NZ334087A - 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives - Google Patents

11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives

Info

Publication number
NZ334087A
NZ334087A NZ334087A NZ33408799A NZ334087A NZ 334087 A NZ334087 A NZ 334087A NZ 334087 A NZ334087 A NZ 334087A NZ 33408799 A NZ33408799 A NZ 33408799A NZ 334087 A NZ334087 A NZ 334087A
Authority
NZ
New Zealand
Prior art keywords
dioxabicyclo
acetyl
tridecenone
derivatives
tridec
Prior art date
Application number
NZ334087A
Inventor
Daniel Jasserand
Ulf Preuschoff
Christian Eeckhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NZ334087A publication Critical patent/NZ334087A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The (2R, 3S, 4S, 5R, 6R, 10R, 11R)-2,4,6,8,10-pentamethyl-11-acetyl-12,13-dioxabicyclo[8.2.1]-tridec-8-ene-1-one compound or a pharmaceutically acceptable salt thereof has the formula (I) wherein: R1 is H or methyl and R2 is H or alkanoyl. A pharmaceutical composition thereof is useful as a motilin agent
NZ334087A 1998-02-13 1999-02-08 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives NZ334087A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19805822A DE19805822B4 (en) 1998-02-13 1998-02-13 11-Acetyl-12,13-dioxabicyclo [8.2.1] tridecenone derivatives, process for their preparation and medicaments containing these compounds

Publications (1)

Publication Number Publication Date
NZ334087A true NZ334087A (en) 2000-07-28

Family

ID=7857548

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ334087A NZ334087A (en) 1998-02-13 1999-02-08 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives

Country Status (26)

Country Link
EP (1) EP0937734B1 (en)
JP (1) JPH11269193A (en)
KR (1) KR100584017B1 (en)
CN (1) CN1189473C (en)
AR (1) AR014320A1 (en)
AT (1) ATE486083T1 (en)
AU (1) AU748670B2 (en)
BR (1) BR9900442A (en)
CA (1) CA2260315C (en)
CZ (1) CZ294879B6 (en)
DE (2) DE19805822B4 (en)
DZ (1) DZ2721A1 (en)
ES (1) ES2355187T3 (en)
HK (1) HK1023575A1 (en)
HU (1) HU222539B1 (en)
ID (1) ID21968A (en)
IL (1) IL128238A (en)
NO (1) NO310917B1 (en)
NZ (1) NZ334087A (en)
PL (1) PL192281B1 (en)
RU (1) RU2218346C2 (en)
SK (1) SK285313B6 (en)
TR (1) TR199900285A2 (en)
TW (1) TW579379B (en)
UA (1) UA57030C2 (en)
ZA (1) ZA99678B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734292B1 (en) 2000-08-17 2004-05-11 The Kitasato Institute Pseudoerythromycin derivatives
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
EP1902022A1 (en) 2005-07-12 2008-03-26 Glaxo Group Limited Piperazine heteroaryl derivates as gpr38 agonists
SI1907374T1 (en) 2005-07-26 2012-11-30 Glaxo Group Ltd Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders
PE20080345A1 (en) 2006-06-28 2008-05-29 Glaxo Group Ltd PIPERAZINE DERIVATIVES AS AGONISTS OF THE GPR38 RECEPTOR
BRPI1007962A2 (en) 2009-02-27 2016-02-23 Raqualia Pharma Inc compound of formula (I), pharmaceutical composition containing same, use thereof or pharmaceutically acceptable salt thereof and method for treating a disease mediated by motilin receptor agonistic activity in an individual mammal, including a human.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DE4200145A1 (en) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-EPOXY-OXACYCLODODANE DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B

Also Published As

Publication number Publication date
TW579379B (en) 2004-03-11
IL128238A0 (en) 1999-11-30
SK285313B6 (en) 2006-10-05
BR9900442A (en) 2000-05-02
ES2355187T3 (en) 2011-03-23
ATE486083T1 (en) 2010-11-15
DE59915209D1 (en) 2010-12-09
ID21968A (en) 1999-08-19
ZA99678B (en) 1999-07-28
HUP9900263A3 (en) 2000-04-28
CN1239718A (en) 1999-12-29
JPH11269193A (en) 1999-10-05
CZ45899A3 (en) 1999-09-15
KR19990072345A (en) 1999-09-27
AU748670B2 (en) 2002-06-06
NO990675D0 (en) 1999-02-12
HUP9900263A2 (en) 1999-09-28
HK1023575A1 (en) 2000-09-15
CZ294879B6 (en) 2005-04-13
DZ2721A1 (en) 2003-09-01
RU2218346C2 (en) 2003-12-10
CA2260315C (en) 2008-04-08
PL192281B1 (en) 2006-09-29
CA2260315A1 (en) 1999-08-13
TR199900285A3 (en) 1999-09-21
HU222539B1 (en) 2003-08-28
TR199900285A2 (en) 1999-09-21
EP0937734B1 (en) 2010-10-27
KR100584017B1 (en) 2006-05-30
IL128238A (en) 2001-09-13
AU1643899A (en) 1999-08-26
PL331444A1 (en) 1999-08-16
UA57030C2 (en) 2003-06-16
SK15099A3 (en) 2000-01-18
DE19805822B4 (en) 2009-02-05
NO310917B1 (en) 2001-09-17
CN1189473C (en) 2005-02-16
DE19805822A1 (en) 1999-08-19
EP0937734A1 (en) 1999-08-25
NO990675L (en) 1999-08-16
HU9900263D0 (en) 1999-04-28
AR014320A1 (en) 2001-02-07

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