DK0931063T5 - N-substitueret indol-3-glyoxylamid med antiastmatisk, antiallergisk og immunhæmmende/immunmodulerende virkning - Google Patents

N-substitueret indol-3-glyoxylamid med antiastmatisk, antiallergisk og immunhæmmende/immunmodulerende virkning

Info

Publication number
DK0931063T5
DK0931063T5 DK97937586T DK97937586T DK0931063T5 DK 0931063 T5 DK0931063 T5 DK 0931063T5 DK 97937586 T DK97937586 T DK 97937586T DK 97937586 T DK97937586 T DK 97937586T DK 0931063 T5 DK0931063 T5 DK 0931063T5
Authority
DK
Denmark
Prior art keywords
glyoxylamide
antiasthmatic
antiallergic
immunosuppressive
substituted indole
Prior art date
Application number
DK97937586T
Other languages
Danish (da)
English (en)
Other versions
DK0931063T3 (da
Inventor
Guillaume Lebaut
Cecilia Menciu
Bernhard Kutscher
Peter Emig
Stefan Szelenyi
Kay Brune
Original Assignee
Ziopharm Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ziopharm Oncology Inc filed Critical Ziopharm Oncology Inc
Application granted granted Critical
Publication of DK0931063T3 publication Critical patent/DK0931063T3/da
Publication of DK0931063T5 publication Critical patent/DK0931063T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK97937586T 1996-09-06 1997-08-16 N-substitueret indol-3-glyoxylamid med antiastmatisk, antiallergisk og immunhæmmende/immunmodulerende virkning DK0931063T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636150A DE19636150A1 (de) 1996-09-06 1996-09-06 N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
PCT/EP1997/004474 WO1998009946A1 (de) 1996-09-06 1997-08-16 N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung

Publications (2)

Publication Number Publication Date
DK0931063T3 DK0931063T3 (da) 2007-02-19
DK0931063T5 true DK0931063T5 (da) 2010-01-11

Family

ID=7804772

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97937586T DK0931063T5 (da) 1996-09-06 1997-08-16 N-substitueret indol-3-glyoxylamid med antiastmatisk, antiallergisk og immunhæmmende/immunmodulerende virkning

Country Status (26)

