NO308951B1 - AnalogifremgangsmÕte for fremstilling av terapeutisk aktive korte peptider med insulinvirkning - Google Patents
AnalogifremgangsmÕte for fremstilling av terapeutisk aktive korte peptider med insulinvirkning Download PDFInfo
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- NO308951B1 NO308951B1 NO914999A NO914999A NO308951B1 NO 308951 B1 NO308951 B1 NO 308951B1 NO 914999 A NO914999 A NO 914999A NO 914999 A NO914999 A NO 914999A NO 308951 B1 NO308951 B1 NO 308951B1
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- insulin
- glucose
- peptide
- asn
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- 239000012452 mother liquor Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- ZUSSTQCWRDLYJA-UHFFFAOYSA-N n-hydroxy-5-norbornene-2,3-dicarboximide Chemical compound C1=CC2CC1C1C2C(=O)N(O)C1=O ZUSSTQCWRDLYJA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- -1 pentose phosphate Chemical class 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 108010066381 preproinsulin Proteins 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4040574 | 1990-12-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO914999D0 NO914999D0 (no) | 1991-12-18 |
| NO914999L NO914999L (no) | 1992-06-22 |
| NO308951B1 true NO308951B1 (no) | 2000-11-20 |
Family
ID=6420676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO914999A NO308951B1 (no) | 1990-12-19 | 1991-12-18 | AnalogifremgangsmÕte for fremstilling av terapeutisk aktive korte peptider med insulinvirkning |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5461035A (es) |
| EP (1) | EP0491361B1 (es) |
| JP (2) | JP3378588B2 (es) |
| KR (1) | KR100237948B1 (es) |
| AT (1) | ATE177753T1 (es) |
| AU (1) | AU643349B2 (es) |
| CA (1) | CA2058020C (es) |
| CZ (1) | CZ284568B6 (es) |
| DE (1) | DE59109109D1 (es) |
| DK (1) | DK0491361T3 (es) |
| ES (1) | ES2130130T3 (es) |
| FI (1) | FI105816B (es) |
| GR (1) | GR3030510T3 (es) |
| HR (1) | HRP940839B1 (es) |
| HU (1) | HU222493B1 (es) |
| IE (1) | IE914408A1 (es) |
| IL (1) | IL100400A (es) |
| NO (1) | NO308951B1 (es) |
| NZ (1) | NZ241029A (es) |
| PT (1) | PT99850B (es) |
| SK (2) | SK282360B6 (es) |
| TW (1) | TW227004B (es) |
| YU (1) | YU189891A (es) |
| ZA (1) | ZA919938B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2137937T3 (es) * | 1991-11-29 | 2000-01-01 | Hoechst Ag | Peptidos con efecto del tipo de insulina. |
| SE0002716L (sv) * | 2000-07-18 | 2002-01-19 | Lars Wahlberg | Komposition mot insekter |
| JP4437005B2 (ja) * | 2001-01-15 | 2010-03-24 | ソシエテ ド テクノロジー ミシュラン | タイヤカーカス用造形ドラム |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| KR101909052B1 (ko) | 2017-02-09 | 2018-10-17 | 강원대학교산학협력단 | 인슐린의 a 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2740406A1 (de) * | 1977-09-08 | 1979-03-22 | Hoechst Ag | Teilgeschuetzte human-insulin-a-kette und verfahren zu ihrer herstellung |
| DE2801175A1 (de) * | 1978-01-12 | 1979-07-19 | Hoechst Ag | Verfahren zur herstellung cysteinhaltiger peptide |
| DD147942A1 (de) * | 1979-08-20 | 1981-04-29 | Guenter Losse | Verfahren zur herstellung von cystin-peptiden mit insulinaehnlicher wirkung |
| FR2525592B1 (es) * | 1982-04-26 | 1984-09-14 | Pasteur Institut |
-
1991
- 1991-11-28 TW TW080109358A patent/TW227004B/zh not_active IP Right Cessation
- 1991-12-06 YU YU189891A patent/YU189891A/sh unknown
- 1991-12-17 DE DE59109109T patent/DE59109109D1/de not_active Expired - Lifetime
- 1991-12-17 FI FI915933A patent/FI105816B/fi active
- 1991-12-17 EP EP91121624A patent/EP0491361B1/de not_active Expired - Lifetime
- 1991-12-17 IL IL100400A patent/IL100400A/en not_active IP Right Cessation
- 1991-12-17 DK DK91121624T patent/DK0491361T3/da active
- 1991-12-17 AT AT91121624T patent/ATE177753T1/de not_active IP Right Cessation
- 1991-12-17 ES ES91121624T patent/ES2130130T3/es not_active Expired - Lifetime
- 1991-12-17 NZ NZ241029A patent/NZ241029A/xx not_active IP Right Cessation
- 1991-12-18 ZA ZA919938A patent/ZA919938B/xx unknown
- 1991-12-18 CZ CS913879A patent/CZ284568B6/cs not_active IP Right Cessation
- 1991-12-18 CA CA002058020A patent/CA2058020C/en not_active Expired - Lifetime
- 1991-12-18 SK SK3879-91A patent/SK282360B6/sk not_active IP Right Cessation
- 1991-12-18 NO NO914999A patent/NO308951B1/no not_active IP Right Cessation
- 1991-12-18 SK SK232-2001A patent/SK282361B6/sk not_active IP Right Cessation
- 1991-12-18 KR KR1019910023282A patent/KR100237948B1/ko not_active IP Right Cessation
- 1991-12-18 HU HU9104009A patent/HU222493B1/hu active IP Right Grant
- 1991-12-18 PT PT99850A patent/PT99850B/pt not_active IP Right Cessation
- 1991-12-18 AU AU89825/91A patent/AU643349B2/en not_active Expired
- 1991-12-18 JP JP33475591A patent/JP3378588B2/ja not_active Expired - Lifetime
- 1991-12-18 IE IE440891A patent/IE914408A1/en not_active IP Right Cessation
-
1994
- 1994-08-04 US US08/285,443 patent/US5461035A/en not_active Expired - Lifetime
- 1994-10-26 HR HRP-1898/91A patent/HRP940839B1/xx not_active IP Right Cessation
-
1999
- 1999-06-15 GR GR990401585T patent/GR3030510T3/el unknown
-
2002
- 2002-10-02 JP JP2002289401A patent/JP3802863B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |