publication date
Application filed by Ziopharm Oncology Inc filed Critical Ziopharm Oncology Inc
Publication of NO991071D0 publication Critical patent/NO991071D0/no
Publication of NO991071L publication Critical patent/NO991071L/no
Publication of NO314725B1 publication Critical patent/NO314725B1/no
Publication of NO314725B3 publication Critical patent/NO314725B3/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO19991071A 1996-09-06 1999-03-04 N-substituerte indol-3-glyoksylamider, deres fremstilling, anvendelse for fremstilling av medikamenter, legemidler inneholdende disse samt en fremgangsmate for fremstilling av et legemiddel NO314725B3 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636150A DE19636150A1 (de) 1996-09-06 1996-09-06 N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
PCT/EP1997/004474 WO1998009946A1 (de) 1996-09-06 1997-08-16 N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung

Publications (4)

Publication Number Publication Date
NO991071D0 NO991071D0 (no) 1999-03-04
NO991071L NO991071L (no) 1999-03-04
NO314725B1 NO314725B1 (no) 2003-05-12
NO314725B3 true NO314725B3 (no) 2009-03-09

Family

ID=7804772

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19991071A NO314725B3 (no) 1996-09-06 1999-03-04 N-substituerte indol-3-glyoksylamider, deres fremstilling, anvendelse for fremstilling av medikamenter, legemidler inneholdende disse samt en fremgangsmate for fremstilling av et legemiddel
NO20030481A NO20030481D0 (no) 1996-09-06 2003-01-30 N-substituerte indol-3-glyoksylamider med antiastmatisk, antiallergisk og immunundertrykkende/immunmodulerende virkning

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20030481A NO20030481D0 (no) 1996-09-06 2003-01-30 N-substituerte indol-3-glyoksylamider med antiastmatisk, antiallergisk og immunundertrykkende/immunmodulerende virkning

Country Status (26)

Country Link
US (4) US6008231A (cs)
EP (1) EP0931063B3 (cs)
JP (1) JP3296437B2 (cs)
KR (1) KR100516321B1 (cs)
CN (3) CN100488948C (cs)
AR (1) AR008630A1 (cs)
AT (1) ATE342889T1 (cs)
AU (1) AU726521B2 (cs)
BR (1) BR9712808B1 (cs)
CA (1) CA2215013C (cs)
CZ (1) CZ302301B6 (cs)
DE (2) DE19636150A1 (cs)
DK (1) DK0931063T5 (cs)
ES (1) ES2276433T7 (cs)
HU (1) HU227797B1 (cs)
IL (1) IL127798A (cs)
NO (2) NO314725B3 (cs)
NZ (1) NZ334476A (cs)
PT (1) PT931063E (cs)
RU (1) RU2237661C2 (cs)
SK (1) SK285618B6 (cs)
TR (1) TR199900469T2 (cs)
TW (1) TW550256B (cs)
UA (1) UA60312C2 (cs)
WO (1) WO1998009946A1 (cs)
ZA (1) ZA977475B (cs)

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Also Published As

Publication number Publication date
EP0931063A1 (de) 1999-07-28
PT931063E (pt) 2007-02-28
DK0931063T5 (da) 2010-01-11
DE59712752D1 (de) 2006-11-30
US20020161025A1 (en) 2002-10-31
KR100516321B1 (ko) 2005-09-23
ZA977475B (en) 1998-02-19
US6919344B2 (en) 2005-07-19
ES2276433T7 (es) 2009-11-05
NO991071D0 (no) 1999-03-04
NO991071L (no) 1999-03-04
CA2215013C (en) 2002-03-05
AU4015897A (en) 1998-03-26
TW550256B (en) 2003-09-01
DK0931063T3 (da) 2007-02-19
UA60312C2 (uk) 2003-10-15
ES2276433T3 (es) 2007-06-16
HK1123280A1 (en) 2009-06-12
US20030207892A1 (en) 2003-11-06
BR9712808A (pt) 1999-11-23
TR199900469T2 (xx) 1999-05-21
RU2237661C2 (ru) 2004-10-10
JP3296437B2 (ja) 2002-07-02
US6008231A (en) 1999-12-28
BR9712808B1 (pt) 2009-05-05
JP2000505098A (ja) 2000-04-25
HUP9903741A2 (hu) 2000-04-28
IL127798A0 (en) 1999-10-28
CN101219985B (zh) 2011-04-27
HK1064379A1 (zh) 2005-01-28
SK27199A3 (en) 1999-08-06
CZ302301B6 (cs) 2011-02-09
NO20030481L (no) 1999-03-04
KR20000068495A (ko) 2000-11-25
NO314725B1 (no) 2003-05-12
NO20030481D0 (no) 2003-01-30
CN100376554C (zh) 2008-03-26
NZ334476A (en) 2000-05-26
WO1998009946A1 (de) 1998-03-12
CN1227542A (zh) 1999-09-01
CN101219985A (zh) 2008-07-16
EP0931063B1 (de) 2006-10-18
AR008630A1 (es) 2000-02-09
AU726521B2 (en) 2000-11-09
CA2215013A1 (en) 1998-03-06
HUP9903741A3 (en) 2001-01-29
HU227797B1 (en) 2012-03-28
EP0931063B3 (de) 2009-04-08
CN1496980A (zh) 2004-05-19
ATE342889T1 (de) 2006-11-15
US6344467B1 (en) 2002-02-05
CZ61699A3 (cs) 1999-06-16
CN100488948C (zh) 2009-05-20
AU726521C (en) 1998-03-26
SK285618B6 (sk) 2007-05-03
HK1021641A1 (zh) 2000-06-23
DE19636150A1 (de) 1998-03-12
IL127798A (en) 2003-07-31

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