Country Link
US (4) US6008231A (cs)
EP (1) EP0931063B3 (cs)
JP (1) JP3296437B2 (cs)
KR (1) KR100516321B1 (cs)
CN (3) CN100488948C (cs)
AR (1) AR008630A1 (cs)
AT (1) ATE342889T1 (cs)
AU (1) AU726521B2 (cs)
BR (1) BR9712808B1 (cs)
CA (1) CA2215013C (cs)
CZ (1) CZ302301B6 (cs)
DE (2) DE19636150A1 (cs)
DK (1) DK0931063T5 (cs)
ES (1) ES2276433T7 (cs)
HU (1) HU227797B1 (cs)
IL (1) IL127798A (cs)
NO (2) NO314725B3 (cs)
NZ (1) NZ334476A (cs)
PT (1) PT931063E (cs)
RU (1) RU2237661C2 (cs)
SK (1) SK285618B6 (cs)
TR (1) TR199900469T2 (cs)
TW (1) TW550256B (cs)
UA (1) UA60312C2 (cs)
WO (1) WO1998009946A1 (cs)
ZA (1) ZA977475B (cs)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
TR200002869T2 (tr) * 1998-03-31 2000-12-21 The Institute For Pharmaceutical Discovery,Inc. İkame edilmiş indolealkonik asitler.
CZ302588B6 (cs) * 1998-04-02 2011-07-27 Ziopharm Oncology, Inc. Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
BR9910029A (pt) 1998-04-28 2000-12-26 Dresden Arzneimittel Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação
DE19917504A1 (de) * 1999-04-17 2000-10-19 Dresden Arzneimittel Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
TR200201317T2 (tr) 1999-08-21 2002-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Sinerjistik kombinasyon.
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
AU2002323474B2 (en) * 2001-09-13 2006-10-05 Synta Pharmaceuticals Corp 3-glyoxlylamideindoles for treating cancer
RU2337906C2 (ru) * 2001-12-03 2008-11-10 Уайт Ингибиторы цитозольной фосфолипазы а2
US6903104B2 (en) * 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
MXPA05001011A (es) * 2002-07-26 2005-06-08 Inst For Pharm Discovery Inc Derivado de acidos indolalcanoicos substituidos y formulaciones que lo contienen para uso en tratamiento de complicaciones diabeticas.
US7122674B2 (en) * 2002-08-01 2006-10-17 Elbion Ag Process for preparing high-purity hydroxyindolylglyoxylamides
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318611A1 (de) 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
DE10334040A1 (de) * 2003-07-25 2005-03-10 Zentaris Gmbh Neue N-substituierte Indolyl-3-glyoxylsäureamide, deren Verwendung als Arzneimittel und Verfahren zu deren Herstellung
US7749999B2 (en) 2003-09-11 2010-07-06 Itherx Pharmaceuticals, Inc. Alpha-ketoamides and derivatives thereof
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
CA2587276A1 (en) * 2004-11-08 2006-05-18 Baxter International Inc. Nanoparticulate compositions of tubulin inhibitor compounds
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
ES2644450T3 (es) 2004-12-31 2017-11-29 Dr. Reddy's Laboratories Ltd. Nuevos derivados de bencilamina como inhibidores de CETP
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
JP2006247963A (ja) * 2005-03-09 2006-09-21 Oji Paper Co Ltd インクジェット記録用シート
JP5385605B2 (ja) * 2005-03-11 2014-01-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーター
US7328672B2 (en) 2005-04-29 2008-02-12 Tendik Development, Llc Radial impulse engine, pump, and compressor systems, and associated methods of operation
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
ITMI20051999A1 (it) * 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
KR101433394B1 (ko) 2006-07-05 2014-08-26 다케다 게엠베하 염증성 폐질환의 치료를 위한 ＨＭＧ-ＣｏＡ 리덕타제 억제제와 포스포디에스터라제 4 억제제의 병용
CA2660704A1 (en) * 2006-08-07 2008-02-14 Ironwood Pharmaceuticals, Inc. Indole compounds
EP2066619A2 (en) * 2006-11-02 2009-06-10 Arete Therapeutics, INC. Soluble epoxide hydrolase inhibitors
WO2008066807A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP3563842A1 (en) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
KR101774223B1 (ko) 2011-08-18 2017-09-12 닥터 레디스 레보러터리즈 리미티드 콜레스테릴 에스테르-전달 단백질(cetp) 억제제인 치환된 헤테로시클릭 아민 화합물
IN2014CN02290A (cs) 2011-09-27 2015-06-19 Reddys Lab Ltd Dr
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
CN109000634B (zh) * 2018-06-04 2022-06-03 上海智蕙林医疗科技有限公司 一种导航对象行进路线的提醒方法和系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB797258A (en) * 1955-04-11 1958-06-25 Upjohn Co 3-substituted indoles
GB944443A (cs) * 1959-09-25 1900-01-01
GB1028812A (en) * 1962-08-28 1966-05-11 Ici Ltd Indole derivatives
GB1089071A (en) * 1964-02-28 1967-11-01 Merck & Co Inc Indole derivatives
US3686213A (en) * 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
SU457698A1 (ru) * 1972-10-20 1975-01-25 Всесоюзный научно-исследовательский химико-фармацевтический институт им. Серго Орджоникидзе Способ получени производных индолил-2-уксусной кислоты
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
HUT72048A (en) * 1994-04-01 1996-03-28 Lilly Co Eli 1h-indole-3-glyoxylamide spla2 inhibitors and pharmaceutical compositions containing these compounds
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
US7205299B2 (en) * 2003-06-05 2007-04-17 Zentaris Gmbh Indole derivatives having an apoptosis-inducing effect

