ES2130130T3 - Peptidos cortos con efecto de insulina. - Google Patents

Peptidos cortos con efecto de insulina.

Info

Publication number
ES2130130T3
ES2130130T3 ES91121624T ES91121624T ES2130130T3 ES 2130130 T3 ES2130130 T3 ES 2130130T3 ES 91121624 T ES91121624 T ES 91121624T ES 91121624 T ES91121624 T ES 91121624T ES 2130130 T3 ES2130130 T3 ES 2130130T3
Authority
ES
Spain
Prior art keywords
amino acid
short peptides
covalent bond
insulin effect
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121624T
Other languages
English (en)
Inventor
Stefan Dr Mullner
Wolfgang Dr Konig
Gunter Dr Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2130130T3 publication Critical patent/ES2130130T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN PEPTIDOS CORTOS DE LA FORMULA I DONDE A Y B REPRESENTAN UN ACIDO DE AMINO O UN ENLACE COVALENTE, C Y D REPRESENTAN UN ACIDO DE AMINO O UN ACIDO DE AMINO SUSTITUIDO, E REPRESENTA UN ACIDO DE AMINO MODIFICADO O NO MODIFICADO O UN ENLACE COVALENTE, X REPRESENTA UN RESTO O UN HIDROGENO E Y REPRESENTA LEUCINA O UN ENLACE COVALENTE O DIMEROS DE LOS PEPTIDOS DE LA FORMULA I CON CISTINA COMO COMPONENTES DE LA DIMERISIFICACION. TAMBIEN SE DESCRIBEN SUS FORMAS ESTEREOISOMERAS O SUS SALES, QUE SON TOLERANTES PSICOLOGICAMENTE, SU ELABORACION, ASI COMO SU EMPLEO PARA EL TRATAMIENTO DE LA DIABETES MELLITUS.
ES91121624T 1990-12-19 1991-12-17 Peptidos cortos con efecto de insulina. Expired - Lifetime ES2130130T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4040574 1990-12-19

Publications (1)

Publication Number Publication Date
ES2130130T3 true ES2130130T3 (es) 1999-07-01

Family

ID=6420676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121624T Expired - Lifetime ES2130130T3 (es) 1990-12-19 1991-12-17 Peptidos cortos con efecto de insulina.

Country Status (24)

Country Link
US (1) US5461035A (es)
EP (1) EP0491361B1 (es)
JP (2) JP3378588B2 (es)
KR (1) KR100237948B1 (es)
AT (1) ATE177753T1 (es)
AU (1) AU643349B2 (es)
CA (1) CA2058020C (es)
CZ (1) CZ284568B6 (es)
DE (1) DE59109109D1 (es)
DK (1) DK0491361T3 (es)
ES (1) ES2130130T3 (es)
FI (1) FI105816B (es)
GR (1) GR3030510T3 (es)
HR (1) HRP940839B1 (es)
HU (1) HU222493B1 (es)
IE (1) IE914408A1 (es)
IL (1) IL100400A (es)
NO (1) NO308951B1 (es)
NZ (1) NZ241029A (es)
PT (1) PT99850B (es)
SK (2) SK282360B6 (es)
TW (1) TW227004B (es)
YU (1) YU189891A (es)
ZA (1) ZA919938B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0545198B1 (de) * 1991-11-29 1999-09-15 Hoechst Aktiengesellschaft Peptide mit insulinartiger Wirkung
SE0002716L (sv) * 2000-07-18 2002-01-19 Lars Wahlberg Komposition mot insekter
CN100354118C (zh) * 2001-01-15 2007-12-12 米其林技术公司 轮胎成型鼓
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
KR101909052B1 (ko) 2017-02-09 2018-10-17 강원대학교산학협력단 인슐린의 a 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2740406A1 (de) * 1977-09-08 1979-03-22 Hoechst Ag Teilgeschuetzte human-insulin-a-kette und verfahren zu ihrer herstellung
DE2801175A1 (de) * 1978-01-12 1979-07-19 Hoechst Ag Verfahren zur herstellung cysteinhaltiger peptide
DD147942A1 (de) * 1979-08-20 1981-04-29 Guenter Losse Verfahren zur herstellung von cystin-peptiden mit insulinaehnlicher wirkung
FR2525592B1 (es) * 1982-04-26 1984-09-14 Pasteur Institut

Also Published As

Publication number Publication date
FI915933A0 (fi) 1991-12-17
FI915933A (fi) 1992-06-20
NO308951B1 (no) 2000-11-20
US5461035A (en) 1995-10-24
AU8982591A (en) 1992-06-25
SK282361B6 (sk) 2002-01-07
JP3802863B2 (ja) 2006-07-26
HRP940839A2 (en) 1997-06-30
FI105816B (fi) 2000-10-13
ZA919938B (en) 1992-09-30
HU914009D0 (en) 1992-03-30
TW227004B (es) 1994-07-21
PT99850A (pt) 1992-11-30
HUT59697A (en) 1992-06-29
PT99850B (pt) 1999-06-30
YU189891A (sh) 1995-10-03
NO914999L (no) 1992-06-22
KR920012115A (ko) 1992-07-25
AU643349B2 (en) 1993-11-11
GR3030510T3 (en) 1999-10-29
CS387991A3 (en) 1992-07-15
CA2058020C (en) 2003-10-28
EP0491361A2 (de) 1992-06-24
NO914999D0 (no) 1991-12-18
DK0491361T3 (da) 1999-10-11
HRP940839B1 (en) 2000-02-29
KR100237948B1 (ko) 2000-01-15
IL100400A (en) 1998-01-04
SK282360B6 (sk) 2002-01-07
DE59109109D1 (de) 1999-04-22
EP0491361A3 (en) 1993-11-24
IE914408A1 (en) 1992-07-01
EP0491361B1 (de) 1999-03-17
JPH04295496A (ja) 1992-10-20
IL100400A0 (en) 1992-09-06
JP2003176237A (ja) 2003-06-24
NZ241029A (en) 1993-01-27
JP3378588B2 (ja) 2003-02-17
CA2058020A1 (en) 1992-06-20
CZ284568B6 (cs) 1999-01-13
HU222493B1 (hu) 2003-07-28
ATE177753T1 (de) 1999-04-15

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