NO313239B1 - Nye N-7-heterocyklylpyrrolo[2,3-d]pyridiner, farmasöytiske preparater som inneholder disse forbindelser, fremgangsmåte forfremstilling av forbindelsene - Google Patents
Nye N-7-heterocyklylpyrrolo[2,3-d]pyridiner, farmasöytiske preparater som inneholder disse forbindelser, fremgangsmåte forfremstilling av forbindelsene Download PDFInfo
- Publication number
- NO313239B1 NO313239B1 NO19984199A NO984199A NO313239B1 NO 313239 B1 NO313239 B1 NO 313239B1 NO 19984199 A NO19984199 A NO 19984199A NO 984199 A NO984199 A NO 984199A NO 313239 B1 NO313239 B1 NO 313239B1
- Authority
- NO
- Norway
- Prior art keywords
- pyrrolo
- amino
- pyrimidin
- formula
- compound
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 102
- 238000000034 method Methods 0.000 title claims description 27
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 15
- 230000008569 process Effects 0.000 title claims description 4
- 150000003222 pyridines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 68
- -1 carboxy, methoxycarbonyl Chemical group 0.000 claims description 63
- 150000003839 salts Chemical class 0.000 claims description 52
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 35
- 125000003545 alkoxy group Chemical group 0.000 claims description 25
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 14
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 12
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims description 11
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
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- 230000005764 inhibitory process Effects 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 238000007363 ring formation reaction Methods 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 5
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 5
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- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical class [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 108700026239 src Genes Proteins 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003899 tartaric acid esters Chemical class 0.000 description 1
- MRJBWROYUAPQFC-UHFFFAOYSA-N tert-butyl 4-[4-amino-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1N1C2=NC=NC(N)=C2C(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=C1 MRJBWROYUAPQFC-UHFFFAOYSA-N 0.000 description 1
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 description 1
- LPQZERIRKRYGGM-UHFFFAOYSA-N tert-butyl pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC1 LPQZERIRKRYGGM-UHFFFAOYSA-N 0.000 description 1
- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical group CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH69496 | 1996-03-15 | ||
PCT/EP1997/001095 WO1997034895A1 (de) | 1996-03-15 | 1997-03-05 | NEUE N-7 HETEROCYCLYL-PYRROLO[2,3-d]PYRIMIDINE UND IHRE VERWENDUNG |
Publications (3)
Publication Number | Publication Date |
---|---|
NO984199D0 NO984199D0 (no) | 1998-09-11 |
NO984199L NO984199L (no) | 1998-11-05 |
NO313239B1 true NO313239B1 (no) | 2002-09-02 |
Family
ID=4192986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984199A NO313239B1 (no) | 1996-03-15 | 1998-09-11 | Nye N-7-heterocyklylpyrrolo[2,3-d]pyridiner, farmasöytiske preparater som inneholder disse forbindelser, fremgangsmåte forfremstilling av forbindelsene |
Country Status (16)
Country | Link |
---|---|
US (1) | US6051577A (xx) |
EP (1) | EP0888353B1 (xx) |
JP (1) | JP4326024B2 (xx) |
KR (1) | KR20000064601A (xx) |
CN (1) | CN1079796C (xx) |
AT (1) | ATE244719T1 (xx) |
AU (1) | AU716383B2 (xx) |
BR (1) | BR9709443B1 (xx) |
CA (1) | CA2249739A1 (xx) |
DE (1) | DE59710417D1 (xx) |
DK (1) | DK0888353T3 (xx) |
ES (1) | ES2203793T3 (xx) |
NO (1) | NO313239B1 (xx) |
NZ (1) | NZ331804A (xx) |
PT (1) | PT888353E (xx) |
WO (1) | WO1997034895A1 (xx) |
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DE69732780T2 (de) | 1996-10-02 | 2006-04-06 | Novartis Ag | Pyrimiderivate und verfahren zu ihrer herstellung |
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HUP0001507A3 (en) * | 1997-03-19 | 2002-01-28 | Abbott Gmbh & Co Kg | Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
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TWI242011B (en) | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
US6713474B2 (en) * | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
KR20010085824A (ko) * | 1998-09-18 | 2001-09-07 | 스타르크, 카르크 | 단백질 키나아제 억제제로서의 피롤로피리미딘 |
UA71587C2 (uk) * | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
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JP2024516450A (ja) | 2021-05-05 | 2024-04-15 | レボリューション メディシンズ インコーポレイテッド | 共有結合性ras阻害剤及びその使用 |
TW202309053A (zh) | 2021-05-05 | 2023-03-01 | 美商銳新醫藥公司 | Ras抑制劑 |
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Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2100863A1 (en) * | 1991-01-23 | 1992-07-24 | David A. Bullough | Adenosine kinase inhibitors |
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1997
- 1997-03-05 DE DE59710417T patent/DE59710417D1/de not_active Expired - Lifetime
- 1997-03-05 DK DK97914189T patent/DK0888353T3/da active
- 1997-03-05 US US09/142,548 patent/US6051577A/en not_active Expired - Fee Related
- 1997-03-05 NZ NZ331804A patent/NZ331804A/xx unknown
- 1997-03-05 BR BRPI9709443-9A patent/BR9709443B1/pt not_active IP Right Cessation
- 1997-03-05 KR KR1019980707280A patent/KR20000064601A/ko not_active Application Discontinuation
- 1997-03-05 AU AU21534/97A patent/AU716383B2/en not_active Ceased
- 1997-03-05 AT AT97914189T patent/ATE244719T1/de active
- 1997-03-05 CN CN97193839A patent/CN1079796C/zh not_active Expired - Fee Related
- 1997-03-05 ES ES97914189T patent/ES2203793T3/es not_active Expired - Lifetime
- 1997-03-05 WO PCT/EP1997/001095 patent/WO1997034895A1/de not_active Application Discontinuation
- 1997-03-05 CA CA002249739A patent/CA2249739A1/en not_active Abandoned
- 1997-03-05 EP EP97914189A patent/EP0888353B1/de not_active Expired - Lifetime
- 1997-03-05 PT PT97914189T patent/PT888353E/pt unknown
- 1997-03-05 JP JP53308197A patent/JP4326024B2/ja not_active Expired - Fee Related
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1998
- 1998-09-11 NO NO19984199A patent/NO313239B1/no not_active IP Right Cessation
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Publication number | Publication date |
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BR9709443A (pt) | 1999-08-10 |
JP2000506537A (ja) | 2000-05-30 |
AU716383B2 (en) | 2000-02-24 |
NZ331804A (en) | 2000-04-28 |
EP0888353A1 (de) | 1999-01-07 |
BR9709443B1 (pt) | 2009-05-05 |
KR20000064601A (ko) | 2000-11-06 |
NO984199L (no) | 1998-11-05 |
CA2249739A1 (en) | 1997-09-25 |
WO1997034895A1 (de) | 1997-09-25 |
DE59710417D1 (de) | 2003-08-14 |
CN1216544A (zh) | 1999-05-12 |
JP4326024B2 (ja) | 2009-09-02 |
NO984199D0 (no) | 1998-09-11 |
CN1079796C (zh) | 2002-02-27 |
AU2153497A (en) | 1997-10-10 |
US6051577A (en) | 2000-04-18 |
ATE244719T1 (de) | 2003-07-15 |
ES2203793T3 (es) | 2004-04-16 |
PT888353E (pt) | 2003-11-28 |
DK0888353T3 (da) | 2003-10-27 |
EP0888353B1 (de) | 2003-07-09 |
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