Also Published As

Publication number Publication date
EP0931063A1 (de) 1999-07-28
PT931063E (pt) 2007-02-28
DE59712752D1 (de) 2006-11-30
US20020161025A1 (en) 2002-10-31
KR100516321B1 (ko) 2005-09-23
ZA977475B (en) 1998-02-19
US6919344B2 (en) 2005-07-19
ES2276433T7 (es) 2009-11-05
NO991071D0 (no) 1999-03-04
NO991071L (no) 1999-03-04
CA2215013C (en) 2002-03-05
AU4015897A (en) 1998-03-26
TW550256B (en) 2003-09-01
DK0931063T3 (da) 2007-02-19
UA60312C2 (uk) 2003-10-15
ES2276433T3 (es) 2007-06-16
HK1123280A1 (en) 2009-06-12
US20030207892A1 (en) 2003-11-06
BR9712808A (pt) 1999-11-23
TR199900469T2 (xx) 1999-05-21
RU2237661C2 (ru) 2004-10-10
JP3296437B2 (ja) 2002-07-02
US6008231A (en) 1999-12-28
BR9712808B1 (pt) 2009-05-05
JP2000505098A (ja) 2000-04-25
HUP9903741A2 (hu) 2000-04-28
IL127798A0 (en) 1999-10-28
CN101219985B (zh) 2011-04-27
HK1064379A1 (zh) 2005-01-28
SK27199A3 (en) 1999-08-06
CZ302301B6 (cs) 2011-02-09
NO20030481L (no) 1999-03-04
KR20000068495A (ko) 2000-11-25
NO314725B1 (no) 2003-05-12
NO20030481D0 (no) 2003-01-30
CN100376554C (zh) 2008-03-26
NZ334476A (en) 2000-05-26
WO1998009946A1 (de) 1998-03-12
CN1227542A (zh) 1999-09-01
CN101219985A (zh) 2008-07-16
EP0931063B1 (de) 2006-10-18
AR008630A1 (es) 2000-02-09
AU726521B2 (en) 2000-11-09
CA2215013A1 (en) 1998-03-06
HUP9903741A3 (en) 2001-01-29
HU227797B1 (en) 2012-03-28
EP0931063B3 (de) 2009-04-08
CN1496980A (zh) 2004-05-19
NO314725B3 (no) 2009-03-09
ATE342889T1 (de) 2006-11-15
US6344467B1 (en) 2002-02-05
CZ61699A3 (cs) 1999-06-16
CN100488948C (zh) 2009-05-20
AU726521C (en) 1998-03-26
SK285618B6 (sk) 2007-05-03
HK1021641A1 (zh) 2000-06-23
DE19636150A1 (de) 1998-03-12
IL127798A (en) 2003-07-31

Similar Documents

Publication Publication Date Title
DK0931063T5 (da) N-substitueret indol-3-glyoxylamid med antiastmatisk, antiallergisk og immunhæmmende/immunmodulerende virkning
IL121298A (en) N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their uses
DE59711118D1 (de) Spickeln, Zunehmen und Mindern
DE69734126D1 (de) Druckverfahren und Gerät
DE69729947T2 (de) N-substituierte 2-cyanopyrrolidine
DE19581855T1 (de) Schlagvorrichtung und Schlagverfahren
DE69932265D1 (de) Musikaktionsspielsystem und computerlesbare Aufzeichnungsvorrichtung
NO984354D0 (no) Avisingsmiddel og anvendelse av dette
DE69704781D1 (de) Trainingsverfahren und-gerät
HUP0004200A3 (en) Cyclic amine derivatives and their use as drugs
DE69725045D1 (de) Tintenstrahldruckverfahren und Gerät
DE69816946D1 (de) Druckkompensationvorrichtung und Druckkompensationverfahren
IL121299A0 (en) 4-hydroxy-piperidine derivatives and their uses
PL329351A1 (en) Piperidines and pyrolydines
DE69724852D1 (de) Tintenstrahldruckgerät und Druckverfahren
EP0687668A3 (en) Meta-phenylenediamine derivatives and electro-photosensitive material using them
DE69713817D1 (de) Schutzabdeckung und damit ausgestatteter Apparat
DE69727047D1 (de) Entpaketierer und rahmenausgleicher damit
NO985806L (no) Kitinasematerialer og fremgangsmÕter
DE69718239D1 (de) Druckvorrichtung und Druckkopf
DE69722739D1 (de) Tintenstrahldruckvorrichtung und Tintenstrahldruckverfahren
DE59706929D1 (de) Balancier-Hebegerät
DK1042286T3 (da) Gamme-glutamyl- og beta-aspartyl-holdige immunmodulerende forbindelser og tilhørense fremgangsmåder
DE69809829D1 (de) Untergrunderkennung und Kompensation
MXPA01011288A (es) Derivados de ciclocarbamato y amida ciclica.