NO305794B1 - Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler - Google Patents

Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Info

Publication number
NO305794B1
NO305794B1 NO953352A NO953352A NO305794B1 NO 305794 B1 NO305794 B1 NO 305794B1 NO 953352 A NO953352 A NO 953352A NO 953352 A NO953352 A NO 953352A NO 305794 B1 NO305794 B1 NO 305794B1
Authority
NO
Norway
Prior art keywords
benzoic acid
ortho
pharmaceuticals
compounds
manufacture
Prior art date
Application number
NO953352A
Other languages
English (en)
Other versions
NO953352L (no
NO953352D0 (no
Inventor
Rolf Gericke
Dieter Dorsch
Manfred Baumgarth
Klaus-Otto Minck
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO953352D0 publication Critical patent/NO953352D0/no
Publication of NO953352L publication Critical patent/NO953352L/no
Publication of NO305794B1 publication Critical patent/NO305794B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO953352A 1994-08-28 1995-08-25 Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler NO305794B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430212A DE4430212A1 (de) 1994-08-28 1994-08-28 Ortho-substituierte Benzoesäure-Derivate

Publications (3)

Publication Number Publication Date
NO953352D0 NO953352D0 (no) 1995-08-25
NO953352L NO953352L (no) 1996-02-29
NO305794B1 true NO305794B1 (no) 1999-07-26

Family

ID=6526569

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953352A NO305794B1 (no) 1994-08-28 1995-08-25 Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler

Country Status (23)

Country Link
US (1) US5849796A (no)
EP (1) EP0704431B1 (no)
JP (1) JPH0859602A (no)
KR (1) KR100406686B1 (no)
CN (1) CN1068587C (no)
AT (1) ATE193282T1 (no)
AU (1) AU703633B2 (no)
BR (1) BR9503817A (no)
CA (1) CA2156959A1 (no)
CZ (1) CZ289492B6 (no)
DE (2) DE4430212A1 (no)
DK (1) DK0704431T3 (no)
ES (1) ES2147810T3 (no)
GR (1) GR3033989T3 (no)
HU (1) HUT74946A (no)
NO (1) NO305794B1 (no)
PL (1) PL181183B1 (no)
PT (1) PT704431E (no)
RU (1) RU2125981C1 (no)
SK (1) SK282202B6 (no)
TW (1) TW406067B (no)
UA (1) UA44238C2 (no)
ZA (1) ZA957161B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19919349A1 (de) * 1999-04-28 2000-11-02 Merck Patent Gmbh Verfahren zur Herstellung eines Benzoylguanidinderivates
ES2276829T3 (es) * 2000-09-21 2007-07-01 Novation Pharmaceuticals Inc. Derivados de acido benzoico y su utilizacion.
IL160253A0 (en) * 2001-08-09 2004-07-25 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
ES2436467T3 (es) * 2002-03-20 2014-01-02 University Of Maryland Baltimore Un canal catiónico no selectivo en células neurales y antagonistas de Sur1 para el tratamiento de la inflamación del cerebro
ATE487484T1 (de) 2004-09-18 2010-11-15 Univ Maryland Therapeutische mittel zum targeting des nc ca-atp-kanals und verwendungsverfahren dafür
AU2005290238A1 (en) * 2004-09-18 2006-04-06 Department Of Veterans Affairs Therapeutic agents trageting the NCCa-ATP channel and methods of use thereof
EP1893612B1 (en) * 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
CA2674949A1 (en) 2007-01-12 2008-07-24 J. Marc Simard Targeting ncca-atp channel for organ protection following ischemic episode
US20100092469A1 (en) * 2007-02-09 2010-04-15 Simard J Marc Antagonists of a non-selective cation channel in neural cells
CA2691199C (en) 2007-06-22 2017-09-12 Marc J. Simard Inhibitors of ncca-atp channels for therapy
LT6401B (lt) * 2015-07-28 2017-06-12 Vilniaus Universitetas Karboanhidrazės selektyvūs inhibitoriai
CN105732357A (zh) * 2016-03-23 2016-07-06 叶芳 2-氯-4氟苯甲酸及其制备方法
CN106892852B (zh) * 2017-03-21 2019-07-09 重庆医科大学 具有抗流感病毒活性的胍基类似物及其制备方法
CN111116395B (zh) * 2019-12-27 2023-04-07 湖北工业大学 多碘代芳香酸类化合物及其在抗腺病毒7型中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556673B1 (de) * 1992-02-15 1997-09-17 Hoechst Aktiengesellschaft Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE139526T1 (de) * 1992-02-15 1996-07-15 Hoechst Ag 3,5-substituierte benzoylguanidine, mit antiarrythmischer wirkung und inhibierender wirkung auf die proliferationen von zellen
DE59304166D1 (de) * 1992-07-01 1996-11-21 Hoechst Ag 3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
TW250479B (no) * 1992-12-15 1995-07-01 Hoechst Ag
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
EP0704431A2 (de) 1996-04-03
EP0704431A3 (de) 1997-01-29
DK0704431T3 (da) 2000-09-11
PL310192A1 (en) 1996-03-04
CZ289492B6 (cs) 2002-02-13
AU3014595A (en) 1996-03-14
SK282202B6 (sk) 2001-12-03
ATE193282T1 (de) 2000-06-15
GR3033989T3 (en) 2000-11-30
HUT74946A (en) 1997-03-28
ES2147810T3 (es) 2000-10-01
DE4430212A1 (de) 1996-02-29
TW406067B (en) 2000-09-21
ZA957161B (en) 1996-04-17
JPH0859602A (ja) 1996-03-05
EP0704431B1 (de) 2000-05-24
KR960007539A (ko) 1996-03-22
HU9502500D0 (en) 1995-10-30
CA2156959A1 (en) 1996-03-01
NO953352L (no) 1996-02-29
SK105495A3 (en) 1996-03-06
PT704431E (pt) 2000-10-31
US5849796A (en) 1998-12-15
RU2125981C1 (ru) 1999-02-10
CN1068587C (zh) 2001-07-18
KR100406686B1 (ko) 2004-07-19
NO953352D0 (no) 1995-08-25
CZ218195A3 (en) 1996-03-13
AU703633B2 (en) 1999-03-25
PL181183B1 (pl) 2001-06-29
CN1125722A (zh) 1996-07-03
UA44238C2 (uk) 2002-02-15
BR9503817A (pt) 1996-04-16
DE59508383D1 (de) 2000-06-29

