NO310917B1 - 11-Acetyl-12,13-dioksabisyklo[8.2.1.]-tridekenonderivater, fremgangsmater for deres fremstilling, samt legemidlerinneholdende slike forbindelser - Google Patents
11-Acetyl-12,13-dioksabisyklo[8.2.1.]-tridekenonderivater, fremgangsmater for deres fremstilling, samt legemidlerinneholdende slike forbindelser Download PDFInfo
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- NO310917B1 NO310917B1 NO19990675A NO990675A NO310917B1 NO 310917 B1 NO310917 B1 NO 310917B1 NO 19990675 A NO19990675 A NO 19990675A NO 990675 A NO990675 A NO 990675A NO 310917 B1 NO310917 B1 NO 310917B1
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- methyl
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- compound
- acetyl
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- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940057428 lactoperoxidase Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- KNWQLFOXPQZGPX-UHFFFAOYSA-N methanesulfonyl fluoride Chemical compound CS(F)(=O)=O KNWQLFOXPQZGPX-UHFFFAOYSA-N 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- ODKLEQPZOCJQMT-UHFFFAOYSA-N n,n-diethylpyridin-4-amine Chemical compound CCN(CC)C1=CC=NC=C1 ODKLEQPZOCJQMT-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19805822A DE19805822B4 (de) | 1998-02-13 | 1998-02-13 | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO990675D0 NO990675D0 (no) | 1999-02-12 |
| NO990675L NO990675L (no) | 1999-08-16 |
| NO310917B1 true NO310917B1 (no) | 2001-09-17 |
Family
ID=7857548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19990675A NO310917B1 (no) | 1998-02-13 | 1999-02-12 | 11-Acetyl-12,13-dioksabisyklo[8.2.1.]-tridekenonderivater, fremgangsmater for deres fremstilling, samt legemidlerinneholdende slike forbindelser |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0937734B1 (es) |
| JP (1) | JPH11269193A (es) |
| KR (1) | KR100584017B1 (es) |
| CN (1) | CN1189473C (es) |
| AR (1) | AR014320A1 (es) |
| AT (1) | ATE486083T1 (es) |
| AU (1) | AU748670B2 (es) |
| BR (1) | BR9900442A (es) |
| CA (1) | CA2260315C (es) |
| CZ (1) | CZ294879B6 (es) |
| DE (2) | DE19805822B4 (es) |
| DZ (1) | DZ2721A1 (es) |
| ES (1) | ES2355187T3 (es) |
| HK (1) | HK1023575A1 (es) |
| HU (1) | HU222539B1 (es) |
| ID (1) | ID21968A (es) |
| IL (1) | IL128238A (es) |
| NO (1) | NO310917B1 (es) |
| NZ (1) | NZ334087A (es) |
| PL (1) | PL192281B1 (es) |
| RU (1) | RU2218346C2 (es) |
| SK (1) | SK285313B6 (es) |
| TR (1) | TR199900285A2 (es) |
| TW (1) | TW579379B (es) |
| UA (1) | UA57030C2 (es) |
| ZA (1) | ZA99678B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6734292B1 (en) | 2000-08-17 | 2004-05-11 | The Kitasato Institute | Pseudoerythromycin derivatives |
| GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| EP1902022A1 (en) | 2005-07-12 | 2008-03-26 | Glaxo Group Limited | Piperazine heteroaryl derivates as gpr38 agonists |
| SI1907374T1 (sl) | 2005-07-26 | 2012-11-30 | Glaxo Group Ltd | Derivati benzilpiperazina uporabni za zdravljenje gastrointestinalnih motenj |
| PE20080345A1 (es) | 2006-06-28 | 2008-05-29 | Glaxo Group Ltd | Derivados de piperazina como agonistas del receptor de gpr38 |
| BRPI1007962A2 (pt) | 2009-02-27 | 2016-02-23 | Raqualia Pharma Inc | composto de fórmula (i), composição farmacêutica contendo o mesmo, uso do mesmo ou de seu sal farmaceuticamente aceitável e método para o tratamento de uma doença mediada pela atividade agonística de receptor de motilina, em um indíviduo mamífero, incluindo um ser humano. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
| US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
| NZ232375A (en) * | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5712253A (en) * | 1996-06-18 | 1998-01-27 | Abbott Laboratories | Macrocyclic 13-membered ring derivatives of erythromycins A and B |
-
1998
- 1998-02-13 DE DE19805822A patent/DE19805822B4/de not_active Expired - Fee Related
-
1999
- 1999-01-15 AR ARP990100149A patent/AR014320A1/es not_active Application Discontinuation
- 1999-01-25 CA CA002260315A patent/CA2260315C/en not_active Expired - Fee Related
- 1999-01-26 IL IL12823899A patent/IL128238A/en unknown
- 1999-01-27 TW TW088101211A patent/TW579379B/zh not_active IP Right Cessation
- 1999-01-28 ZA ZA9900678A patent/ZA99678B/xx unknown
- 1999-02-01 KR KR1019990003207A patent/KR100584017B1/ko not_active IP Right Cessation
- 1999-02-05 SK SK150-99A patent/SK285313B6/sk unknown
- 1999-02-05 HU HU9900263A patent/HU222539B1/hu not_active IP Right Cessation
- 1999-02-08 EP EP99101675A patent/EP0937734B1/de not_active Expired - Lifetime
- 1999-02-08 ES ES99101675T patent/ES2355187T3/es not_active Expired - Lifetime
- 1999-02-08 NZ NZ334087A patent/NZ334087A/xx unknown
- 1999-02-08 DE DE59915209T patent/DE59915209D1/de not_active Expired - Lifetime
- 1999-02-08 AT AT99101675T patent/ATE486083T1/de active
- 1999-02-10 CZ CZ1999458A patent/CZ294879B6/cs not_active IP Right Cessation
- 1999-02-10 DZ DZ990022A patent/DZ2721A1/xx active
- 1999-02-10 JP JP11032750A patent/JPH11269193A/ja active Pending
- 1999-02-10 BR BR9900442-9A patent/BR9900442A/pt not_active Application Discontinuation
- 1999-02-10 TR TR1999/00285A patent/TR199900285A2/xx unknown
- 1999-02-11 CN CNB991021266A patent/CN1189473C/zh not_active Expired - Fee Related
- 1999-02-11 UA UA99020798A patent/UA57030C2/uk unknown
- 1999-02-12 RU RU99102852/04A patent/RU2218346C2/ru not_active IP Right Cessation
- 1999-02-12 PL PL331444A patent/PL192281B1/pl unknown
- 1999-02-12 AU AU16438/99A patent/AU748670B2/en not_active Ceased
- 1999-02-12 NO NO19990675A patent/NO310917B1/no unknown
- 1999-02-12 ID IDP990111D patent/ID21968A/id unknown
-
2000
- 2000-04-28 HK HK00102579A patent/HK1023575A1/xx not_active IP Right Cessation
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