Similar Documents

Publication Publication Date Title
NO305794B1 (no) Ortosubstituerte benzosyrederivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305798B1 (no) Heterosyklylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
FI955024A0 (fi) Uudet piperidiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
NO305246B1 (no) Oksazolidinonforbindelser, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, og anvendelse av forbindelsene til fremstilling av legemidler
NO305242B1 (no) Arylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
DK0404283T3 (da) 11alfa-aryl-4-estrener, fremgangsmåde til fremstilling af disse samt deres anvendelse som lægemidler
NO304988B1 (no) 11-benzaldoksim-17<beta>-metoksy-17<alfa>-metoksymetyl-°stradienderivater samt farmas°ytisk preparat inneholdende slike
ZA889559B (en) Substituted 6-phenyldihydro-3(2h)-pyridazinones,a process for their preparation and pharmaceutical preparations containing these compounds
TR199903120T2 (xx) Yeni sistein türevleri, bunların üretimi için işlemler ve bunları ihtiva eden farmasötik maddeler.
NO306858B1 (no) Sulfonyl- eller sulfinylbenzoylguanidinderivater, farmasöytiske preparater som inneholder slike, samt anvendelse av dem til fremstilling av legemidler
NO305206B1 (no) Oksazolidinonkarboksylsyrederivater, farmas°ytiske preparater som inneholder slike forbindelser, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305901B1 (no) Alkylbenzoylguanidiner, farmasöytiske preparater som inneholder minst en slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
DK162646C (da) 3-(4-benzyl-piperazin-1-yl)-rifamycin sv- og s-forbindelser samt salte deraf, fremgangsmaade til fremstilling deraf og farmaceutiske sammensaetninger indeholdende disse forbindelser
DE3486191T2 (de) Arzneimittel mit systematischer anticholinesterasischer, agonistisch-cholinergischer und antimuskariner Wirkung.
NO306157B1 (no) Fluorholdige benzoylguanidiner, farmasöytiske preparater som inneholder minst én slik forbindelse, samt anvendelse av forbindelsene til fremstilling av et legemiddel
NO305243B1 (no) Benzoylguanidinderivater, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av et legemiddel
NO306991B1 (no) Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
NO305597B1 (no) Heterosyklyloksybenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
FR2694005B1 (fr) Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
NO306300B1 (no) 3-alkoksykarbonyltiadiazinoner, farmasöytiske preparater som inneholder minst èn slik forbindelse, og anvendelse av forbindelsene til fremstilling av legemidler
BR9810893A (pt) Medicamentos, composto derivado de poli-hidroxialquilpirazina, processo para preparação dos compostos, e, uso de um composto.
TH9330EX (th) คลอโรซับสทิทิวเทดเบนซิมิดาโซลที่ออกฤทธิ์ในทางรักษาโรค

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees